Europium-functionalized luminescent titania nanotube arrays: Utilizing interactions with glucose, cholesterol and triglycerides for rapid detection application

Su, Baoze; Yang, Wenbin; Wang, Yao; Huang, Linjun; Popat, Ketul C.; Kipper, Matt J.; Belfiore, Laurence A.; Tang, Jianguo

doi:10.1016/j.msec.2020.111054

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…However, due to the prohibition of the 4f-4f transition, the absorption and emission intensity of the rare earth ion itself is very weak [ 33 ]. When lanthanide ions are coordinated with small molecular organic ligands (such as 2-thienyl trifluoroacetone (TTA), acetylacetone (acac), and 1,10-phenanthroline (phen)), the fluorescent properties of lanthanide complexes can be significantly improved through the antenna effect [ 34 , 35 , 36 ]. Therefore, if the local environment of the coordination complex changes, such as via ligand exchange, these changes can be sensitively detected by the resulting change in fluorescence intensity.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

Guo

Liu

Tang

et al. 2022

IJMS

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The clinical use of anticancer drugs necessitates new technologies for their safe, sensitive, and selective detection. In this article, lanthanide (Eu3+ and Tb3+)-loaded γ-cyclodextrin nano-aggregates (ECA and TCA) are reported, which sensitively detects the anticancer drug irinotecan by fluorescence intensity changes. Fluorescent lanthanide (Eu3+ and Tb3+) complexes exhibit high fluorescence intensity, narrow and distinct emission bands, long fluorescence lifetime, and insensitivity to photobleaching. However, these lanthanide (Eu3+ and Tb3+) complexes are essentially hydrophobic, toxic, and non-biocompatible. Lanthanide (Eu3+ and Tb3+) complexes were loaded into naturally hydrophilic γ-cyclodextrin to form fluorescent nano-aggregates. The biological nontoxicity and cytocompatibility of ECA and TCA fluorescent nanoparticles were demonstrated by cytotoxicity experiments. The ECA and TCA fluorescence nanosensors can detect irinotecan selectively and sensitively through the change of fluorescence intensity, with detection limits of 6.80 μM and 2.89 μM, respectively. ECA can safely detect irinotecan in the cellular environment, while TCA can detect irinotecan intracellularly and is suitable for cell labeling.

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Section: Introductionmentioning

confidence: 99%

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

Guo

Liu

Tang

et al. 2022

IJMS

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“…The synthesis of several vitamins, steroid hormones, and bile acids also needs cholesterol. However, excessive levels of cholesterol are one of the culprits affecting human health . Due to the increasing incidence of people with coronary heart diseases, myocardial infarction, and stroke, people have started paying increasing attention to the negative impact of cholesterol. , Thus, the level of cholesterol is an imperative indicator in assessing a person’s level of health.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin-Modified NiS₂ Nanoparticles Anchored on Graphene for the Specific Determination of Cholesterol

Zhu

Xue

et al. 2021

ACS Appl. Nano Mater.

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Exploring peroxidase-like nanozymes with high catalytic activity is an urgent task to construct a fast, convenient, and selective colorimetric sensing platform. In this work, a nanozyme, 5,10,15,20-tetrakis(4-carboxyl phenyl)porphyrin-functionalized NiS 2 nanoparticles, anchored on the surface of graphene (Por-NiS 2 /GO) was designed. Compared with NiS 2 nanoparticles anchored on the surface of graphene (NiS 2 /GO), Por-NiS 2 /GO had a higher peroxidase-like activity due to the introduction of porphyrin. The size of NiS 2 nanoparticles was about 110−250 nm. The peroxidase-like behaviors of Por-NiS 2 /GO were evaluated using the chromogenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB) with a fast-blue color change in less than 1 min. Electron spin resonance (ESR) data revealed that the excellent performance of Por-NiS 2 / GO was due to the active oxygen species produced, including hydroxyl radical ( • OH) and superoxide radical ( • O 2 − ), during the catalytic reaction, owing to the synergetic effect among different components including porphyrin, NiS 2 , and GO. Thus, based on the enhanced peroxidase-like activity of Por-NiS 2 /GO, a fast, sensitive, and selective colorimetric sensing platform of H 2 O 2 has been constructed, and furthermore, a sensing platform for cholesterol was also developed coupled with cholesterol oxidase (ChOx). The colorimetric sensing platform was validated by detecting cholesterol in serum samples.

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Advances in Microfluidic Paper‐Based Analytical Devices (µPADs): Design, Fabrication, and Applications

Chen,

Njoku,

Tang

et al. 2024

Small Methods

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Microfluidic Paper‐based Analytical Devices (µPADs) have emerged as a new class of microfluidic systems, offering numerous advantages over traditional microfluidic chips. These advantages include simplicity, cost‐effectiveness, stability, storability, disposability, and portability. As a result, various designs for different types of assays are developed and investigated. In recent years, µPADs are combined with conventional detection methods to enable rapid on‐site detection, providing results comparable to expensive and sophisticated large‐scale testing methods that require more time and skilled personnel. The application of µPAD techniques is extensive in environmental quality control/analysis, clinical diagnosis, and food safety testing, paving the way for on‐site real‐time diagnosis as a promising future development. This review focuses on the recent research advancements in the design, fabrication, material selection, and detection methods of µPADs. It provides a comprehensive understanding of their principles of operation, applications, and future development prospects.

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Europium-functionalized luminescent titania nanotube arrays: Utilizing interactions with glucose, cholesterol and triglycerides for rapid detection application

Cited by 6 publications

References 45 publications

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

Porphyrin-Modified NiS₂ Nanoparticles Anchored on Graphene for the Specific Determination of Cholesterol

Advances in Microfluidic Paper‐Based Analytical Devices (µPADs): Design, Fabrication, and Applications

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Europium-functionalized luminescent titania nanotube arrays: Utilizing interactions with glucose, cholesterol and triglycerides for rapid detection application

Cited by 6 publications

References 45 publications

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

Porphyrin-Modified NiS2 Nanoparticles Anchored on Graphene for the Specific Determination of Cholesterol

Advances in Microfluidic Paper‐Based Analytical Devices (µPADs): Design, Fabrication, and Applications

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Porphyrin-Modified NiS₂ Nanoparticles Anchored on Graphene for the Specific Determination of Cholesterol