EUS-guided sampling of suspected GI stromal tumors

Hoda, Katherine M.; Rodriguez, Sarah A.; Faigel, Douglas O.

doi:10.1016/j.gie.2008.09.045

Cited by 206 publications

(187 citation statements)

References 21 publications

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“…Interestingly, there was no significant difference in diagnostic yield for the different needle sizes or the number of passes. There have been similar findings in other studies [14,16].…”

supporting

confidence: 92%

“…Higher yields have been reported by other authors but these have included ''suspicious'' cytology findings without confirmatory IHC staining [14,15]. The current study also reports a yield of 80% when both definite and suspicious diagnosis is considered.…”

supporting

confidence: 49%

“…These findings make sense conceptually, but they have not been replicated consistently in other studies. For instance, the anatomic location of GISTs has not been demonstrated to improve diagnostic yield [14,16], whereas improved yield with increasing size of the lesion has been suggested [15,16]. However, it has also been reported that the yield may actually decrease, presumably because of necrosis, if the lesion size is [10 cm [15].…”

mentioning

confidence: 99%

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EUS-Guided Fine Needle Aspiration of Gastrointestinal Stromal Tumors: The GIST of the Matter

Chandrasekhara

Ahmad

2011

Dig Dis Sci

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“…Interestingly, there was no significant difference in diagnostic yield for the different needle sizes or the number of passes. There have been similar findings in other studies [14,16].…”

supporting

confidence: 92%

supporting

confidence: 49%

mentioning

confidence: 99%

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EUS-Guided Fine Needle Aspiration of Gastrointestinal Stromal Tumors: The GIST of the Matter

Chandrasekhara

Ahmad

2011

Dig Dis Sci

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“…The definitive cytological and/or histological verification of larger gastric GIST is currently achieved in 50%-70% of EUS-guided fineneedle aspiration (FNA) or EUS-guided Trucut punch biopsies [10][11][12][13][14][15] . The histological diagnosis of GIST requires immunohistochemical detection of CD117 and particularly in CD117-negative tumors of DOG1 with the corresponding histomorphological findings.…”

Section: Eus and Eus-fnamentioning

confidence: 99%

Management of early asymptomatic gastrointestinal stromal tumors of the stomach

Scherübl

Faiss

Knoefel

et al. 2014

WJGE

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Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract. Approximately two thirds of clinically manifest tumors occur in the stomach, nearly one third in the small bowel, and the rest in the colorectal region with a few cases in the esophagus. GIST originate within the smooth muscle layer in the wall of the tubular gastrointestinal tract and grow mostly toward the serosa, far less often toward the mucosa. In the latter case, ulceration may develop and can cause gastrointestinal bleeding as the cardinal symptom. However, most GIST of the stomach are asymptomatic. They are increasingly detected incidentally as small intramural or submucosal tumors during endoscopy and particularly during endoscopic ultrasound. Epidemiological and molecular genetic findings suggest that early asymptomatic GIST of the stomach (< 1 cm) show self-limiting tumorigenesis. Thus, early (< 1 cm) asymptomatic gastric GIST (synonym: micro-GIST) are found in 20%-30% of the elderly. The mostly elderly people with early gastric GIST have an excellent GIST-specific prognosis. Patients with early GIST of the stomach can therefore be managed by endoscopic surveillance.

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“…Gastrointestinal stromal tumors (GISTs) account for approximately 2% of gastric cancers [1] and can be challenging to diagnose due to the difficulty sampling tissue from these lesions [2]. There is no consensus on the management of these lesions, particularly when they are small or asymptomatic [3].…”

Section: Introductionmentioning

confidence: 99%

<i>Ex vivo</i> evaluation of a prototype submucosal biopsy forceps for the diagnosis of gastric gastrointestinal stromal tumors

Laczek¹,

Hanna²,

Twaddell³

et al. 2012

OJGas

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Gastrointestinal stromal tumors (GISTs) account for approximately 2% of gastric cancers and can be challenging to diagnose due to the difficulty sampling tissue from these lesions. Current biopsy methods are inadequate for determining the mitotic index, a major prognostic factor of these tumors. We sought to evaluate the ability of a prototype submucosal biopsy forceps to make a histologic diagnosis and mitotic index determination in cases of resected gastric GISTs. After obtaining informed consent and surgical resection of three gastric GISTs, an investigational submucosal biopsy forceps and sheath was passed under direct visualization into the central portion of the tumors (in the ex vivo setting) and biopsies were obtained. The tumor was then processed for standard histology. A gastrointestinal pathologist, blinded to the mitotic index of the full specimen, evaluated the research biopsies. The results from the submucosal forceps biopsies were then compared with the standard histology results. In all 3 cases, the submucosal forceps biopsies confirmed the diagnosis of a GIST. In two out of three cases, the submucosal forceps biopsies accurately classified the risk for progressive disease (based on the mitotic index) when compared to standard histology. In one case, the research biopsy mitotic index would have resulted in an underestimation of tumor risk (biopsies categorized the lesion as "very low" rather than "moderate" risk).

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EUS-guided sampling of suspected GI stromal tumors

Cited by 206 publications

References 21 publications

EUS-Guided Fine Needle Aspiration of Gastrointestinal Stromal Tumors: The GIST of the Matter

EUS-Guided Fine Needle Aspiration of Gastrointestinal Stromal Tumors: The GIST of the Matter

Management of early asymptomatic gastrointestinal stromal tumors of the stomach

<i>Ex vivo</i> evaluation of a prototype submucosal biopsy forceps for the diagnosis of gastric gastrointestinal stromal tumors

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EUS-guided sampling of suspected GI stromal tumors

Cited by 206 publications

References 21 publications

EUS-Guided Fine Needle Aspiration of Gastrointestinal Stromal Tumors: The GIST of the Matter

EUS-Guided Fine Needle Aspiration of Gastrointestinal Stromal Tumors: The GIST of the Matter

Management of early asymptomatic gastrointestinal stromal tumors of the stomach

&lt;i&gt;Ex vivo&lt;/i&gt; evaluation of a prototype submucosal biopsy forceps for the diagnosis of gastric gastrointestinal stromal tumors

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<i>Ex vivo</i> evaluation of a prototype submucosal biopsy forceps for the diagnosis of gastric gastrointestinal stromal tumors