Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study

Sidhu, Harpreet Singh; Srinivasa, R; Sadhotra, Akshay

doi:10.1016/j.eplepsyres.2017.10.016

Cited by 40 publications

(28 citation statements)

References 36 publications

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“…After 6 and 12 months of treatment with LTG, seizure frequency gradually decreased in all patients and confirmed the value of LTG in treating epilepsy, which was consistent with previous studies [13,14] . Most importantly, our study also discovered that seizure frequency in the low AMPA group was markedly lower than that in the high AMPA group, suggesting that AMPA receptor levels might have an impact during LTG treatment in epilepsy.…”

Section: Discussionsupporting

confidence: 91%

Effects of Cerebrospinal Fluid AMPA Receptor Levels on the Clinical Efficacy of Lamotrigine in Epilepsy Treatment

Tan

Liu

Wei

et al. 2019

Preprint

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Background: Epilepsy is one of the greatest health burdens in the world, and it deeply impacts the mental and physical health of the affected population. Some individuals can completely recover through effective treatment, while others have difficulty recovering and even have mortality risks during seizure attacks. Thus, we explored the effects of cerebrospinal fluid AMPA receptor levels on the clinical efficacy of lamotrigine in epilepsy treatment. We believe our work might have implications in epilepsy treatment. Methods: Seventy cases of epilepsy diagnosed in our hospital were selected for this study from December 2016 to October 2018. The AMPA receptor content of patients in cerebrospinal fluid was determined by enzyme-linked immunosorbent assay. The patients were placed into a high AMPA group (n=34) and a low AMPA group (n=36) according to the median value at 4.08 ng/ml. Clinical efficacy and the incidence of adverse reactions were compared between the two groups. Results: Before treatment, there was no significant difference in seizure frequency between the two groups (P>0.05). After treatment for 6 and 12 months, the seizure frequencies of the two groups were gradually reduced (P<0.05). Moreover, the number of seizures in the low AMPA group was significantly lower than that in the high AMPA group (P<0.05). The response rate of the high AMPA group was 79.41%, which was significantly lower than that of the low group AMPA (χ2=6.055, P=0.048). The improvement in electroencephalogram in the high AMPA group was 67.65%, which was significantly lower than that in the low AMPA group (χ2=4.686, P=0.030). However, there was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.202, P=0.653). Conclusions: AMPA receptor plays an important role in the development of epilepsy, and lamotrigine treatment was more efficacious in patients with low AMPA receptor levels.

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Section: Discussionsupporting

confidence: 91%

Effects of Cerebrospinal Fluid AMPA Receptor Levels on the Clinical Efficacy of Lamotrigine in Epilepsy Treatment

Tan

Liu

Wei

et al. 2019

Preprint

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“…It was shown recently that the menstrual disturbances noted in women who initially used VPA are reversible when VPA is switched to lamotrigine. 29 Future studies should bring more unequivocal findings related to the potential interventions that might improve quality of life among women with epilepsy who suffer from menstrual irregularity and its consequences.…”

Section: Discussionmentioning

confidence: 99%

Menstrual disorders and their determinants among women with epilepsy

Bosak

Słowik

Turaj

2018

NDT

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IntroductionThe purpose of the present study was to assess the prevalence and determinants of menstrual cycle disorders among women with epilepsy.Materials and methodsThe study included consecutive women with epilepsy who visited a university epilepsy clinic. A number of variables, including demographics, characteristics of epilepsy and its treatment, and data related to reproductive health (regularity of menstrual cycle, number of pregnancies and childbirths), were collected from medical records, seizure diaries, and a dedicated questionnaire.ResultsThe study involved 271 women with epilepsy. Focal epilepsy was diagnosed in 182 (67.2%) patients; 108 (39.8%) women had rare seizures (<1 per year), and 164 patients (60.5%) were on monotherapy. Menstrual abnormalities were found in 78 patients (28.8%). Independent variables associated with irregular cycle included younger age at onset of epilepsy (OR=0.95 per 1-year increase; P=0.008), current use of clonazepam (OR=5.36; P=0.010), and chronic use of medication(s) other than antiepileptic drug(s) (AEDs; OR=2.48; P=0.003). Childbirth rate was low in our cohort (0.50 per patient); independent predictors of being childless in studied patients included younger age, presence of menstrual disorders, and greater number of currently used AEDs.ConclusionMenstrual disturbances were present in 28.8% of studied women with epilepsy. Increased prevalence of menstrual abnormalities was associated with epilepsy itself (younger age at onset of epilepsy) and its treatment (ongoing use of clonazepam), as well as with chronic use of medications other than AEDs.

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“…This advice is based on a study125 of 16 women using 30 µg EE/150 µg LNG and lamotrigine for 6 weeks which found a modest increase in levonorgestrel clearance and changes in serum FSH and LH. The clinical significance in terms of contraceptive effectiveness is unknown.…”

Section: How Effective Is Chc?mentioning

confidence: 99%

FSRH Guideline (January 2019, amended October 2023) Combined Hormonal Contraception

2019

BMJ Sex Reprod Health

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Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study

Cited by 40 publications

References 36 publications

Effects of Cerebrospinal Fluid AMPA Receptor Levels on the Clinical Efficacy of Lamotrigine in Epilepsy Treatment

Effects of Cerebrospinal Fluid AMPA Receptor Levels on the Clinical Efficacy of Lamotrigine in Epilepsy Treatment

Menstrual disorders and their determinants among women with epilepsy

FSRH Guideline (January 2019, amended October 2023) Combined Hormonal Contraception

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