Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses
Sarah Buddle,
Leysa Forrest,
Naomi Akinsuyi
et al.
Abstract:Background Metagenomics is a powerful approach for the detection of unknown and novel pathogens. Workflows based on Illumina short-read sequencing are becoming established in diagnostic laboratories. However, barriers to broader take-up include the need for high sequencing depths, long turnaround times, and limited sensitivity. Newer metagenomics protocols based on Oxford Nanopore Technologies (ONT) sequencing allow acquisition and analysis of data in real time, potentially reducing the need for high-volume se… Show more
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