2016
DOI: 10.1002/pds.3860
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Evaluating different physician's prescribing preference based instrumental variables in two primary care databases: a study of inhaled long‐acting beta2‐agonist use and the risk of myocardial infarction

Abstract: Purpose Instrumental variable (IV) analysis with physician's prescribing preference (PPP) as IV is increasingly used in pharmacoepidemiology. However, it is unclear whether this IV performs consistently across databases. We aimed to evaluate the validity of different PPPs in a study of inhaled long-acting beta2-agonist (LABA) use and myocardial infarction (MI). Methods Information on adults with asthma and/or COPD and at least one prescription of beta2-agonist, or muscarinic antagonist was extracted from the C… Show more

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Cited by 12 publications
(7 citation statements)
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References 50 publications
(134 reference statements)
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“…Those instrumental variables and some others are presented in a more detailed form in [ 23 ], [ 24 , 25 ] or in [ 26 ] with enlightening discussion on their validity. In this work, we carry out a simulation study to examine how the proxy Z ∗ of physician’s preference performs in the context of logistic regression.…”
Section: Methodsmentioning
confidence: 99%
“…Those instrumental variables and some others are presented in a more detailed form in [ 23 ], [ 24 , 25 ] or in [ 26 ] with enlightening discussion on their validity. In this work, we carry out a simulation study to examine how the proxy Z ∗ of physician’s preference performs in the context of logistic regression.…”
Section: Methodsmentioning
confidence: 99%
“…A further study [34] also focuses on the strength of PPP IV but in a more specific way by defining boundaries for weak instruments (e.g., Pearson's correlation coefficient !0.15 or odds ratio (OR) !2). Also, the limitations of using IV methods including the weak instrument and limited sample size can be shown in a more specific way [35].…”
Section: Summary Of the Simulation Studiesmentioning
confidence: 99%
“…The latter approach is encouraged as the validity of PP IV can vary considerably by context. For example, the validity of PP IV have been found to vary by database and definition of PP [47,48], where the latter may also result in varying effect estimates [49]. Homogeneity (A4h) or monotonicity (A4m) should receive more attention in future studies given recent studies on how monotonicity in PP IVs can easily be violated [23,36,50].…”
Section: Areas Of Applicationmentioning
confidence: 99%