Evaluating glioblastoma tumour sphere growth and migration in interaction with astrocytes using 3D collagen-hyaluronic acid hydrogels

Cui, Yixiao; Lee, Paul; Reardon, Joshua; Lynch, Samuel E.; Otero, José; Sizemore, Gina M.; Winter, Jessica O.

doi:10.1039/d3tb00066d

Cited by 6 publications

(1 citation statement)

References 80 publications

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“…In fact, if the glioma is minimally invasive (i.e., U87MG glioma cell line), astrocytes are able to totally block its migration and probably to stimulate a robust immune response. If the glioma is highly invasive (i.e., LN229 glioma cell line), astrocytes increase the migratory capacity of tumor cells by inducing over-expression of genes related to migratory signaling pathways, such as STAT3 (signal transducer and activator of transcription) and HGF/MET (hepatocyte growth factor/mesenchymal-epithelial transition factor) ( Cui et al, 2023 ).…”

Section: Brain Tumor/non-neoplastic Astrocyte Crosstalkmentioning

confidence: 99%

Non-neoplastic astrocytes: key players for brain tumor progression

Catalano,

Limatola,

Trettel

2024

Front. Cell. Neurosci.

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Astrocytes are highly plastic cells whose activity is essential to maintain the cerebral homeostasis, regulating synaptogenesis and synaptic transmission, vascular and metabolic functions, ions, neuro- and gliotransmitters concentrations. In pathological conditions, astrocytes may undergo transient or long-lasting molecular and functional changes that contribute to disease resolution or exacerbation. In recent years, many studies demonstrated that non-neoplastic astrocytes are key cells of the tumor microenvironment that contribute to the pathogenesis of glioblastoma, the most common primary malignant brain tumor and of secondary metastatic brain tumors. This Mini Review covers the recent development of research on non-neoplastic astrocytes as tumor-modulators. Their double-edged capability to promote cancer progression or to represent potential tools to counteract brain tumors will be discussed.

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Section: Brain Tumor/non-neoplastic Astrocyte Crosstalkmentioning

confidence: 99%

Non-neoplastic astrocytes: key players for brain tumor progression

Catalano,

Limatola,

Trettel

2024

Front. Cell. Neurosci.

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The Pattern of Copper Release in Copper‐Based Nanoparticles Regulates Tumor Proliferation and Invasiveness in 3D Culture Models

Garcia‐Peiro,

Guerrero‐López,

Hornos

et al. 2024

Small Science

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Cancer is a leading cause of death worldwide. Glioblastoma (GBM) is a major challenge in oncology due to its highly invasive nature and limited treatment options. GBM's aggressive migration beyond tumor margins and rapid tumor growth hinders success in patient treatment. Localized therapeutic delivery, such as the use of transition metals like copper, is highlighted as a novel therapeutic agent for many potential biomedical applications. Herein, it is aimed to study the effects of Cu release on the proliferation and invasiveness of cancer cells. To this end, novel copper‐based nanostructures with different release patterns are designed. Using a complex 3D cell culture model to mimic the tumor microenvironment, it is shown that different patterns of copper ion release have a strong impact on GBM progression and invasiveness. The findings highlight the importance of optimizing localized copper release patterns to tailor different tumor treatment strategies. They also show the potential and suitability of 3D microchips as instruments to study the behavior of tumor spheroids. In spite of their limitations, these 3D microdevices enable a controlled and close monitoring of the influence of environmental factors (such as the presence of Cu ions) on the proliferation and invasiveness of the cells, with a better approach to reality compared to 2D models and with a more controlled environment, compared to an in vivo model.

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Co-culture models for investigating cellular crosstalk in the glioma microenvironment

Niu,

Zhang,

Wang

2024

Cancer Pathogenesis and Therapy

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Evaluating glioblastoma tumour sphere growth and migration in interaction with astrocytes using 3D collagen-hyaluronic acid hydrogels

Abstract: Glioblastoma cells co-cultured with astrocytes in col-HA hydrogels exhibit changes in migration patterns. 3D in vitro models using ECM mimetic materials can be used to analyze glioma-astrocyte crosstalk.

Cited by 6 publications

References 80 publications

Non-neoplastic astrocytes: key players for brain tumor progression

Non-neoplastic astrocytes: key players for brain tumor progression

The Pattern of Copper Release in Copper‐Based Nanoparticles Regulates Tumor Proliferation and Invasiveness in 3D Culture Models

Co-culture models for investigating cellular crosstalk in the glioma microenvironment

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