Epidemic outbreak (COVID-19, SARS-CoV-2) is an exceptional scenario of agri-food supply chain (AFSC) risk at the globalised level which is characterised by logistics' network breakdown (ripple effects), demand mismatch (uncertainty), and sustainable issues. Thus, the aim of this research is the modelling of the sustainable based multi-tier system for AFSC, which is managed through the different emerging application of Internet of things (IoT) technology. Different IoT technologies, viz., Blockchain, robotics, Big data analysis, and cloud computing, have developed a competitive AFSC at the global level. Competitive AFSC needs cautious incorporation of multi-tiers suppliers, specifically during dealing with globalised sustainability issues. Firms have been advancing towards their multi suppliers for driving social, environments and economical practices. This paper also studies the interrelationship of 14 enablers and their cause and effect magnitude as contributing to IoT-based food secure model. The methodology used in the paper is interpretative structural modelling (ISM) for establishing interrelationship among the enablers and Fuzzy-Decision-Making Trial and Evaluation Laboratory (F-DEMATEL) to provide the magnitude of the cause-effect strength of the hierarchical framework. This paper also provides some theoretical contribution supported by information processing theory (IPT) and dynamic capability theory (DCT). This paper may guide the organisation's managers in their strategic planning based on enabler's classification into cause and effect groups. This paper may also encourage the mangers for implementing IoT technologies in AFSC.