Evaluación de la enfermedad renal litiásica. Estudio metabólico

Trapote, R. Areses; Garagorri, M.A. Urbieta; Arrieta, M. Ubetagoyena; Monge, Taira; Lizarraga, D. Arruebarrena

doi:10.1016/s1695-4033(04)78417-9

Cited by 14 publications

(4 citation statements)

References 18 publications

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“…Thus, this population must be closely followed and, even after this first episode, be evaluated with a complete metabolic study because the rule is recurrence [8,9]. Some authors defend that metabolic study and analysis of stone are important for determining different profiles of lithogenic risk, which allows for adequate treatment to be based on risk [10]. In this sense, there are several articles about metabolic alterations in patients with nephrolithiasis and assessment of these according to age and sex.…”

Section: Discussionmentioning

confidence: 99%

Bone and Metabolic Markers in Women With Recurrent Calcium Stones

2013

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PurposeThe target of our work was to study several biochemical parameters in phospho-calcic and bone metabolism in blood and urine and the bone mineral density of women with recurrent calcium nephrolithiasis.Materials and MethodsWe conducted a cross-sectional study with a control group of 85 women divided into 3 groups: group 1 consisted of 25 women without a history of nephrolithiasis, group 2 consisted of 35 women with only one episode of calcium nephrolithiasis, and group 3 consisted of 25 women with a history of recurrent calcium nephrolithiasis. Blood and urine biochemical study was performed, including markers related to lithiasis, and a bone mineral density study was done by use of bone densitometry.ResultsPatients in group 3 showed statistically significantly elevated calciuria (15.4 mg/dL), fasting calcium/creatinine ratio (0.14), and 24-hour calcium/creatinine ratio (0.21) compared with groups 1 and 2. Moreover, this group of women with recurrent calcium nephrolithiasis had significantly elevated values of beta-crosslaps, a bone resorption marker, compared with groups 1 and 2 (p=0.000) and showed more bone mineral density loss than did these groups.ConclusionsRecurrent calcium nephrolithiasis in women has a significant association with bone mineral density loss and with values of calciuria, both fasting and 24-hour.

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Section: Discussionmentioning

confidence: 99%

Bone and Metabolic Markers in Women With Recurrent Calcium Stones

2013

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“…However, recent trends show metabolic factors now play a dominant role in pediatric urolithiasis cases [11][12][13]. Indeed, metabolic issues are implicated in the majority of pediatric cases with stone disease [7,8,[12][13][14].…”

Section: Risk Factors Of Pediatric Stone Diseasementioning

confidence: 99%

Current Status and Prospects of Pediatric Stone Disease: A Bibliometric and Visualization Study

Chen,

Zhang,

Zhang

et al. 2024

Cureus

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Pediatric stone disease, once considered rare, has emerged as a significant research area in the past two decades due to a sharp increase in its incidence. Understanding the evolving epidemiology and treatment strategies for pediatric stone disease is crucial for enhancing child health protection. This study aims to summarize the advancements in pediatric stone disease research over the last two decades through bibliometric analysis. We conducted a comprehensive search in the Web of Science Core Collection (WoSCC) for literature on pediatric stone disease from January 1, 2000 to February 20, 2024. Econometric analyses were performed using tools such as VOSviewer, CiteSpace, and the R package "bibliometrix." Our search yielded 1,208 publications, predominantly from the United States and Turkey, showing an annual increase in publications on pediatric stone disease. Leading research institutions include Dicle University, Children's Hospital of Philadelphia, and the University of Pennsylvania, with the Journal of Pediatric Urology publishing the highest number of articles. The most prolific authors were C.P. Nelson and B. Hoppe, with Caleb P. Nelson being the most co-cited author. Research themes primarily focused on risk factors and therapeutic approaches for pediatric stone disease. Emerging research hotspots are identified by keywords such as mechanism, mini-percutaneous nephrolithotomy, recurrence, and retrograde intrarenal surgery. The study forecasts a continued upward trend in global research on pediatric stone disease, with future studies likely to delve deeper into risk factors and novel therapeutic methods.

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“…On the other hand, chemical analysis of calculi is an inexact method that has now become obsolete. 16 …”

Section: Clinical and Metabolic Diagnosismentioning

confidence: 99%

“…A fasting urine test to assess the levels of calcium, creatinine, oxalate and citrate is also recommendable. 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 The analysis should be extended in order to determine the levels of bone resorption markers in cases of nephrocalcinosis, suspected hyperparathyroidism, fasting hypercalciuria or previous treatment for loss of bone mineral density. Blood tests should detect markers for intact parathyroid hormone (iPTH), vitamin D, alkaline phosphatase, osteocalcin and beta-crosslaps.…”

Section: Clinical and Metabolic Diagnosismentioning

confidence: 99%

Calcium renal lithiasis: metabolic diagnosis and medical treatment

2013

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Calcium renal lithiasis is a frequent condition that affects the worldwide population and has a high recurrence rate. Different metabolic changes may trigger the onset of calcium stone disorders, such as hypercalciuria, hyperoxaluria, hyperuricosuria, hypocitraturia and others. There are also other very prevalent disorders that are associated with calcium calculi, such as arterial hypertension, obesity and loss of bone mineral density. A correct diagnosis needs to be obtained through examining the serum and urinary parameters of mineral metabolism in order to carry out adequate prevention and treatment of this condition. Once the metabolic diagnosis is known, it is possible to establish dietary and pharmacological treatment that may enable monitoring of the disease and prevent recurrence of stone formation. Some advances in treating this pathological condition have been made, and these include use of sodium alendronate in patients with calcium renal lithiasis and osteopenia/osteoporosis, or use of a combination of a thiazide with a bisphosphonate. In summary, calcium renal lithiasis often requires multidrug treatment with strict control and follow-up of patients. RESUMOLitíase renal cálcica é uma doença comum que afeta a população no mundo todo e tem alta taxa de recorrência. Diferentes alterações metabólicas podem desencadear o aparecimento de distúrbios de pedras de cálcio, como hipercalciúria, hiperoxalúria, hiperuricosúria, hipocitratúria e outros. Existem também doenças altamente prevalentes associadas à doença de cálculo de cálcio, como hipertensão, obesidade e perda de densidade óssea mineral. Para realizar prevenção e tratamento adequados, é necessário diagnóstico correto, examinando o metabolismo mineral sérico e urinário. Depois de conhecer o diagnóstico metabólico, é possível estabelecer um tratamento dietético e farmacológico que permita controlar a doença e prevenir a recorrência de cálculos biliares. Há alguns avanços no tratamento dessa doença e incluem o uso de alendronato de sódio em pacientes com nefrolitíase de cálcio e osteopenia/osteoporose, ou a combinação de um tiazídico com um bifosfonato. Em resumo, litíase renal cálcica exige, muitas vezes, um tratamento multidroga com rigorosos controle e acompanhamento de pacientes.I MD. Resident in training, Urology Department,

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Evaluación de la enfermedad renal litiásica. Estudio metabólico

Cited by 14 publications

References 18 publications

Bone and Metabolic Markers in Women With Recurrent Calcium Stones

Bone and Metabolic Markers in Women With Recurrent Calcium Stones

Current Status and Prospects of Pediatric Stone Disease: A Bibliometric and Visualization Study

Calcium renal lithiasis: metabolic diagnosis and medical treatment

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