Evaluating and palliating hiccups

Jatoi, Aminah

doi:10.1136/bmjspcare-2022-003676

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Chemotherapy-induced hiccups are understudied. However, in some patients with cancer, hiccups spawn sleep deprivation, fatigue, pain in the chest and abdomen, poor oral intake, aspiration, and even death [1]. Certain cancer chemotherapy agents, such as cisplatin and oxaliplatin, either with or without dexamethasone, can cause hiccups [1].…”

Section: Introductionmentioning

confidence: 99%

“…However, in some patients with cancer, hiccups spawn sleep deprivation, fatigue, pain in the chest and abdomen, poor oral intake, aspiration, and even death [1]. Certain cancer chemotherapy agents, such as cisplatin and oxaliplatin, either with or without dexamethasone, can cause hiccups [1]. The cyclical nature of hiccups, which, in effect, occur with the administration of each cycle of cancer chemotherapy, can conceivably generate a cumulative burden of hiccups and hiccup-associated symptoms [2].…”

Section: Introductionmentioning

confidence: 99%

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What percentage of patients with cancer develop hiccups with oxaliplatin- or cisplatin-based chemotherapy? a compilation of patient-reported outcomes

2023

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Background Chemotherapy-induced hiccups are understudied but can cause sleep deprivation, fatigue, pain in the chest and abdomen, poor oral intake, aspiration, and even death. As a critical next step toward investigating better palliative methods, this study reported patient-reported incidence of hiccups after oxaliplatin- or cisplatin-based chemotherapy. Methods The current study relied on 2 previous studies that sought to acquire consecutive direct patient report of hiccups among patients who had recently received chemotherapy with cisplatin or oxaliplatin. These patient-reported data in conjunction with information from the medical record are the focus of this report. Results Of 541 patients, 337 were successful contacted by phone; and 95 (28%; 95% CI: 23%, 33%) of these contacted patients reported hiccups. In univariable analyses, male gender (odds ratio (OR): 2.17 (95% confidence ratio (95% CI): 1.30, 3.62); p = 0.002), increased height (OR: 1.03 (95% CI: 1.00, 1.06); p = 0.02), and concomitant aprepitant/fosaprepitant (OR: 2.23 (95% CI: 1.31, 3.78); p = 0.002) were associated with hiccups. In multivariable analyses, these statistically significant associations persisted except for height. Conclusions These patient-reported data demonstrate that oxaliplatin- or cisplatin-induced hiccups occur in a notable proportion of patients with cancer. Male gender and concomitant aprepitant/fosaprepitant appear to increase risk.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

What percentage of patients with cancer develop hiccups with oxaliplatin- or cisplatin-based chemotherapy? a compilation of patient-reported outcomes

2023

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“…Similarly, metastatic disease to the diaphragm or brain stem can result in frequent, persistent hiccups. 4…”

Section: Introductionmentioning

confidence: 99%

“…Similarly, metastatic disease to the diaphragm or brain stem can result in frequent, persistent hiccups. 4 Hiccups are the result of spasms of the diaphragm and other thoracic musculature. These spasms cause an abrupt closure of the glottis, creating the pathognomonic "hic" sound of a hiccup.…”

Section: Introductionmentioning

confidence: 99%

Healthcare Providers’ Experiences with Hiccups in Patients with Cancer: Report of a United States National Survey

Wieland

Martin

Jatoi

2022

Am J Hosp Palliat Care

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Hiccups occur in 15-40% of cancer patients, but previous research has not sought the perspectives of cancer healthcare providers. The objective of this research is to report on United States cancer healthcare providers’ awareness of their patients’ hiccups and these healthcare providers' perceived need for further palliation options. A survey was developed and then distributed throughout the United States via email to cancer healthcare providers; results are reported descriptively. Six hundred eighty-four cancer healthcare providers completed 2 eligibility screening questions which required them to have cared for an adequate number of patients (> 10 in the past 6 months) with “clinically significant” hiccups (defined as hiccups that persisted for >48 hours or occurred from cancer or from cancer care). Of 113 eligible healthcare providers, 90 completed the survey. Healthcare providers described hiccups as associated with stress/anxiety, fatigue, sleep problems, and decreased work/school productivity. In 49% of patients, healthcare providers initially prescribed medications (commonly chlorpromazine or baclofen); 18% expressed dissatisfaction with current palliation. Proffered comments included, “When current therapies do not work, it can be very demoralizing to our patients; ” and “…my biggest complaint is that current treatments also come with their own side effects which can be quite severe.” Discordance appears to exist between the percentage of cancer patients with hiccups and the percentage of cancer healthcare providers with awareness of their patients’ hiccups. Nonetheless, healthcare providers described notable hiccup-associated symptoms in their patients and a need for more palliative options.

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Hiccups in patients with cancer: a multi-site, single-institution study of etiology, severity, complications, interventions, and outcomes

et al. 2022

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Background To our knowledge, previous studies have not investigated hiccups in patients with cancer with detailed patient-level data with the goal of capturing a broad spectrum of hiccup symptomatology. Methods This multi-site, single institution study examined consecutive medical records to better understand hiccups in patients with cancer. Results A total of 320 patients are the focus of this report. The median age of patients when hiccups were first reported in the medical record was 63 years (range: 21, 97 years) with 284 (89%) men and 36 (11%) women. The most common diagnose was gastrointestinal cancer. Hiccups most frequently occurred daily, as seen in 194 patients (62%), and the most common duration was less than 1 week, as seen in 146 patients (47%). However, nine patients had had daily hiccups for greater than 6 weeks, and 5 had symptoms for years. Cited etiology was non-chemotherapy medications in 36 (11%) and cancer chemotherapy in 19 (6%). Complications occurred in approximately a third and included insomnia in 51 patients (16%); hospitalization or emergency department visit in 34 (11%); and musculoskeletal pain in 23 (7%). Baclofen was the single most prescribed agent for hiccup palliation, but 100 patients received more than one medication. Medical procedures, which included acupuncture, paracentesis, or phrenic nerve block, were performed in 5 patients. In 234 patients (73%), the medical record documented hiccup cessation. Conclusions Hiccups appear to be highly problematic in a small subset of patients with cancer with no well-defined palliative approaches.

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Evaluating and palliating hiccups

Cited by 3 publications

References 11 publications

What percentage of patients with cancer develop hiccups with oxaliplatin- or cisplatin-based chemotherapy? a compilation of patient-reported outcomes

What percentage of patients with cancer develop hiccups with oxaliplatin- or cisplatin-based chemotherapy? a compilation of patient-reported outcomes

Healthcare Providers’ Experiences with Hiccups in Patients with Cancer: Report of a United States National Survey

Hiccups in patients with cancer: a multi-site, single-institution study of etiology, severity, complications, interventions, and outcomes

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