Evaluación del valor de la proteína C reactiva y de la procalcitonina en la predicción de infección y mortalidad en los niños quemados

Rosanova, María Teresa; Tramonti, Nidia; Taicz, Moira; Martiren, Soledad; Basílico, Hugo; Signorelli, Cecilia; Buchovsky, Ana; Lede, Roberto

doi:10.5546/aap.2015.36

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…However, the role of age in the post-traumatic inflammatory response in children remains unknown. Following pediatric burn injury, neither CRP nor PCT necessarily correlated with an increased mortality (45). Consequently, further studies investigating the systemic inflammatory profile after burn injury combined with severe trauma in children are necessary.…”

Section: Acute Systemic Inflammatory Markersmentioning

confidence: 96%

Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research

et al. 2021

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Severe trauma is the most common cause of mortality in children and is associated with a high socioeconomic burden. The most frequently injured organs in children are the head and thorax, followed by the extremities and by abdominal injuries. The efficient and early assessment and management of these injuries is essential to improve patients' outcome. Physical examination as well as imaging techniques like ultrasound, X-ray and computer tomography are crucial for a valid early diagnosis. Furthermore, laboratory analyses constitute additional helpful tools for the detection and monitoring of pediatric injuries. Specific inflammatory markers correlate with post-traumatic complications, including the development of multiple organ failure. Other laboratory parameters, including lactate concentration, coagulation parameters and markers of organ injury, represent further clinical tools to identify trauma-induced disorders. In this review, we outline and evaluate specific biomarkers for inflammation, acid-base balance, blood coagulation and organ damage following pediatric polytrauma. The early use of relevant laboratory markers may assist decision making on imaging tools, thus contributing to minimize radiation-induced long-term consequences, while improving the outcome of children with multiple trauma.

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Section: Acute Systemic Inflammatory Markersmentioning

confidence: 96%

Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research

et al. 2021

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Use of procalcitonin as a biomarker for sepsis in pediatric burns

Öncül

Dalgıç²,

Demir³

et al. 2023

Eur J Pediatr

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Introduction: Infection and sepsis continue to be the leading cause of morbidity and death in burn injuries. Diagnosing sepsis in burns is challenging as signs and symptoms of sepsis are not speci c and overlap with those related to the burn injury. While use of procalcitonin (PCT) as a biomarker is recommended for diagnosing sepsis in burns, evidence for children with burns is scarce. In this study, we aimed to investigate the role of PCT for distinguishing sepsis in pediatric burns.Methods: A prospective observational study was conducted in a single pediatric burn unit. Children hospitalized with burns ≤30% of total body surface area were included while patients with chemical burn, inhalation injury or concomitant chronic disease were excluded. Patients were classi ed into three groups for sepsis, systemic in ammatory response syndrome (SIRS) or controls using the American Burn Association (ABA) criteria. Predictive role of C-reactive protein (CRP) and PCT was investigated for distinguishing sepsis.Results: Seventy-two patients were included in the study. Median total body surface area (TBSA) size was 12% (2.0-28.5%) and median abbreviated burn severity index (ABSI) score was 3 (2-7). Median length of burn unit stay was 9.5 days (1-59 days). Sepsis was diagnosed in 11 patients (15.2%) and SIRS was present in 23 patients (40.0%), whereas 38 patients (52.8%) had neither SIRS nor sepsis (control group).Receiver operating characteristic analysis revealed that CRP and PCT levels distinguished sepsis patients from non-sepsis patients while PCT had a higher positive predictive value (64.3% vs 47.6%). Optimal cutoff values of CRP and PCT for distinguishing sepsis were 66.75 mg/L and 2.54 ng/mL. Conclusions: PCT levels could distinguish sepsis in children with burn injuries, performing better than CRP levels. Con rmatory studies are needed to evaluate the development of sepsis and role of PCT for diagnosing sepsis in pediatric burn patients.

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C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children

Horvat

Bell

Kantawala

et al. 2019

Clin Pediatr (Phila)

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Our objective was to determine if C-reactive protein (CRP) and ferritin values alone and in combination are associated with mortality among hospitalized children. All hospitalized patients at our institution with a CRP or ferritin assay in 2015 and 2016 were included. Area under the receiver operating curves (AUROC) were examined, optimal cut-points determined, and patients were stratified into low-, intermediate-, or high-risk groups based on elevation of zero, one, or both biomarkers. A total of 14 928 CRP and 653 ferritin values were obtained, with both obtained for 172 patients. AUROC for maximum CRP value was 0.76 (0.68-0.85) with a cut-point of 7.1 mg/dL for in-hospital mortality and 0.90 (0.83-0.98) for maximum ferritin with a cut-point of 373 ng/mL. Elevation of both ferritin and CRP was associated with the highest inpatient mortality (21.7%) and greatest organ dysfunction, followed by either biomarker alone. Additional prospective study of these biomarkers in combination is warranted.

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Evaluación del valor de la proteína C reactiva y de la procalcitonina en la predicción de infección y mortalidad en los niños quemados

Cited by 5 publications

References 21 publications

Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research

Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research

Use of procalcitonin as a biomarker for sepsis in pediatric burns

C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children

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Evaluación del valor de la proteína C reactiva y de la procalcitonina en la predicción de infección y mortalidad en los niños quemados

Cited by 5 publications

References 21 publications

Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research

Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research

Use of procalcitonin as a biomarker for sepsis in pediatric burns

C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children

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Product

Resources

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Evaluación del valor de la proteína C reactiva y de la procalcitonina en la predicción de infección y mortalidad en los niños quemados