“…They suggested that several factors, such as physical, psychological, and existential distress, including pain, impairment of physical functioning, depression, loss of independence, and loss of autonomy, account for the suicides among cancer patients. 9,10 In addition, several studies have demonstrated that the prevalence of the desire for death among terminally ill cancer patients is not rare (range, 8.5-17.4%) [11][12][13][14] and that pain, weakness, loss of control, depression, hopelessness, and social support factors are associated significantly with the desire for death. [11][12][13][14][15][16][17] However, the samples in these studies were heterogeneous and the study designs were cross-sectional, calling causality into question.…”