Evaluasi Performa Support Vector Machine Classifier Terhadap Penyakit Mental

Abstract

Expression of genes found in the brains of autism, bipolar, and schizophrenia patients identified as overlapping. The overlap is a state in which the values of genes are similar. This paper aims to determine the best performance of support vector machines algorithm in classifying autism, bipolar, and schizophrenia based on the expression of genes using genome-wide association studies data. Using three support vector machine kernels, this study evaluates the performance of gaussian, laplacian, and sigmoid for genome-wide association studies datasets. The datasets were obtained from Psychiatric Genomics Consortium publications, where 660 data were taken with each disorder consisting of 220 data. This study proposes an optimal kernel for one-against-one and one-against-all multiclass support vector machine, and the performance is evaluated using accuracy. The study results show that the Gaussian kernel has the best accuracy performance compared to other support vector machines kernels in classifying genome-wide association studies data of autism, bipolar, and schizophrenia as early diagnosis.

Integration of genomic databases and bioinformatic approach to identify genomic variants for sjogren’s syndrome on multiple continents

“…Gene variation frequently links disease progression and pathogenesis, including Sjogren syndrome. One website that covers gene variation is Genome-Wide Association Studies (GWAS) (Furqan et al, 2020). GWAS is a database with single nucleotide polymorphism (SNP) search results in the genomes of several humans as genetic markers that are used in predicting a disease disorder (Bush & Moore, 2012).…”

Identifikasi Variasi Dan Ekspresi Gen Pada Stroke Iskemik Dengan Pendekatan Bioinformatika

“…Riwayat stroke dalam keluarga dikaitkan dengan prevalensi dan kejadian stroke yang lebih tinggi. Faktor genetik diketahui mempengaruhi berbagai aspek stroke iskemik, termasuk perubahan risiko terjadinya stroke individu, modulasi respon pengobatan, dan efektivitas pemulihan fungsional pasca stroke(Zhang et al, 2023).Salah satu sumber informasi yang membahas variasi gen adalah Genome-Wide AssociationStudies (GWAS)(Furqan et al, 2020).yang terkait dengan stroke iskemik. Single-Nucleotide Polymorphisms (SNP) yang terkait dengan penyakit stroke iskemik diperoleh dari National Human Genome Research Institute (NHGRI) GWAS Katalog yang diunduh pada tanggal 15 Oktober 2023 dengan istilah " ischemic stroke " (EFO ID: EFO_0002690) (GWAS, n.d.).…”

Face Expression Recognizer Dengan Convolutional Neural Network Untuk Membantu Penderita Autisme Mengenali Ekspresi Wajah Seseorang

“…Gangguan autisme mengacu pada adanya gangguan fungsi otak, sehingga terjadi perbedaan cara berpikir, merasakan sesuatu, serta berperilaku. Autisme berasal dari kata "auto" yang berarti berdiri sendiri [1]. Dalam hal ini, penderita autisme merasa memiliki kehidupan pada dunianya sendiri.…”