Hot-spotting is a reliability problem influencing photovoltaic (PV) modules, where a mismatched solar cell/cells heat up significantly and reduce the output power of the affected PV module. Therefore, in this paper, a succinct comparison of seven different state-of-the-art MPPT techniques are demonstrated, doing useful comparisons with respect to amount of power extracted, hence calculate their tracking accuracy. The MPPT techniques have been embedded into a commercial off-the-shelf MPPT unit, accordingly running different experiments on multiple hot-spotted PV modules. Furthermore, the comparison includes real-time long-term data measurements over several days and months of validation. Evidently, it was found that both fast changing MPPT (FC-MPPT) and the modified beta (M-Beta) techniques are best to use with PV modules affected by hot-spotted solar cells as well as during partial shading conditions, on average, their tracking accuracy ranging from 92% to 94%. Ultimately, the minimum tracking accuracy is below 93% obtained for direct PWM voltage controller (D-PWM-VC) MPPT technique.