Content based image retrieval (CBIR), is an application of real-world computer vision domain where from a query image, similar images are searched from the database. The research presented in this paper aims to find out best features and classification model for optimum results for CBIR system.Five different set of feature combinations in two different color domains (i.e., RGB & HSV) are compared and evaluated using Neural Network Classifier, where best results obtained are 88.2% in terms of classifier accuracy. Color moments feature used comprises of: Mean, Standard Deviation,Kurtosis and Skewness. Histogram features is calculated via 10 probability bins. Wang-1k dataset is used to evaluate the CBIR system performance for image retrieval.Research concludes that integrated multi-level 3D color-texture feature yields most accurate results and also performs better in comparison to individually computed color and texture features.