Evaluating depression- and anxiety-like behaviors in non-human primates

Ausderau, Karla; Colman, Ricki J.; Kabakov, Sabrina; Schultz-Darken, Nancy; Emborg, Marina E.

doi:10.3389/fnbeh.2022.1006065

Cited by 5 publications

(3 citation statements)

References 147 publications

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“…Humans are most closely evolutionarily related to other simian species, including Old World Monkeys and New World Monkeys, which diverged ~30 and ~50 million years ago, respectively (Stevens et al, 2013 ; Yang et al, 2021a ). Macaques (Old World) and marmosets (New World) are the two most commonly used NHP species in anxiety research (Ausderau et al, 2023 ); each have a distinct utility for studying aspects of anxiety and fear based on their ethology and ecological niche (Capitanio, 2017 ; Capitanio & Emborg, 2008 ; Gunnar et al, 2015 ; Kalin & Shelton, 2003 ; Machado & Bachevalier, 2003 ; Miller et al, 2016 ; Mitchell & Leopold, 2015 ; Okano, 2021 ; Saito, 2015 ). NHPs have been leveraged to confirm the evolutionary conservation of brain-behavior relationships for many threat-relevant regions (Agustín-Pavón et al, 2012 ; Fox, Oler, Shackman et al, 2015a ; Izquierdo et al, 2005 ; Kalin et al, 2004 , 2007 ; Kenwood & Kalin, 2021 ; Machado & Bachevalier, 2008 ; Prather et al, 2001 ; Shiba et al, 2015 ).…”

Section: Capturing Fear and Anxiety Across Species: The Value Of Nont...mentioning

confidence: 99%

Understanding the heterogeneity of anxiety using a translational neuroscience approach

Drzewiecki,

Fox

2024

Cogn Affect Behav Neurosci

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Anxiety disorders affect millions of people worldwide and present a challenge in neuroscience research because of their substantial heterogeneity in clinical presentation. While a great deal of progress has been made in understanding the neurobiology of fear and anxiety, these insights have not led to effective treatments. Understanding the relationship between phenotypic heterogeneity and the underlying biology is a critical first step in solving this problem. We show translation, reverse translation, and computational modeling can contribute to a refined, cross-species understanding of fear and anxiety as well as anxiety disorders. More specifically, we outline how animal models can be leveraged to develop testable hypotheses in humans by using targeted, cross-species approaches and ethologically informed behavioral paradigms. We discuss reverse translational approaches that can guide and prioritize animal research in nontraditional research species. Finally, we advocate for the use of computational models to harmonize cross-species and cross-methodology research into anxiety. Together, this translational neuroscience approach will help to bridge the widening gap between how we currently conceptualize and diagnose anxiety disorders, as well as aid in the discovery of better treatments for these conditions.

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Section: Capturing Fear and Anxiety Across Species: The Value Of Nont...mentioning

confidence: 99%

Understanding the heterogeneity of anxiety using a translational neuroscience approach

Drzewiecki,

Fox

2024

Cogn Affect Behav Neurosci

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“…1,2,37,38 In this vein, McLaughlin and colleagues (2019) 39 have explored the neurodevelopmental mechanisms that underlie the boundary between adverse childhood experiences (ACE) in children and psychopathological outcomes in adulthood, including PTSD, major depressive episodes, anxiety, and cognitive impairment. Likewise, Ausderau and colleagues (2023) 40 compared the symptoms of depression and anxiety between humans, marmosets, Rhesus and long-tailed macaques. The vast majority of cited papers on this research focused on severe life experiences and their role in the development of aforementioned disorders, such as maternal separation, [41][42][43][44][45] early social withdrawal, 46,47 and early adverse rearing conditions.…”

Section: Introductionmentioning

confidence: 99%

Impacts of illegal trade on socio-emotional and behavioural skills in macaques

Rey,

Padrell,

Llorente

2024

F1000Res

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Decades of research have illuminated the consequences of early adverse rearing experiences in laboratory macaque populations. However, limited knowledge exists about the impact of traumatic episodes in non-laboratory environments. This study delves into the repercussions of illegal trade on socio-emotional and behavioural skills in five macaque species, all victims of poaching. We categorised their past experiences into seven aspects, encompassing maternal care and interactions with conspecifics. We assessed social engagement and cooperation by analysing social behaviours and employing the Social Responsiveness Scale. Emotional resilience was evaluated by measuring anxiety levels and the occurrence of abnormal behaviours, supported by a welfare questionnaire. Additionally, the introduction of Cattell’s 16PF questionnaire in macaques for the first time aimed to reveal the influence of traumatic experiences on their personality traits. Our findings emphasise the significance of early social exposure. The lack of juvenile social contact predicts reduced social behaviours and an inclination towards social avoidance in adulthood. Macaques raised by humans tend to exhibit more abnormal behaviours in social contexts, compromising their welfare. Deprivation of social exposure in infancy negatively impacts psychological stimulation and overall welfare. The duration of time spent in illegal trade correlates with heightened anxiety levels. Personality traits such as ‘Calmness’ and ‘Unfriendliness’ are influenced by rearing conditions, with macaques deprived of social interaction during their early years showing higher levels of introversion. In conclusion, the absence of social exposure during early life and hand-rearing due to illegal trade significantly shape macaques’ personality traits and their social and emotional skills.

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“…Anxiety-like behavior is an evolutionarily conserved behavior observed in different species, including mammals and fish (Ausderau et al 2023 ; Lang et al 2000 ; Kysil et al 2017 ). Several studies have demonstrated that Danio rerio (zebrafish) represents a powerful model to evaluate mechanisms controlling altered behavior such as anxiety (Assad et al 2020 ; Kalueff et al 2014 ; Maximino et al 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Brain oxidative stress mediates anxiety-like behavior induced by indomethacin in zebrafish: protective effect of alpha-tocopherol

Pinheiro,

de Deus

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Rationale Indomethacin (INDO) is a widely utilized non-steroidal anti-inflammatory drug (NSAID) with recognized effect on the central nervous system. Although previous reports demonstrate that prolonged treatment with indomethacin can lead to behavioral alterations such as anxiety disorder, the biochemical effect exerted by this drug on the brain are not fully understood. Objectives The aim of present study was to evaluate if anxiety-like behavior elicited by indomethacin is mediated by brains oxidative stress as well as if alpha-tocopherol, a potent antioxidant, is able to prevent the behavioral and biochemical alterations induced by indomethacin treatment. Methods Zebrafish were utilized as experimental model and subdivided into control, INDO 1 mg/Kg, INDO 2 mg/Kg, INDO 3 g/Kg, α-TP 2 mg/Kg, α-TP 2 mg/Kg + INDO 1 mg/Kg and α-TP + INDO 2 mg/Kg groups. Vertical distributions elicited by novelty and brain oxidative stress were utilized to determinate behavioral and biochemical alterations elicited by indomethacin treatment, respectively. Results Our results showed that treatment with indomethacin 3 mg/kg induces animal death. No changes in animal survival were observed in animals treated with lower doses of indomethacin. Indomethacin induced significant anxiogenic-like behavior as well as intense oxidative stress in zebrafish brain. Treatment with alpha-tocopherol was able to prevent anxiety-like behavior and brain oxidative stress induced by indomethacin. Conclusions Data presented in current study demonstrated for the first time that indomethacin induces anxiety-like behavior mediated by brain oxidative stress in zebrafish as well as that pre-treatment with alpha-tocopherol is able to prevent these collateral effects.

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Evaluating depression- and anxiety-like behaviors in non-human primates

Cited by 5 publications

References 147 publications

Understanding the heterogeneity of anxiety using a translational neuroscience approach

Understanding the heterogeneity of anxiety using a translational neuroscience approach

Impacts of illegal trade on socio-emotional and behavioural skills in macaques

Brain oxidative stress mediates anxiety-like behavior induced by indomethacin in zebrafish: protective effect of alpha-tocopherol

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