Evaluating Antibiograms To Monitor Drug Resistance

El-Azizi, Mohamed; Mushtaq, Adnan; Drake, Cheryl; Lawhorn, Jerry; Barenfanger, Joan; Verhulst, Steven J.; Khardori, N.M.

doi:10.3201/eid1108.050135

Cited by 19 publications

(19 citation statements)

References 6 publications

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“…The continuous surveillance of antibiotic resistance trends in bacteria isolated from hospital-acquired infections is essential for the selection of adequate initial empiric therapy [6,7]. The laboratory-based antibiograms is efficacious as a guide for the rational selection of antimicrobial therapy, and to alert healthcare providers to the presence of unusual or emerging antimicrobial mechanisms [8]. The evaluation of antimicrobial resistance in gram-negative bacterial strains in two Mexican hospitals during 2005–2010 is presented.…”

Section: Resultsmentioning

confidence: 99%

Resistance trends in gram-negative bacteria: surveillance results from two Mexican hospitals, 2005–2010

et al. 2012

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BackgroundHospital-acquired infections caused by multiresistant gram-negative bacteria are difficult to treat and cause high rates of morbidity and mortality. The analysis of antimicrobial resistance trends of gram-negative pathogens isolated from hospital-acquired infections is important for the development of antimicrobial stewardship programs. The information obtained from antimicrobial resistant programs from two hospitals from Mexico will be helpful in the selection of empiric therapy for hospital-acquired gram-negative infections.FindingsTwo thousand one hundred thirty two gram-negative bacteria collected between January 2005 and December 2010 from hospital-acquired infections occurring in two teaching hospitals in Mexico were evaluated. Escherichia coli was the most frequently isolated gram-negative bacteria, with >50% of strains resistant to ciprofloxacin and levofloxacin. Klebsiella spp. showed resistance rates similar to Escherichia coli for ceftazidime (33.1% vs 33.2%), but exhibited lower rates for levofloxacin (18.2% vs 56%). Of the samples collected for the third most common gram-negative bacteria, Pseudomonas aeruginosa, >12.8% were resistant to the carbapenems, imipenem and meropenem. The highest overall resistance was found in Acinetobacter spp. Enterobacter spp. showed high susceptibility to carbapenems.ConclusionsE. coli was the most common nosocomial gram-negative bacilli isolated in this study and was found to have the second-highest resistance to fluoroquinolones (>57.9%, after Acinetobacter spp. 81.2%). This finding represents a disturbing development in a common nosocomial and community pathogen.

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Section: Resultsmentioning

confidence: 99%

Resistance trends in gram-negative bacteria: surveillance results from two Mexican hospitals, 2005–2010

et al. 2012

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“…The reason is that the suppurative infection of the skin, ear, and eye are common occurrences in hospitalized patients as well as in the outpatients department. Furthermore wound infection is regarded as the most common nosocomial infection among surgical patients 8 . It has been associated with increased trauma care, prolonged hospitals stay, and treatment 9 .…”

Section: Discussionmentioning

confidence: 99%

Bacteriological Profiles of Pus with Antimicrobial Sensitivity Pattern at a Teaching Hospital in Dhaka City

Khanam

Islam

Sharif

et al. 2018

Bangladesh J. Infect. Dis.

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Background: The human skin and soft tissue infections (SSTIs) caused by microbial pathogens during or after trauma, burn injuries, and surgical procedures result in the production of pus, a white to yellow fluid comprised of dead WBCs, cellular debris, and necrotic tissues.Objective: The purpose of the present study was to see the frequency and distribution of bacteria isolated from pus and sensitivity pattern.Methodology: This retrospective study was conducted in the Department of Microbiology at Shaheed Suhrawardy Medical College, Dhaka from January 2016 to December 2016 for a period of one (01) year. The pus samples were collected from the patients who were visited in outpatient department and were admitted at IPD in Shaheed Suhrawardy Medical College Hospital (ShSMCH), Dhaka with skin and soft tissue infection. Bacteria were detected by culture and biochemical test and antibiotic susceptibility test done by disc diffusion method.Result: A total number of 212 patients presented with wound infection or pus were recruited for this study. Among 212 patients majority were in the age group of 20 to 40 years which was 89(42.0%) cases. Interestingly male was predominant than female which was 119(56.1%) cases and 93(43.9%) cases respectively. aerobic culture was positive in majority cases which were 131(61.8%) cases.Conclusion: In conclusion the most common isolated bacteria after aerobic culture of pus is the Staphylococcus aureus. However the gram positive cocci is less in number than gram negative bacilli.Bangladesh Journal of Infectious Diseases 2018;5(1):10-14

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“…The spread of resistance has repeatedly been shown to be associated with antibiotic therapy, which once again stresses the need for rational use of these drugs. [1,2] Reliable statistics on antibiotic resistance and policies that are mandatory to control spread of resistant pathogens are available from the developed nations. These data generated by large surveillance studies in countries such as the USA, Europe, Australia, etc.…”

Section: Need For Antibiotic Prescription Guidelines and Policiesmentioning

confidence: 99%

“…There is, therefore, a deÞ nite and felt need for national policies or guidelines to address this issue critically. [2] …”

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confidence: 99%

Need for national/regional guidelines and policies in India to combat antibiotic resistance

Lakshmi

2008

Indian J Med Microbiol

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Evaluating Antibiograms To Monitor Drug Resistance

Cited by 19 publications

References 6 publications

Resistance trends in gram-negative bacteria: surveillance results from two Mexican hospitals, 2005–2010

Resistance trends in gram-negative bacteria: surveillance results from two Mexican hospitals, 2005–2010

Bacteriological Profiles of Pus with Antimicrobial Sensitivity Pattern at a Teaching Hospital in Dhaka City

Need for national/regional guidelines and policies in India to combat antibiotic resistance

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