Evaluating different methods for kidney recellularization

Abstract

This study explores a potential solution to the shortage of kidneys for transplantation in end-stage renal disease (ESRD). Currently, kidney transplantation is the best option, but there aren't enough organs available. The researchers used tissue engineering to evaluate the possibility for creating kidneys for transplantation. They used pig kidneys, removing cells through a process called decellularization while preserving the organ's microarchitecture. The researchers then perfused pig kidney cells and human red blood cells to the empty kidney structure to recreate it. The methodologies used, showed promising results, suggesting a hopeful method to address the organ shortage. This proof-of-concept lays the foundation for potentially applying this technology to human kidneys, which could significantly improve outcomes for ESRD patients by providing more transplantable organs.