Evaluating information loss in the National Cancer Database from cases lost to follow‐up

Cotler, Joseph; Nogueira, Letícia; McCabe, Ryan; Brajcich, Brian C.; Maduka, Richard C.; Lum, Sharon S.; Harris, James B.; Hawhee, Vicki; Mullett, Timothy W.; Bilimoria, Karl Y.; Palis, Bryan E.

doi:10.1002/jso.26977

Cited by 1 publication

(2 citation statements)

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“…Importantly, the NCDB represents one of the largest and most comprehensive cancer registries in the world, capturing more than 72% of all newly diagnosed cancer cases in the US annually 18 . Specific details regarding data abstraction by certified tumor registrars, data quality procedures, and variables collected within the NCDB have previously been described 16,19 . In addition, all data reported within the NCDB is completely deidentified, and thus, compliant with the Health Insurance Portability and Accountability Act and exempt from institutional review board review.…”

Section: Methodsmentioning

confidence: 99%

“…18 Specific details regarding data abstraction by certified tumor registrars, data quality procedures, and variables collected within the NCDB have previously been described. 16,19 In addition, all data reported within the NCDB is completely deidentified, and thus, compliant with the Health Insurance Portability and Accountability Act and exempt from institutional review board review.…”

Section: Data Sourcementioning

confidence: 99%

See 1 more Smart Citation

Utilization and survival outcomes of neoadjuvant chemotherapy for early‐stage gastric cancer

Janczewski,

Buchheit,

Jacobs

et al. 2024

Journal of Surgical Oncology

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Background and ObjectivesGiven increased utilization of neoadjuvant therapy (NAT) for gastric adenocarcinoma, practice patterns deviating from standard of care (upfront resection) remain unknown. We sought to identify factors associated with NAT use and survival outcomes among early‐stage gastric cancers.MethodsThe National Cancer Database identified patients with early‐stage (T1N0M0) gastric cancer (2010−2020). Multivariable logistic regression assessed characteristics associated with NAT utilization compared to upfront surgery. After 1:1 propensity score matching, Kaplan−Meier methods and Cox regression assessed overall survival (OS).ResultsOf 6452 patients with early‐stage gastric cancer, 626 (9.7%) received NAT. Patients who received NAT were more likely treated at community hospitals, had moderate to poorly differentiated disease, and tumors located in the cardia (all p < 0.05). After propensity score matching, 1,248 patients remained. Median OS for NAT was 37.1 months (IQR 20.2−64.0) versus 45.6 months (IQR 22.5−72.8) for resection (p < 0.001). Treatment with NAT remained independently predictive of worse OS on Cox regression (hazard ratio 1.19; 95% confidence interval 1.05−1.34).ConclusionsAlthough patients who received NAT had more aggressive prognostic features, NAT was associated with worse OS despite accounting for this selection bias. These results highlight the importance of adhering to guidelines, regardless of differing disease characteristics, which has significant implications on outcomes.

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Section: Methodsmentioning

confidence: 99%