The objective of the chapter is to analyze the main challenges of the formation of human capital at the postgraduate level in the digital era in order to determine the main competencies to be developed by students. The postgraduate degree is the educational level oriented towards the development of professional skills of human capital that allows them to be autonomous professionals prepared to perform effectively and efficiently in a digital world. The challenges that the Fourth Industrial Revolution has established for the educational system: Incorporation of technological impact in academic training; formulation of proposals to innovate in training processes; generation of knowledge based on social innovation. Students who access the postgraduate level need to acquire skills that allow them to adapt to a work environment in constant technological evolution, in addition to acquiring both technical knowledge and relevant social skills. Digital leadership has become a strategic factor for organizational success in the era of technological transformation