Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina

Arancibia, Constanza; Galgani, José E.; Valderas, Juan P.; Morales, Michel; Santos, José Luís; Pollak, Felipe

doi:10.4067/s0034-98872014000900003

Cited by 20 publications

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“…Con respecto a la medición de insulinemia postsobrecarga oral a la glucosa, no lo recomendamos ya que el punto de corte usualmente utilizado (≥ 60 µUI/ml a las 2 h, en presencia de glicemia < 140 mg/dl), proviene de un estudio prospectivo realizado sólo en hombres cuyo objetivo era evaluar riesgo cardiovascular y no ha sido validado en nuestro medio 41 . En un estudio nacional, en que se analizaron 1.800 pruebas de tolerancia oral a la glucosa, realizadas en adultos de ambos sexos, este valor se encontraba en el percentil 55-60 42 . Además, como test presenta baja correlación con el clamp y alta variabilidad, lo que puede generar falsos positivos frecuentes 1 .…”

Section: ¿Cuáles Son Los Test De Laboratorio Para Medir La Ri?unclassified

II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina

et al. 2015

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Insulin resistance is a prevalent condition commonly associated with unhealthy lifestyles. It affects several metabolic pathways, increasing risk of abnormalities at different organ levels. Thus, diverse medical specialties should be involved in its diagnosis and treatment. With the purpose of unifying criteria about this condition, a scientific-based consensus was elaborated. A questionnaire including the most important topics such as cardio-metabolic risk, non-alcoholic fatty liver disease and polycystic ovary syndrome, was designed and sent to national experts. When no agreement among them was achieved, the Delphi methodology was applied. The main conclusions reached are that clinical findings are critical for the diagnosis of insulin resistance, not being necessary blood testing. Acquisition of a healthy lifestyle is the most important therapeutic tool. Insulin-sensitizing drugs should be prescribed to individuals at high risk of disease according to clinically validated outcomes. There are specific recommendations for pregnant women, children, adolescents and older people.

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Section: ¿Cuáles Son Los Test De Laboratorio Para Medir La Ri?unclassified

II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina

et al. 2015

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Development and assessment of the disposition index based on the oral glucose tolerance test in subjects with different glycaemic status

et al. 2015

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Insulin secretion and insulin sensitivity indexes are related by hyperbolic functions, allowing the calculation of the disposition index (DI) as the product of the acute insulin response (AIR) and the insulin sensitivity index (Si) from intravenous glucose tolerance test (IVGTT). Our objective was to develop an oral-DI based on the oral glucose tolerance test (OGTT) and to assess its association with glucose tolerance status. This research is structured in three studies. Study 1: OGTT were performed in 833 non-diabetic Chilean women (18-60 years) without family history of diabetes mellitus. Study 2: an independent group of n = 57 non-diabetic (18-46 years) without family history of diabetes mellitus carried out an OGTT and an abbreviated IVGTT. Study 3: a sample of 1674 Chilean adults (18-60 years) with different glycaemic status performed an OGTT. An adequate statistical fit for a rectangular hyperbola was found between the area under the curve of insulin-to-glucose ratio (AUCI/G-R) and the Matsuda ISI-COMP index (study 1). The oral-DI derived as AUCI/G-R × ISI-COMP was previously termed insulin-secretion-sensitivity index-2 (ISSI-2). ISSI-2 significantly correlated with DI from IVGTT (rho = 0.34; p = 0.009) (study 2). ISSI-2 shows important differences across groups of subjects with different glycaemic status (study 3). We have confirmed that ISSI-2 replicates the mathematical properties of DI, showing significant correlations with DI from the abbreviated MM-IVGTT. These results indicate that ISSI-2 constitutes a surrogate measure of insulin secretion relative to insulin sensitivity and emphasizes the pivotal role of impaired insulin secretion in the development of glucose homeostasis dysregulation.

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Pattern of C-peptide response to oral glucose tolerance test: Interest and cut-off values

Bonnet-Serrano¹,

Jaoude²,

Laguillier³

et al. 2022

Annales d'Endocrinologie

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Evaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina

Abstract: Evaluation of serum insulin levels after an oral glucose load for the diagnosis of insulin resistance p < 0, p < 0,001) (Rev Med Chile 2014; 142: 1106-1112

Cited by 20 publications

References 12 publications

II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina

II Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina

Development and assessment of the disposition index based on the oral glucose tolerance test in subjects with different glycaemic status

Pattern of C-peptide response to oral glucose tolerance test: Interest and cut-off values

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