Evaluating drug interactions, adverse drug reactions, and level of  adherence to highly active antiretroviral therapy regimen amongst HIV-positive patients who referred to an AIDS healthcare center in Fars, southern Iran: the  first multifaceted study from Iran

Shafiekhani, Mojtaba; Karimi, Shahram; Davarpanah, Mohammad Ali; Vazin, Afsaneh

doi:10.5114/hivar.2017.65334

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…There are various results regarding the impact of sex on DDIs, as in some studies a higher percentage was seen in men[1011] and others it was the opposite. [4] The cause of this difference may be due to the study of sex factor on inpatients or outpatients or the average life expectancy being greater in women.…”

Section: Discussionmentioning

confidence: 99%

Impact of clinical pharmacist's interventions on potential drug–Drug interactions in the cardiac care units of two university hospitals in Shiraz, South of Iran

et al. 2019

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Objective:The main objective of this study aimed to assess drug–drug interactions (DDIs) in the cardiac care unit (CCU) and cardiac surgery units and the role of a clinical pharmacist in detecting and preventing the expected DDIs.Methods:This cross-sectional study was conducted in the CCU Units of Nemazee and Shahid Faghihi Hospitals, two referral hospitals in Shiraz, South of Iran, from August to February 2016. Patients older than 18 years, who were admitted and had received >24 h of inpatient services in these wards with two or more medication orders, were included in this study. All medication orders were evaluated by a pharmacist and DDIs were examined based on the Lexi-Interact™ software. In cases with serious DDIs (D or X), the physicians and nurses were informed, and intervention was conducted by a clinical pharmacist.Findings:A total of 3706 medical orders were evaluated. 6478 DDIs were detected, of which, 446 (6.88%) belonged to Classes D and X, and a total of 43.43% of all hospitalizations had at least one DDI. Factors with the most considerable influence on DDIs included an increased number of prescribed medications and patients underlying disease. The physicians accepted 62% of the interventions. The most frequent drugs responsible for interactions of Classes C, D, and X were aspirin, warfarin, and clopidogrel, respectively.Conclusion:This study shows that a significant number of clinical DDIs exist in hospitalized patients, especially among consumers of warfarin and aspirin. The role of a clinical pharmacist in preventing such interactions and safer pharmacotherapy management for hospitalized patients is essential.

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Section: Discussionmentioning

confidence: 99%

Impact of clinical pharmacist's interventions on potential drug–Drug interactions in the cardiac care units of two university hospitals in Shiraz, South of Iran

et al. 2019

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“…Shafiekhani 2017 48 63.5 Jiménez-Guerrero 2018 13 45. 5 Molas 2018 49 44.7 41.5 3.3 Ranzani 2018 14 53.1 47.4 5.7 Siefried 2018 50 45.4 Halloran 2019 51 49.9 López-Centeno 2020 19 18.3 3.2…”

Section: 4mentioning

confidence: 99%

Prevalence of Potentially Clinically Significant Drug–Drug Interactions With Antiretrovirals Against HIV Over Three Decades: A Systematic Review of the Literature

Hodge

Hodel

Hughes

et al. 2023

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Design, development, implementation, and evaluation of a severe drug–drug interaction alert system in the ICU: An analysis of acceptance and override rates

Karajizadeh,

Zand,

Vazin

et al. 2023

International Journal of Medical Informatics

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Evaluating drug interactions, adverse drug reactions, and level of adherence to highly active antiretroviral therapy regimen amongst HIV-positive patients who referred to an AIDS healthcare center in Fars, southern Iran: the first multifaceted study from Iran

Cited by 4 publications

References 30 publications

Impact of clinical pharmacist's interventions on potential drug–Drug interactions in the cardiac care units of two university hospitals in Shiraz, South of Iran

Impact of clinical pharmacist's interventions on potential drug–Drug interactions in the cardiac care units of two university hospitals in Shiraz, South of Iran

Prevalence of Potentially Clinically Significant Drug–Drug Interactions With Antiretrovirals Against HIV Over Three Decades: A Systematic Review of the Literature

Design, development, implementation, and evaluation of a severe drug–drug interaction alert system in the ICU: An analysis of acceptance and override rates

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