This study provides a comprehensive analysis of the financial performance of aquaculture firms in Portugal from 2013 to 2022, considering regional, age, and size dynamics. Using financial data from the ORBIS database, key performance indicators are calculated to assess the industry’s economic sustainability, regional disparities, and firm-level effects. The analysis reveals insights into the resilience of aquaculture firms in navigating economic challenges, such as the COVID-19 pandemic, and highlights the importance of tailored policy interventions to support regional development and industry competitiveness. Age trends show the influence of industry experience on financial performance, with older firms demonstrating higher turnover and profitability. Size trends indicate the advantages of economies of scale for larger firms, while smaller firms exhibit agility and innovation. This study contributes to the understanding of aquaculture economics in Portugal, providing valuable implications for policymakers, industry stakeholders, and aquaculture firms. By considering regional, age, and size dynamics, stakeholders can develop comprehensive strategies to enhance the sector’s long-term sustainability and resilience in an increasingly dynamic market environment. Recommendations are provided for policymakers to support regions with lower performance metrics, enhance infrastructure development, and promote workforce productivity to foster balanced economic growth across the aquaculture sector in Portugal.