Evaluating macro‐ and micronutrients and food groups intake with the risk of developing inflammatory bowel disease: Is there any association?

Farsi, Farnaz; Tahvilian, Negin; Heydarian, Azadeh; Karimi, Sara; Ebrahimi, Sara; Ebrahimi‐Daryani, Nasser; Tabataba-vakili, Sanam; Heshmati, Javad; Mokhtare, Marjan

doi:10.1002/fsn3.2988

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…We discovered a link between total dairy consumption and a lower risk of UC. Likewise, in another case–control study in Iran, researchers reported both high‐ and low‐fat dairy products to be marginally protective against UC (Farsi et al., 2022 ). In contrast to our observations, dairy product intake did not change odds of UC in another study in a small study examining dietary protein intakes and risk of UC (Rashvand et al., 2015 ).…”

Section: Discussionmentioning

confidence: 94%

Consumption of dairy products and odds of ulcerative colitis: An Iranian case–control study

Amini,

Khademi,

Salavatizadeh

et al. 2023

Food Science & Nutrition

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The association between dairy product consumption and the risk of ulcerative colitis (UC) is not well elucidated. This case–control study examined the association between Iranian adults' dairy consumption and UC risk. We used a valid food frequency questionnaire to analyze dietary intakes in 340 patients with pathologically confirmed cases of UC and 782 controls as part of a case–control research. Pasteurized milk, cheese, and yogurt dietary intakes were calculated along with dairy products. Other variables were acquired using questionnaires. Study participants' mean (± SD) age and body mass index were 41.5 ± 14.1 years and 27.4 ± 4.77 kg/m2, respectively. After adjusting for potential variables, individuals who consumed more total dairy products were less likely to get UC than those who consumed less (odds ratio [OR]: 0.44; 95% confidence interval (CI): 0.24, 0.79). We found a significant reverse association between milk intake (OR: 0.13; 95% CI: 0.07–0.24) and yogurt intake (OR: 0.52; 95% CI: 0.29–0.91) and UC, after controlling for potential confounders. Also, no significant association was found between cheese and UC risk (OR: 1.38; 95% CI: 0.84–2.28). Higher consumption of total dairy products may reduce UC risk. To be specific, milk and yogurt are inversely associated with this disorder. However, no link was found between cheese intake and UC. Longitudinal observational studies, especially cohorts, are needed to further assess these associations.

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Section: Discussionmentioning

confidence: 94%

Consumption of dairy products and odds of ulcerative colitis: An Iranian case–control study

Amini,

Khademi,

Salavatizadeh

et al. 2023

Food Science & Nutrition

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The association of ultra-processed food consumption with adult inflammatory bowel disease risk: a systematic review and dose-response meta-analysis of 4 035 694 participants

Babaei,

Pourmotabbed,

Talebi

et al. 2023

Nutrition Reviews

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Context There is an inconsistency between the results obtained from observational studies regarding intake of ultra-processed foods (UPFs) and the risk of inflammatory bowel disease (IBD). Objectives A dose-response meta-analysis was performed to evaluate the relationship between UPF intake and the risk of IBD. Data Sources Searches were performed in the PubMed, ISI Web of Science, and Scopus databases up to November 2, 2022. Data Extraction Data were available from 24 studies including a total of 4 035 694 participants from 20 countries. Data Analysis Risk ratios for IBD were analyzed by a random-effects model. Outcomes indicated that UPF intake was linked to an increased risk of IBD (relative risk [RR], 1.13; 95%CI, 1.06–1.21; P = 0.001; I2 = 73.2%; n = 59; N = 4 035 694). This association was significant, especially for the risk of Crohn’s disease (CD) (RR, 1.19; 95%CI, 1.00–1.41; I2 = 78.2%; P = 0.046; n = 23; N = 2 167 160), unlike the risk of ulcerative colitis (UC) (RR = 1.11; 95%CI, 0.99–1.26; P = 0.085; I2 = 60.3%; n = 27; N = 2 167 918). Also, results revealed that each 10% enhancement in daily UPF intake was not related to the risk of IBD (RR, 1.05; 95%CI, 0.98–1.14; P = 0.168; I2 = 31.9%; n = 4) or the risk of UC (RR, 1.01; 95%CI, 0.92–1.11; P = 0.876; I2 = 34.7%; n = 2) in adults. However, results suggested that for every 10% increase in daily UPF intake, there was a 19% increase in the risk of CD (RR, 1.19; 95%CI, 1.01–1.32; P = 0.021; I2 = 0.0%; n = 2) among adults. In addition, the results showed a positive linear relation between UPF intake with CD risk (Pnonlinearity = 0.431; Pdose response = 0.049) but not risk of IBD or UC. Conclusion High intake of UPFs was linked with an enhanced IBD risk, a specific risk of CD. However, conducting more observational studies among several ethnicities and using specific tools that accurately assess the amount of UPF consumption, components of UPFs, and food additives may be necessary. Systematic Review Registration: PROSPERO registration no. CRD42023390258.

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Dairy Consumption and Inflammatory Bowel Disease among Arab Adults: A Case–Control Study and Meta-Analysis

Almofarreh,

Sheerah,

Arafa

et al. 2024

Nutrients

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Background: Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a complex disease with increasing global incidence and prevalence. Although dairy consumption has been linked to various chronic diseases, its relationship with IBD remains uncertain. Additionally, there is a lack of data on this topic from Arab countries. This study aimed to investigate the association between dairy consumption and IBD through a case–control study among Arab populations, followed by a meta-analysis of available studies. Method: First, we used data from 158 UC patients, 244 CD patients, and 395 controls attending a polyclinic in Riyadh, Saudi Arabia. All participants were aged ≥ 18 years. Logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs) of UC and CD for individuals who reported the highest versus the lowest frequencies of dairy consumption. Next, we conducted a meta-analysis, combining our results with those from other eligible studies after searching several databases. We used the I2 statistics to examine statistical heterogeneity across studies and the regression test for funnel plot asymmetry to assess publication bias. Results: The case–control study showed a negative association between frequent dairy consumption and UC (OR (95% CI) = 0.64 (0.41, 1.00)) but not CD (OR (95% CI) = 0.97 (0.65, 1.45)). In the meta-analysis, the highest frequencies of dairy consumption were negatively associated with both UC and CD: ORs (95% CIs) = 0.82 (0.68, 0.98) and 0.72 (0.59, 0.87), respectively. A moderate heterogeneity across studies was noticed in the UC meta-analysis (I2 = 59.58%) and the CD meta-analysis (I2 = 41.16%). No publication bias was detected. Conclusions: Frequent dairy consumption could protect against the development of UC and CD, suggesting potential dietary recommendations in the context of IBD prevention.

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Evaluating macro‐ and micronutrients and food groups intake with the risk of developing inflammatory bowel disease: Is there any association?

Cited by 4 publications

References 41 publications

Consumption of dairy products and odds of ulcerative colitis: An Iranian case–control study

Consumption of dairy products and odds of ulcerative colitis: An Iranian case–control study

The association of ultra-processed food consumption with adult inflammatory bowel disease risk: a systematic review and dose-response meta-analysis of 4 035 694 participants

Dairy Consumption and Inflammatory Bowel Disease among Arab Adults: A Case–Control Study and Meta-Analysis

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