Evaluating prognostic significance of preoperative C-reactive protein to albumin ratio in older patients with pathological stage II or III colorectal cancer

Numata, Koji; Ono, Yukari; Ju, Mihwa; Onuma, Shizune; Tanaka, Ayano; Kawabe, Taiichi; Sawazaki, Sho; Higuchi, Akio; Yamanaka, Kazuki; Hatori, Shinsuke; Saeki, Hiroyuki; Matsukawa, Hiroshi; Rino, Yasushi; Tani, Kazuyuki

doi:10.3393/ac.2022.00367.0052

Cited by 6 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study showed that the CAR was affected by age and tumor factors, which is consistent with previous studies. 15 , 17 In addition, the time-dependent ROC curve for CAR was superior to those for other inflammation-based indices in most postoperative observation periods in patients aged ≥ 70 years. Systemic inflammatory response is associated with patients’ nutritional, functional, and immunological statuses, 27 and a high CAR has been reported to be a good predictor of poor survival outcomes in patients with CRC of various backgrounds, not only in older people.…”

Section: Discussionmentioning

confidence: 93%

“…Systemic inflammatory response is associated with patients’ nutritional, functional, and immunological statuses, 27 and a high CAR has been reported to be a good predictor of poor survival outcomes in patients with CRC of various backgrounds, not only in older people. 12 , 13 , 16 , 17 , 28 - 31 …”

Section: Discussionmentioning

confidence: 99%

“… 12 , 15 , 16 However, a few studies have reported the effect of CAR on the prognosis of older patients with CRC. 17 …”

mentioning

confidence: 99%

See 2 more Smart Citations

C-Reactive Protein/Albumin Ratio Is an Independent Risk Factor for Recurrence and Survival Following Curative Resection of Stage I–III Colorectal Cancer in Older Patients

Bekki,

Shimomura,

Hattori

et al. 2024

Ann Surg Oncol

View full text Add to dashboard Cite

Background The number of older patients with cancer has increased, and colorectal cancer is expected to be affected by this trend. This study aimed to compare prognostic factors, including nutritional and inflammation-based indices, between patients aged ≥ 70 and < 70 years following curative resection of stage I–III colorectal cancer. Patients and Methods This study included 560 patients with stage I–III colorectal cancer who underwent curative resection between May 2010 and June 2018. A retrospective analysis was performed to identify prognosis-associated variables in patients aged ≥ 70 and < 70 years. Results Preoperative low body mass index, high C-reactive protein/albumin ratio, and comorbidities were mainly associated with poor prognosis in patients aged ≥ 70 years. Tumor factors were associated with a poor prognosis in patients aged < 70 years. The C-reactive protein/albumin ratio was independently associated with poor overall survival and recurrence-free survival in those aged ≥ 70 years. The time-dependent area under the curve for the C-reactive protein/albumin ratio was superior to those of other nutritional and inflammation-based indices in most postoperative observation periods in patients aged ≥ 70 years. Conclusions Tumor factors were associated with a poor prognosis in patients aged < 70 years. In addition to lymph node metastasis, preoperative statuses were associated with poor prognosis in patients aged ≥ 70 years. Specifically, the preoperative C-reactive protein/albumin ratio was independently associated with long-term prognosis in patients aged ≥ 70 years with stage I–III colorectal cancer after curative resection.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

C-Reactive Protein/Albumin Ratio Is an Independent Risk Factor for Recurrence and Survival Following Curative Resection of Stage I–III Colorectal Cancer in Older Patients

Bekki,

Shimomura,

Hattori

et al. 2024

Ann Surg Oncol

View full text Add to dashboard Cite

show abstract

“…The association between chronic inflammation and cancer development and progression is well-established, encompassing cellular transformation, promotion, survival, proliferation, invasion, angiogenesis, and metastasis [ 4 6 ]. Notably, elevated circulating levels of CRP, indicative of inflammatory status, have been linked to poor prognoses in various cancers, including endometrial, liver, cervical, colorectal, breast, and non-small cell lung cancer [ 7 8 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of preoperative pan-immune-inflammation value on clinical and oncologic outcomes after colorectal cancer surgery: a retrospective study

Seo,

Kim,

Jeong

et al. 2024

Ann Surg Treat Res

View full text Add to dashboard Cite

Purpose Surgical resection, the primary treatment for colorectal cancer (CRC), is often linked with postoperative complications that adversely affect the overall survival rates (OS). The pan-immune-inflammation value (PIV), a novel biomarker, is promising in evaluating cancer prognoses. We aimed to explore the impact of preoperative immune inflammation status on postoperative and long-term oncological outcomes in patients with CRC. Methods A retrospective analysis of 203 patients with CRC who underwent surgery (January 2016–June 2020) was conducted. The preoperative PIV was calculated as [(neutrophil count + platelet count + monocyte count) / lymphocyte counts]. The PIV optimal cutoff value was determined based on the OS using the Contal and O’Quigley methods. Results A PIV value ≥155.90 was defined as high. Patients were categorized into low-PIV (n = 85) and high-PIV (n = 118) groups. Perioperative clinical outcomes (total operation time, time to gas out, sips of water, soft diet, and hospital stay) were not significantly different between the groups. The high-PIV group exhibited more postoperative complications (P = 0.024), and larger tumor size compared with the low-PIV group. Multivariate analysis identified that American Society of Anesthesiologists grade III (P = 0.046) and high-PIV (P = 0.049) were significantly associated with postoperative complications. The low-PIV group demonstrated higher OS (P = 0.001) and disease-free survival rates (DFS) (P = 0.021) compared with the high-PIV group. Advanced N stage (P = 0.005) and high-PIV levels (P = 0.047) were the identified independent prognostic factors for OS, whereas advanced N stage (P = 0.045) was an independent prognostic factor for DFS. Conclusion Elevated preoperative PIV was associated with an increased incidence of postoperative complications and served as an independent prognostic factor for OS.

show abstract

The association of blood biomarkers with treatment response and adverse health outcomes in older patients with solid tumors: A systematic review

Holstein

Berkmortel

Trompet

et al. 2023

Journal of Geriatric Oncology

View full text Add to dashboard Cite

Evaluating prognostic significance of preoperative C-reactive protein to albumin ratio in older patients with pathological stage II or III colorectal cancer

Cited by 6 publications

References 31 publications

C-Reactive Protein/Albumin Ratio Is an Independent Risk Factor for Recurrence and Survival Following Curative Resection of Stage I–III Colorectal Cancer in Older Patients

C-Reactive Protein/Albumin Ratio Is an Independent Risk Factor for Recurrence and Survival Following Curative Resection of Stage I–III Colorectal Cancer in Older Patients

Effect of preoperative pan-immune-inflammation value on clinical and oncologic outcomes after colorectal cancer surgery: a retrospective study

The association of blood biomarkers with treatment response and adverse health outcomes in older patients with solid tumors: A systematic review

Contact Info

Product

Resources

About