Evaluación de la sensibilización a Der p 1 y Der p 2 en una población pediátrica del Norte de Portugal

Peixoto, Sara; Soares, Joana; Monteiro, Tânia; Carvalho, Marisa; Santos, Marinela; Simões, Carla; Quaresma, Márcia

doi:10.1016/j.anpedi.2017.10.014

Cited by 4 publications

(6 citation statements)

References 31 publications

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“…Our results show that the levels of IgEDerp2 is higher than IgEDerp1 3 , 6 , 7 , 19 , 20 without reaching statistical significance. However, since the sIgE production describes a non-linear curve and the commonly used method is an ELISA whose curve is not linear either, we can only say that there is a higher sIgE production for HDM group 2.…”

Section: Discussioncontrasting

confidence: 67%

“…While other studies showed a lower IgE responses to Der p 1 and Der p 2 for Australia (74–77%) and Singapore (63%) 18 . Our series shows the presence of the 4 phenotypes in production for IgEDerp1 and IgEDerp2 3 , 6 , 7 , 19 , 20 . The majority group DP (IgEDerp1 and IgEDerp2 double positives), significantly higher, followed by DN (double negative to IgEDerp1 and IgEDerp2) being the second most relevant group.…”

Section: Discussionmentioning

confidence: 67%

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Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion

Letrán¹,

García

Espinazo-Romeu

et al. 2021

Sci Rep

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Accessibility to more precise diagnostic techniques such as component resolved diagnostics (CRD), provides us with an important advance in diagnostic aspects as well as treatment. The subject of this study aims to better understand the profiles of sensitization to Der p 1, Der p 2 and Der p 23 and to know to what extent their use could help us in optimizing the decision-making for their treatment with Specific Immunotherapy. Cross-sectional study of subjects older than 5 years, diagnosed with allergy to HDM using skin prick test and sIgE, with symptoms of rhinitis and/or asthma. Total and specific IgE was determined to D. pteronyssinus, nDer p 1, rDer p 2 and rDer p 23 using ImmunoCAP. 240 patients were recruited (97.1% rhinitis and 46.25% rhinitis and asthma). Four different phenotypes were observed: positive or negative for sIgE nDer p 1 and/or IgE rDer p 2. 17% of these patients sIgE were double negative for Der p 1 and Der p 2 (increasing with age and with significantly lower sIgE levels than the rest of the groups). Using ROC curves, value less than 2.18 KUA/L for D. pteronyssinus sIgE gave us a sensitivity and specificity of 0.882 and 0.985, respectively, to double negative IgE nDer p 1 and IgE rDer p 2 group. Despite positive SPT and sIgE to D. pteronyssinus, 17% of the studied population is IgE nDer p 1 and IgE rDer p 2 double negative, with a cut-off value of 2.18 KU/L, which is very relevant for taking of decisions in prescription of AIT. The double positive population sIgE nDer p 1 and IgE rDer p 2 is associated with asthma compared to the other groups and this does not seem to be influenced by IgE rDer p 23.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 67%

Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion

Letrán¹,

García

Espinazo-Romeu

et al. 2021

Sci Rep

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“…Unless for immunotherapy clinical trials, this double negative group Derp1 and Derp2, should be excluded. Our results show that the levels of IgEDerp2 is higher than IgEDerp1 3,6,7,14,16 without reaching statistical significance. However, since the sIgE production describes a non-linear curve and the commonly used method is an ELISA whose curve is not linear either, we can only say that there is a higher sIgE production for HDM group 2.…”

Section: Discussioncontrasting

confidence: 64%

“…However, as a whole, for the diagnosis of sensitization to HDM, IgEDerp1 and IgEDerp2 are sufficient as the most relevant allergens and capable of diagnosing >95% of patients 3,13 . Our series shows the presence of the phenotypes in production for IgEDerp1 and IgEDerp2 3,6,7,14,16 . The majority group DP (IgEDerp1 and IgEDerp2 double positives), significantly higher, followed by DN (double negative to IgEDerp1 and IgEDerp2) being the second most relevant group.…”

Section: Discussionmentioning

confidence: 70%

“Cut-Off Value of Sige To D. Pteronyssinus in Double Negative Patients Der P 1 and Der P2 and Its Clinical Repercussion”.

Letrán¹,

García²,

Espinazo-Romeu³

et al. 2021

Preprint

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Background Accessibility to more precise diagnostic techniques such as component resolved diagnostics (CRD), provides us with an important advance in diagnostic aspects as well as treatment. Objective The subject of this study aims to better understand the profiles of sensitization to Der p 1, Der p 2 and Der p 23 and to know to what extent their use could help us in optimizing the decision-making for their treatment with Specific Immunotherapy. Method Cross-sectional study of subjects older than 5 years, diagnosed with allergy to HDM using skin prick test and sIgE, with symptoms of rhinitis and/or asthma. Total and specific IgE was determined to D. pteronyssinus, nDer p 1, rDer p 2 and rDer p 23 using ImmunoCAP. Results 240 patients were recruited (97.1% rhinitis and 46.25% rhinitis and asthma). Four different phenotypes were observed: positive or negative for sIgE nDer p 1 and/or IgE rDer p 2. 17% of these patients sIgE were double negative for Der p 1 and Der p 2 (increasing with age and with significantly lower sIgE levels than the rest of the groups). Using ROC curves, value less than 2.18 KU A /L for D. pteronyssinus sIgE gave us a sensitivity and specificity of 0.882 and 0.985, respectively, to double negative IgE nDer p 1 and IgE rDer p 2 group. Conclusions Despite positive SPT and sIgE to D. pteronyssinus, 17% of the studied population is IgE nDer p 1 and IgE rDer p 2 double negative, with a cut-off value of 2.18 KU/ L, which is very relevant for taking of decisions in prescription of AIT. The double positive population sIgE nDer p 1 and IgE rDer p 2 is associated with asthma compared to the other groups and this does not seem to be influenced by IgE rDer p 23.

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“…Of the currently known molecular components of HDMs, group 1 and 2 allergens (Der p 1, Der f 1, Der f 2 and Der f 2) as well as Der p 23 are considered to be the major sensitization elicitors on the American and the European continents [1,11]. However, scientists also include Dermatophagoides pteronyssinus Der p 5, Der p 7, Der p 21 allergens in the group of most clinically relevant ones [12,13].…”

Section: Introductionmentioning

confidence: 99%

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

et al. 2023

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Background As the process and nature of developing sensitivity to house dust mites (HDMs) remain not fully studied, our goal was to establish the pattern, nature and timeframe of house dust mite (HDM) sensitization development in patients in Ukraine as well as the period when treatment of such patients would be most effective. Methods The data of the multiplex allergy test Alex2 was collected from 20,033 patients. To determine age specifics of sensitization, descriptive statistics were used. Bayesian Network analysis was used to build probabilistic patterns of individual sensitization. Results Patients from Ukraine were most often sensitized to HDM allergens of group 1 (Der p 1, Der f 1) and group 2 (Der p 2, Der f 2) as well as to Der p 23 (55%). A considerable sensitivity to Der p 5, Der p 7 and Der p 21 allergens was also observed. The overall nature of sensitization to HDM allergens among the population of Ukraine is formed within the first year of life. By this time, there is a pronounced sensitization to HDM allergens of groups 1 and 2 as well as to Der p 23. Significance of sensitization to Der p 5, Der p 7 and Der p 21 allergens grows starting from the age of 3–6. Bayesian Network data analysis indicated the leading role of sensitization to Der p 1 and Der f 2. While developing the sensitivity to group 5 allergens, the leading role may belong to Der p 21 allergen. Conclusion The results obtained indicate the importance of determining the sensitization profile using the multi-component approach. A more detailed study of the optimal age for AIT prescription is required as the pattern of sensitization to HDMs is formed during the first year of life.

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Evaluación de la sensibilización a Der p 1 y Der p 2 en una población pediátrica del Norte de Portugal

Abstract: Der p 1 and Der p 2 are dominant allergens in our population and there may be benefits in determining these molecular allergen levels in patients with a positive prick-test and a clinical indication for sIT prior to a decision of initiating sIT or not.

Cited by 4 publications

References 31 publications

Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion

Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion

“Cut-Off Value of Sige To D. Pteronyssinus in Double Negative Patients Der P 1 and Der P2 and Its Clinical Repercussion”.

Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens

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