Evalation of Relationship Between Markers of Liver Function and the Onset of Type 2 Diabetes

Abstract

Background and Objective: Type 2 diabetic individuals are highly prone to liver function test abnormalities than non-diabetic individuals. Increased activities of liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and ?- glutamyl transpeptidase (GGT) are indicators of hepatocellular injury. Increased activity of these markers is associated with insulin resistance [1], metabolic syndrome, and type 2 diabetes. Diabetes mellitus burden is one of the key concerns in developing countries like India. In this study, we evaluated the relationships between markers of liver function and the onset of type 2 diabetes. Materials and Methods: This study was conducted after the approval from institutional ethical committee. Twenty five patients reporting to the OPD of K. S. Hegde Hospital diagnosed for type 2 diabetes between the age group of 40-50 years of both sex and 25 healthy age and sex matched individuals were included in the study. Under aseptic precautions blood samples were collected and centrifuged to get serum and was used for estimation. Data were expressed as the mean ± SD. Spearman's correlation coefficients were calculated to evaluate the relationship between serum glucose and liver function enzymes. Result: The results of the present showed that the ALT, AST and GGT levels in Type 2 Diabetic patients was increased significantly (p<0.01) as compared to normal controls. Conclusion: In this study, we found an association between the level of liver enzymes, ALT, AST and GGT in type 2 diabetes. Thus these liver enzyme levels can be used as a biomarker for the assessment of type 2 diabetes.

Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross‐sectional study in Bangladeshi adults

“…The gender difference in elevated liver enzymes may be a reason for the individual's differences in body fat distribution and metabolism. The elevated levels of liver enzymes have been reported in Indian, Thai, Algerian and Chinese population. A wide variation has been observed on the prevalence of increased hepatic enzymes in these studies.…”

“…The presence of liver disease in T2D patients has received increased attention because of their long‐term health consequences and economic burden for National Health Services . Individuals with T2D are highly prone to liver function test abnormalities than nondiabetic healthy individuals . In epidemiological studies, T2D has found to be related to different liver diseases including nonalcoholic fatty liver disease (NAFLD), liver cirrhosis and hepatocellular carcinoma .…”

“…Previously, some studies have been conducted to assess the relationship between liver enzymes and T2D in Asian, European and American populations . Most of the previous study examined the associations that included only two or three liver enzymes, and there are a limited number of studies that examined maximum number (four) of liver enzymes to evaluate the relationship with T2D.…”

Type Ii Diabetes Mellitus;

“…Thus it was concluded that these enzymes can be used as a biomarker for evaluation of type 2 diabetes. 11 Belay Z et al performed a similar study and found that not only ALT and AST but ALP, total bilirubin, direct bilirubin and serum glucose were significantly higher in incidence among patients of type 2 diabetes mellitus. 12 Statins as a drug are quite useful in medical field and there is no way they can be stopped from being used.…”

ETL for disease indicators using brute force rule-based NLP algorithm and metadata exploration

“…An improved treatment can be assured if this disease is predicted at an early stage. Unbalanced liver enzymes in diabetic people act as the hepatocellular damage indicators [14]. Diabetes lowers "good" cholesterol levels and raises triglyceride levels [15].…”