Evaluating antibody response pattern in asymptomatic virus infected pregnant females: Human well-being study

Ali, Ashaq; Rashid, Zubia; Zhou, Jieqiong; Yousaf, Muhammad; Galani, Saddia; Ashraf, Asma; Al‐Ghanim, Khalid A.; Al-Suliman, Emin; Ahmed, Zubair; Farooq, Muhammad Umar; Virik, Promy; Kaimkhani, Zahid Ali; Al-Mulhm, Norah; Mahboob, Shahid; Men, Dong; Huang, Qiuxiang

doi:10.1016/j.jksus.2020.101255

Cited by 5 publications

(10 citation statements)

References 35 publications

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“…Co-morbidities are very common, however, in those with more aggressive illnesses, and these have especially included obesity and diabetes [ 1 , 2 , 12 , 14 , 19 , 28 , 30 , 31 , 33 , 34 , 38 – 40 , 42 , 68 , 79 – 81 , 88 , 89 , 94 , 96 , 105 , 110 , 116 ]. The anticipation of potential complications or the advanced nature of disease has led to a high rate of Caesarean section [ 1 – 3 , 10 , 21 – 23 , 25 , 29 – 32 , 35 , 38 – 42 , 51 , 55 , 56 , 59 , 60 , 68 , 74 – 77 , 82 , 87 , 94 , 101 , 105 , 107 , 109 – 115 , 117 – 129 ]. The frequencies of the latter have ranged 20–100%.…”

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

“…Further research is yet required to resolve this issue definitively. One must also consider that some patient series have included both laboratory-confirmed and clinically suspect patients [ 3 , 117 ].…”

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

“…In a large American cohort, perinatal COVID-19 infection was estimated at 2.6% [ 108 ]. Most studies, however, report an infrequency of neonatal SARS-CoV-2 infection at birth or thereafter despite maternal infection of varying severity [ 1 – 3 , 13 , 16 , 19 , 20 , 22 – 25 , 29 , 30 , 35 , 38 , 41 , 42 , 46 , 47 , 51 , 55 , 59 – 61 , 66 , 68 , 72 , 82 , 90 , 100 , 104 – 107 , 109 , 110 , 112 , 113 , 117 – 120 , 123 , 126 , 128 , 129 , 139 , 162 , 168 , 185 , 188 , 191 , 193 , 196 , 197 , 213 , 222 , 228 , 237 – 244 ]. The latter has also been evident despite some newborn exposure to maternal breastfeeding [ 82 , 118 , 127 , 136 , 241 ].…”

Section: Antenatal or Neonatal Infection With Sars-cov-2mentioning

confidence: 99%

“…Given the potential for diagnostic respiratory or other specimens to be collected either overly early or late, there is also the potential to miss a positive diagnosis based on viral RNA amplification or culture [137]. There is thus a potential role for serodiagnostic assays to provide support for viral infections retrospectively [117,[138][139][140][141]. Serodiagnosis can be complementary to other methods or can be used alone as the circumstances require.…”

Section: Diagnostic Dilemmatamentioning

confidence: 99%

“…For the determination of fetal infection, a time-honored approach could be the determination of IgMvirus specific antibody in newborn immediately in the postnatal period [52]. IgG-based serology for the newborn may be difficult to use since maternal IgG is capable of nonspecifically crossing the placenta for much of late pregnancy [73,117,[142][143][144][145]. Confirmatory or immunoblotting techniques would be useful to validate the likelihood of positive serodiagnoses in the research context at least.…”

Section: Diagnostic Dilemmatamentioning

confidence: 99%

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A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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The maternal-fetal/newborn unit is established at risk for COVID-19 infection. This narrative review summarizes the contemporary and cumulative publications which detail maternal infection, antenatal and newborn infections, and maternal/fetal/newborn management and prevention. There is a wide spectrum of maternal disease, but the potential for severe disease albeit in a minority is confirmed. COVID-19 carries risk for preterm delivery. Pregnant females can suffer multisystem disease, and co-morbidities play a significant role in risk. Congenital infection has been supported by several anecdotal reports, but strong confirmatory data are few. No typical congenital dysmorphisms are evident. Nevertheless, placental vascular compromise must be considered a risk for the fetus during advanced maternal infections. Clinical manifestations of newborn infection have been mild to moderate and relatively uncommon. Proven antiviral therapy is of yet lacking. The mode of delivery is a medical decision that must include patient risk assessment and patient directives. Both presymptomatic and asymptomatic mothers and offspring can complicate infection control management with the potential for spread to others in several regards. In the interim, infections of the maternal-fetal-newborn unit must be taken seriously both for the disease so caused and the potential for further dissemination of disease.

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Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

Section: Maternal Infection With Sars-cov-2mentioning

confidence: 99%

Section: Antenatal or Neonatal Infection With Sars-cov-2mentioning

confidence: 99%

Section: Diagnostic Dilemmatamentioning

confidence: 99%

Section: Diagnostic Dilemmatamentioning

confidence: 99%

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A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Cimolai

2021

SN Compr. Clin. Med.

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Seroprevalence of SARS‐CoV‐2 antibodies among first‐trimester pregnant women during the second wave of the pandemic in India

Sharma

Singh

Hillman

et al. 2022

Intl J Gynecology & Obste

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Objective Data on the immune response to SARS‐CoV‐2 during pregnancy are lacking and the potential role and effect of SARS‐CoV‐2 vaccination in pregnancy is yet to be completely investigated. Method This is a cross‐sectional observational study wherein pregnant women were tested for SARS‐CoV‐2 immunoglobulin M and immunoglobulin G levels, irrespective of their infective status or presence or symptomatology. Result Of the 220 pregnant women tested, 160 (72.7%) were SARS‐CoV‐2 IgG positive, 37 (16.8%) were SARS‐CoV‐2 IgM positive and 27 (16.9%) were both IgG and IgM positive. The average antibody titer found was 10.49 BAU/ml (±14.0) and 0.6 (±0.55) for anti‐SARS‐CoV‐2 IgG and IgM non neutralizing antibodies respectively. ROC analysis for SARS‐CoV‐2 IgG positivity showed a cut‐off value of 1.19 with a sensitivity of 99.3% (0.99 AUC, 95% CI) and specificity of 98.3% (0.99 AUC, 95% CI), respectively. Similarly, ROC analysis for SARS‐CoV‐2 IgM positivity showed a cut‐off value of 1 with a sensitivity of 97.3% (0.99 AUC, 95% CI) and specificity of 98.9% (0.99 AUC, 95% CI), respectively. Conclusion First trimester sero‐molecular screening suggests a high prevalence of COVID antibodies in the study population of pregnant women in the first trimester, without the patients being symptomatic.

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Impact of COVID-19 on Pregnancy and Maternal Health: An Update

et al. 2021

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Evaluating antibody response pattern in asymptomatic virus infected pregnant females: Human well-being study

Abstract: Graphical abstract

Cited by 5 publications

References 35 publications

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

A Comprehensive Analysis of Maternal and Newborn Disease and Related Control for COVID-19

Seroprevalence of SARS‐CoV‐2 antibodies among first‐trimester pregnant women during the second wave of the pandemic in India

Impact of COVID-19 on Pregnancy and Maternal Health: An Update

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