Evaluación de la globulina transportadora de hormonas esteroidales (SHBG) durante el embarazo como factor predictor de pre-eclampsia y restricción del crecimiento intrauterino

R, Enrique Valdés; A, Karina Lattes; S, Hernán Muñoz; Cumsille, Miguel A.

doi:10.4067/s0034-98872012000500005

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…These associations were more significant after the addition of MBzP to the model. The study by Valdés et al [69] and Xargay-Torrent et al [66] did not show any significant association between SHBG levels and gestational age of the neonate. The positive association between gestational age and FSH is a question to arouse interest because its concentration remains very low during pregnancy.…”

Section: Relationships Between Phthalate Metabolites Levels Maternal ...mentioning

confidence: 78%

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

et al. 2022

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Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This study aims to investigate if neonatal anthropometric parameters are associated with maternal endocrine parameters during the ≤15th week of gestation and the third trimester of pregnancy concerning phthalate exposure in pregnant women from Nitra, Slovakia. We used high-performance liquid chromatography, tandem mass spectrometry (HPLC-MS/MS), and electro-chemiluminescence immunoassay to quantify urinary concentrations of phthalates and serum concentrations of hormones and sex hormone-binding globulin (SHBG), respectively. We observed a mostly positive correlation between neonatal anthropometric parameters (gestational age, birth length, birth weight, head circumference) and maternal concentration of phthalate metabolites (p ≤ 0.05). The hierarchical multivariate regression results showed a statistically significant association between Apgar score at 5 min after delivery, gestational age, birth weight, head circumference, and maternal endocrine parameters during pregnancy (p ≤ 0.05), adjusted to phthalate metabolites. To the best of our knowledge, our study is the first to indicate that prenatal exposure to phthalates may also affect birth outcomes through interaction with the maternal endocrine system.

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Section: Relationships Between Phthalate Metabolites Levels Maternal ...mentioning

confidence: 78%

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

et al. 2022

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Impact of the Use of Metformin in the Prevention of Gestational Diabetes Mellitus in the High-Risk Population: An Article Review

Valdés Rubio

2024

Glucose and Insulin Homeostasis

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Gestational diabetes mellitus (GDM) is a condition characterized by a carbohydrate metabolism disorder of variable severity. The onset or first detection occurs during pregnancy. Its prevalence has increased dramatically in the last 10 years. Etiological factors that make these pregnant women a population at a high risk of developing GDM include maternal obesity, increase in maternal age, family history of diabetes mellitus, polycystic ovary (PCOS) and pregestational insulin resistance (PIR). The impact of metformin (MET), a second-generation insulin-sensitizing biguanide, on the prevention treatment of GDM has been studied with contradictory results. Through an article review of the literature, this chapter seeks to determine the safety and effectiveness of MET in preventing the development of GDM in patients with PIR in addition to evaluating the impact of oral hypoglycemic agents in the treatment of GDM and type 2 DM.

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Evaluación de la globulina transportadora de hormonas esteroidales (SHBG) durante el embarazo como factor predictor de pre-eclampsia y restricción del crecimiento intrauterino

Cited by 2 publications

References 25 publications

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

Impact of the Use of Metformin in the Prevention of Gestational Diabetes Mellitus in the High-Risk Population: An Article Review

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