Evaluación del perfil de sensibilidad in vitro de aislamientos clínicos de Trichophyton mentagrophytes y Trichophyton rubrum en Santiago, Chile

Jarabrán, María Cristina Díaz; González, Pablo Díaz; Rodríguez, José E. Vera; Muñoz, Alfonso Javier Carrillo

doi:10.1016/j.riam.2013.12.002

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…On the other hand, the topical antifungals were grouped separately, in the other two groups. [17]. On the other hand, in the present study, seven of the isolates were resistant to itraconazole, with a MIC 50 of 1.00 µg/mL These results are in concordance with Torres., et al…”

Section: Determination Of the Minimal Inhibitory Concentrationsupporting

confidence: 92%

In vitro Activity of Amorolfine, Ciclopirox, Itraconazole and Terbinafine Against Aspergillus versicolor as Agent of Onychomycosis

Ramírez-Hernández¹,

Montero-Arias²,

Vargas-Ovalle³

et al. 2020

Act Scie Micro

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Cases of onychomycosis caused by non-dermatophyte filamentous fungi have increased over the years. It is worth noting that this group of fungi is resistant to fluconazole, thus the importance of determining the in vitro susceptibility patterns to the antifungals available. We determined the minimal inhibitory concentration of amorolfine, ciclopirox, itraconazole and terbinafine using the microdilution method M38-A, as described by the Clinical Laboratory and Standards Institute, of 13 isolates of Aspergillus versicolor obtained from onychomycosis. The final concentrations were: 0.13-64 μg/mL for amorolfine and terbinafine, 0.06 -32 μg/mL for ciclopirox and 0.03-16 μg/mL for itraconazole. Also, we determined the interaction of these drugs by the checkerboard method.The MIC 50 and MIC 90 were ≥ 64.00 and ≥ 64.00 µg/mL for amorolfine, 4.00 and 8.00 µg/mL for ciclopirox, 1.00 and 1.80 µg/mL for itraconazole and 0.50 and 1.36 µg/mL for terbinafine, respectively. Regarding the combination of antifungals, 15.38% of the combinations of ciclopirox-itraconazole presented synergism, while the rest of the combinations showed no interaction. Thus, in vitro susceptibility testing indicates that terbinafine exhibited the highest antifungal activity and amorolfine the lowest against A.versicolor. Also, combining treatments enhances the activity of the drugs, proving a possible alternative for successful treatment of onychomycosis caused by this fungus.

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Section: Determination Of the Minimal Inhibitory Concentrationsupporting

confidence: 92%

In vitro Activity of Amorolfine, Ciclopirox, Itraconazole and Terbinafine Against Aspergillus versicolor as Agent of Onychomycosis

Ramírez-Hernández¹,

Montero-Arias²,

Vargas-Ovalle³

et al. 2020

Act Scie Micro

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“…The antifungal activity of M1-M6 was tested against Trichophyton mentagrophytes, which is an anthropophilic, pathogenic fungus that causes tinea capitis of the feet and body and invades the nail surface of both humans and animals [63,64]. The results show that the EC 50 values for cannabis oils are in the range of 89-240 µg/mL (see the last column in Table 3).…”

Section: Evaluation Of Antifungal Activitymentioning

confidence: 99%

Study of Cannabis Oils Obtained from Three Varieties of C. sativa and by Two Different Extraction Methods: Phytochemical Characterization and Biological Activities

Pino¹,

Espinoza

Villena

et al. 2023

Plants

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Currently, much effort is being placed into obtaining extracts and/or essential oils from Cannabis sativa L. for specific therapeutic purposes or pharmacological compositions. These potential applications depend mainly on the phytochemical composition of the oils, which in turn are determined by the type of C. sativa and the extraction method used to obtain the oils. In this work, we have evaluated the contents of secondary metabolites, delta-9-tetrahydrocannabinol (THC), and cannabidiol (CBD), in addition to the total phenolic, flavonoids, and anthraquinone content in oils obtained using solid–liquid extraction (SLE) and supercritical fluid extraction (SCF). Different varieties of C. sativa were chosen by using the ratio of THC to CBD concentrations. Additionally, antioxidant, antifungal and anticancer activities on different cancer cell lines were evaluated in vitro. The results indicate that oils extracted by SLE, with high contents of CBD, flavonoids, and phenolic compounds, exhibit a high antioxidant capacity and induce a high decrease in the cell viability of the tested breast cancer cell line (MCF-7). The observed biological activities are attributed to the entourage effect, in which CBD, phenols and flavonoids play a key role. Therefore, it is concluded that the right selection of C. sativa variety and the solvent for SLE extraction method could be used to obtain the optimal oil composition to develop a natural anticancer agent.

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“…gypseum and M. canis due to their high incidence in superficial fungal infections (Ayatollahi Mousavi and Kazemi, 2015). Species of Trichophyton account for as many as 70% of all dermatophyte infections (Jarabrán et al, 2015;Mukherjee et al, 2003); M. gypseum, although saprophytic in immunocompetent individuals, produces important infections in immunocompromised patients due to its keratinolytic potential (Tambekar et al, 2007).…”

Section: Antifungal Activity Of Baccharis Extractsmentioning

confidence: 99%

Antifungal activity of phytotherapeutic preparation of Baccharis species from argentine Puna against clinically relevant fungi.

Carrizo

Zampini

Sayago

et al. 2020

Journal of Ethnopharmacology

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Evaluación del perfil de sensibilidad in vitro de aislamientos clínicos de Trichophyton mentagrophytes y Trichophyton rubrum en Santiago, Chile

Cited by 5 publications

References 24 publications

In vitro Activity of Amorolfine, Ciclopirox, Itraconazole and Terbinafine Against Aspergillus versicolor as Agent of Onychomycosis

In vitro Activity of Amorolfine, Ciclopirox, Itraconazole and Terbinafine Against Aspergillus versicolor as Agent of Onychomycosis

Study of Cannabis Oils Obtained from Three Varieties of C. sativa and by Two Different Extraction Methods: Phytochemical Characterization and Biological Activities

Antifungal activity of phytotherapeutic preparation of Baccharis species from argentine Puna against clinically relevant fungi.

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