The safety of blood used for transfusions has historically been the main focus of the international health community. In the Americas, during the first decade of the 21st Century, the attention switched to the patients who need transfusions and to the individuals who donate blood, that is, to transfusion safety. Timely and universal access to blood components implied adequate availability to sufficient blood components by patients who require transfusions in every hospital of every country. Clinical conditions and local non-medical factors influence decisions to admit and transfuse ill individuals. Locally-developed pertinent transfusion guidelines contribute to better estimate blood needs. Replacement blood donation hinders access to blood stocked in the hospitals blood banks and results in excessive component expiry and financial losses. Focusing on patient transfusion needs and on patient outcomes permits implementing national blood collection, processing and distribution, in consonance with the national health system. Analyses of general health conditions, by using the national Human Health Indexes, and the operational characteristics of blood services, by using the blood center density index, permit identification of locally pertinent interventions to improve transfusion safety. For this article, the analytical approaches used in Ibero-America were applied to blood data from SouthEast Asian and African countries. Data collection and validation were identified as priorities for Asian countries. Estimating blood component requirements at the local level and adjusting blood collection, processing and distribution systems are important in Africa.