Evaluating plasma assisted noninvasive surgery (PANIS) as a new method for pterygium removal; a clinical case series

Abstract

Purpose: The present study aimed to evaluate the outcomes of a new technique for pterygium surgery using a plasma-based method. Methods: A clinical case series study was carried out in 6 patients. Six eyes with grade 2 or 3 of primary pterygium were operated. The pterygium head was detached from the corneal surface. Then, the free conjunctival edges were attached near the limbus using the plasma spots [generated by Plexr device (GMV, Rocca Priora, RM, Italy)]. Refractive Error (RE), Visual Acuity (VA), Intraocular Pressure (IOP), Contrast Sensitivity (CS), Corneal Fluorescein Staining (CFS), Tear Meniscus Height (TMH), High Order Aberrations (HOA), and Ocular Surface Disorder Index (OSDI) were measured before the operation, one week after the operation, as well asone, three, and six months post-surgery. Slit-lamp images were taken before surgery and six months after that. Results: No intraoperative and postoperative complications were observed. Mild degrees of pain, tearing, foreign body sensation, and irritation was reported during the first week after surgery. No significant change was found in IOP, CS, and TMH parameters during the 6-month follow-up. A slight improvement was measured in CFS and HOA after surgery. Compare to before surgery, RE, VA, and OSDI improved after pterygium removal. The follow-up examinations revealed pterygium recurrence in 2 eyes. Conclusion: Our results showed that plasma-assisted noninvasive surgery can provide a simple, fast, and effective techniquefor pterygium removal with no suture or glue. Although, considering the two observed recurrences in this study, we decided to modify the surgical method in the subsequent studies. Keywords: pterygium; treatment; plasma; noninvasive surgery; case series.

Evaluation of the Effect of Plasma Occlusion of Punctum (POP) on Dry Eye Disease Treatment: A 6-month Randomized Clinical Trial

“…In another research, Inflammatory cytokines in tear and serum has checked 4 times within 6 months follow-up after plasma spots on Rats conjunctiva, and this study also reported no persistent inflammatory responses [29]. After 3 animal studies, human ocular surface diseases have been targeted to treating with atmospheric low-temperature plasma and published case series studies, including conjunctivochalasis, conjunctival cyst, pinguecula, pterygium, punctal occlusion, conjunctival concretion, pseudophakic bullous keratopathy, conjunctival nevus [15,[30][31][32][33][34]. All these novel modalities have been taught to ophthalmologists all over the world, as a safe, office-based and effective approaches [35].…”

Innovative Solutions for Swift Enhancement: A Case Series on Filamentary keratitis treatment with Plasma Occlusion of Puncta

“…These safety evaluations confirmed the initiation of human trials to use plasma technology for treating ocular surface diseases such as conjunctival cyst, conjunctivochalasis, pinguecula, pseudophakic bullous keratopathy, conjunctival concretion, pterygium, dry eye disease, and conjunctival nevus. A published case series about the PANIS modality (plasma-assisted noninvasive surgery) with an average follow-up of 6 months proved the safety and efficacy of this novel technique for treating common ocular surface diseases [7,[25][26][27][28][29][30][31][32].…”

PANIS Method: A Cutting-Edge Approach for Lid Margin and Periocular Benign Lesions

“…The PANIS method has been used to treat ocular surface diseases such as conjunctivochalasis, conjunctival cysts, dry eye disease, pinguecula, conjunctival concretion, pseudophakic bullous keratopathy, pterygium, and conjunctival nevus [36][37][38][39][40][41][42][43][44][45][46].…”