Evaluación de la regresión en melanomas primarios sucesivos

Martín, J.M.; Pinazo, Isabel; Mateo, Joan; Escandell, I.; Jordá, Esperanza; Monteagudo, Carlos

doi:10.1016/j.ad.2014.01.006

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Spontaneous regression is frequently accompanied by tumour infiltration by CD8+ and also CD4+ T-cells [ 18 ] and vitiligo, a hypopigmented skin lesion, which may be associated with an antitumour response to melanocytes [ 19 ]. Interestingly, in patients with multiple asynchronous melanomas, the incidence of spontaneous regression was higher in successive melanomas compared to primary tumour, suggesting an increased anti-cancer immunity evoked by the primary lesion [ 20 ].…”

Section: Introduction To Melanoma and Cytokinesmentioning

confidence: 99%

Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research

Skalníková

Čížková

Cervenka

et al. 2017

IJMS

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Melanoma is a skin cancer with permanently increasing incidence and resistance to therapies in advanced stages. Reports of spontaneous regression and tumour infiltration with T-lymphocytes makes melanoma candidate for immunotherapies. Cytokines are key factors regulating immune response and intercellular communication in tumour microenvironment. Cytokines may be used in therapy of melanoma to modulate immune response. Cytokines also possess diagnostic and prognostic potential and cytokine production may reflect effects of immunotherapies. The purpose of this review is to give an overview of recent advances in proteomic techniques for the detection and quantification of cytokines in melanoma research. Approaches covered span from mass spectrometry to immunoassays for single molecule detection (ELISA, western blot), multiplex assays (chemiluminescent, bead-based (Luminex) and planar antibody arrays), ultrasensitive techniques (Singulex, Simoa, immuno-PCR, proximity ligation/extension assay, immunomagnetic reduction assay), to analyses of single cells producing cytokines (ELISpot, flow cytometry, mass cytometry and emerging techniques for single cell secretomics). Although this review is focused mainly on cancer and particularly melanoma, the discussed techniques are in general applicable to broad research field of biology and medicine, including stem cells, development, aging, immunology and intercellular communication.

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Section: Introduction To Melanoma and Cytokinesmentioning

confidence: 99%

Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research

Skalníková

Čížková

Cervenka

et al. 2017

IJMS

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“…According to some authors, patients who develop multiple asynchronous melanomas, namely the first melanoma, produce an immunisation effect with increased immunity against certain antigens expressed by tumour-associated melanocytes [ 25 ]. According to other authors, the presence of regression may be considered a favourable prognostic factor in patients with AJCC stage I-II melanoma.…”

Section: Discussionmentioning

confidence: 99%

Multiple Primary Cutaneous Melanomas in a Bulgarian Patient: The Possible Role of One Step Melanoma Surgery (OSMS) As the Most Adequate Treatment Approach!

Tchernev¹,

Temelkova²

2018

Open Access Maced J Med Sci

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BACKGROUND:Simultaneous occurrence of multiple primary melanomas is a rare, however possible phenomenon, and it is believed that older, male, white, Atypical Mole Syndrome carriers (sporadic and familial) are part of the possible risk factors for its occurrence. In these patients, it is possible to observe involutional changes or (partial/complete) regression of melanocytic lesions, which are likely to be caused by the generation of a spontaneous immune reaction against specific tumour antigens.CASE REPORT:A 58-year-old male patient is presented with two melanocytic lesions located in the right clavicle (subclavicular area) and left the scapular area that meets clinically and dermatoscopically the requirements for malignant melanoma. The lesions were removed by a radical excision with 0.5 cm surgical safety margin in all directions. During the subsequent histological verification it was established it was melanoma with a tumour thickness of 1 mm that in one case, and the other 2 mm. A week later, according to the recommendations of the current guidelines, a re-excision was performed with a surgical safety margin of 1.5 cm in all directions. Considering the complications that are possible during the parallel removal of a draining lymph node recommended for these tumour thicknesses, the patient definitively refused its detection and removal.CONCLUSION:A rare case of a Bulgarian patient with multiple primary, however partially involutional melanomas existing for over 20 years, is described. The individual recommendations of dermato-oncologists for the patient (according to AJCC) were not in favour of radicality but of a more sparing, individualised approach, appropriate for that patient. Unfortunately, the approach we used, in this case, was inconsistent with the AJCC or OSMS guidelines. The reason for individualising the approach in the case we have described is due to the variability of the recommendations for surgical treatment of melanomas laid down in the AJCC.

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“…Martín et al, 2014, reviewed 19 patients with MPM and found that the regression was significantly higher in successive melanomas than in the first tumour, suggesting an immunization effect from the first melanoma. Also, metastasis only occurred in patients without regression in their primary melanoma, suggesting a protective effect by regression [ 17 ].…”

Section: Multiple Primary Melanomasmentioning

confidence: 99%

Eleven Primary Melanomas, Colon Cancer, and Atypical Nevi in the Same Patient: A Case Report and Literature Review

Nielsen

Hölmich

2016

Case Reports in Dermatological Medicine

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Background. As the incidence of cutaneous malignant melanoma increases in the Caucasian population, an increasing population of melanoma survivors is at risk of developing multiple primary melanomas (MPM) as well as secondary primary cancers. Objective. To present a case of a patient with atypical nevi, 11 primary melanomas over 33 years, and colon cancer and to review the literature on multiple primary melanomas, atypical nevi, and correlation of nonmelanoma cancers. Conclusion. The literature indicates that patients with MPM are not uncommon, although 11 primary melanomas are rarely described, that patients with MPM may have a better survival than patients with single primary melanoma, that atypical nevi are a risk marker of not only melanoma in general but also MPM, and that melanoma patients have a significantly increased risk of developing nonmelanoma skin and other cancers, which may be even higher for patients with MPM.

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Evaluación de la regresión en melanomas primarios sucesivos

Cited by 7 publications

References 15 publications

Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research

Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research

Multiple Primary Cutaneous Melanomas in a Bulgarian Patient: The Possible Role of One Step Melanoma Surgery (OSMS) As the Most Adequate Treatment Approach!

Eleven Primary Melanomas, Colon Cancer, and Atypical Nevi in the Same Patient: A Case Report and Literature Review

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