Evaluating Sarconesiopsis magellanica blowfly-derived larval therapy and comparing it to Lucilia sericata-derived therapy in an animal model

Díaz-Roa, Andrea; Gaona, María Antonia; Segura, Nidya Alexandra; Ramírez-Hernández, Alejandro; Cortés-Vecino, Jesús A.; Patarroyo, Manuel A.; Bello, Felio J.

doi:10.1016/j.actatropica.2015.10.024

Cited by 31 publications

(7 citation statements)

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“…Research has focused on the refinement of rearing techniques. For example, in recent years, noteworthy effort has been made in the testing of new fly species for MT in addition to the widely used L. sericata and L. cuprina (Dallavecchia et al ., ; Masiero et al ., ; Díaz‐Roa et al ., ), the development of artificial diets for both adult and larval flies (Tachibana & Numata, ; Zhang et al ., ), the development of efficacy assays for medicinal maggots (Blake et al ., ; Čičková et al ., ; Wilson et al ., ; Pickles & Pritchard, ), the potential for sterile rearing of flies from egg to adult (Gasz & Harvey, ), and the development of transgenic L. sericata to enhance MT wound healing properties (Linger et al ., ). However, although there is much information on the rearing of L. sericata and other calliphorid flies that comes from the forensic and other entomological literature, there is considerable variation in rearing set‐ups and conditions depending on the nature of the study, species of fly and field of research.…”

Section: Resultsmentioning

confidence: 99%

The maggot therapy supply chain: a review of the literature and practice

Stadler

2019

Medical Vet Entomology

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Maggot therapy (MT) is the clinical application of living fly larvae for the treatment of non‐healing wounds and wounds that require debridement. This systematized and expanded literature review is the first study to investigate MT through the conceptual and disciplinary framework of supply chain management. The review of 491 selected academic papers was expanded to include the grey literature and online information resources to construct a first‐pass theory of the medicinal maggot supply chain. It shows that the literature to date has focused on isolated discussions of echelon‐specific issues such as diet improvement and sterilization protocols in the production echelon, and the relative effectiveness of medicinal maggot application methods in the treatment echelon. There is little knowledge in the public domain regarding the transport and distribution of medicinal maggots, but existing supply chains for vaccines, blood and pathology specimens may provide learning and supply chain integration opportunities. Maggot therapy knowledge across the treatment echelon is generally substantive but there is still insufficient knowledge regarding patients' and health care providers' attitudes toward the therapy, and their experiences of receiving and administering MT. Moreover, there is no research concerned with the humane disposal of medicinal flies during production and after treatment.

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Section: Resultsmentioning

confidence: 99%

The maggot therapy supply chain: a review of the literature and practice

Stadler

2019

Medical Vet Entomology

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“…no se plantean diferencias significativas en el proceso de cicatrización de la lesión dependiendo de la especie de mosca usada: Lucilia sericata, L. illustris, L. caesar, L. cuprina, L. eximia, Phormia regina, Calliphora erythrocephala, C. vicina, Chrysomya rufifacies, Cynomyia cadaverina, Wohlfahrtia nuba, Musca domestica y Sarconesiopsis magellanica (Sherman y Pechter, 1988;Parnés y Lagan, 2007;Li et al, 2008;Sherman, 2009;González-de Paz et al, 2010;Wolff Echeverri et al 2010, Ríos et al, 2013Sherman et al, 2013;Díaz-Roa et al, 2016).…”

Section: Discussionunclassified

“…Los reportes sobre el tratamiento de úlceras leishmánicas no han señalado diferencias estadísticamente significativas en la aplicación de la TL, ni en los parámetros de cicatrización evaluados, luego de lograr la cicatrización de la úlceras aplicando larvas de L. sericata y S. magellanica en un modelo murino (Díaz-Roa et al, 2016). Sin embargo, los resultados de la TL con M. domestica mostrados en el presente estudio, podrían explicarse sobre la base de que esta especie de mosca no pertenece al grupo de las Calliphoridae y no es una especie necrófaga, en contraste con las especies utilizadas en investigaciones anteriores y señaladas en la literatura (Arrivillaga et al, 2008;Wolff Echeverri et al, 2010;Polat et al, 2012;Polat y Kutlubay, 2014;Cruz-Saavedra et al, 2016).…”

Section: Discussionunclassified

Terapia Larval con Musca Domestica en el Tratamiento de la úlcera Leishmánicaen un Modelo Murino

Parrado¹,

Arrivillaga-Henríquez

Oviedo

et al. 2020

Acta biol. Colomb.

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La leishmaniosis es una enfermedad con gran impacto en salud pública dado a las características de las lesiones tegumentarias. El tratamiento experimental con terapia larval (TL) ha mostrado su uso potencial para la cura de la leishmaniosis, sin embargo, se han utilizado especies de moscas para TL en heridas causadas por Leishmania que no son de fácil colecta y cultivo bajo condiciones de laboratorio como Lucilia sericata o Calliphora vicina. El objetivo del presente trabajo fue usar una especie de mosca de fácil colecta, y de alta fecundidad como la Musca domestica para aplicarlas en TL de úlceras leishmánicas. Se realizó un estudio cuali-cuantitativo, de tipo descriptivo, mediante un diseño experimental empleado un modelo animal (Mesocricetus auratus), infectado con Leishmania amazonensis para evaluar el efecto terapéutico de la TL y comparar los resultados con el tratamiento químico antimonial de la droga experimental “Ulamina”. Se evidencia cicatrización y cura de la úlcera leishmánica en el 66,66 % de los animales tratados con TL en aplicación simple y del 100 % en TL combinada con Ulamina. El uso combinado de TL+Ulamina, muestra un efecto potenciador de la cura clínica de las úlceras, pero con persistente inflamación. Se observó una efectividad óptima de la TL con M. domestica, sobre las úlceras, aunque no se evidenció un efecto sobre L. amazonensis dado a la presencia de amastigotes en los frotis y a los amplicones obtenidos de 480 bp desde las improntas de los animales.

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“…A previous case report indicated that acupuncture and moxibustion improved staphylococcal wound healing and resulted in full recovery with a partial withdrawal of antibiotics in a patient with a poor response to antibiotics, suggesting their complementary role in staphylococcal wound care [ 90 ]. Interestingly, larval therapy has been used as an alternative treatment for hard-to-heal chronic and infected wounds [ 91 ]. Some anti-MRSA factors have been identified in larval excretions/secretions [ 92 ].…”

Section: Topical Antibiotic-free Treatments Against Mrsamentioning

confidence: 99%

New Is Old, and Old Is New: Recent Advances in Antibiotic-Based, Antibiotic-Free and Ethnomedical Treatments against Methicillin-Resistant Staphylococcus aureus Wound Infections

Dou

Jiang

Xie

et al. 2016

IJMS

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Staphylococcus aureus is the most common pathogen of wound infections. Thus far, methicillin-resistant S. aureus (MRSA) has become the major causative agent in wound infections, especially for nosocomial infections. MRSA infections are seldom eradicated by routine antimicrobial therapies. More concerning, some strains have become resistant to the newest antibiotics of last resort. Furthermore, horizontal transfer of a polymyxin resistance gene, mcr-1, has been identified in Enterobacteriaceae, by which resistance to the last group of antibiotics will likely spread rapidly. The worst-case scenario, “a return to the pre-antibiotic era”, is likely in sight. A perpetual goal for antibiotic research is the discovery of an antibiotic that lacks resistance potential, such as the recent discovery of teixobactin. However, when considering the issue from an ecological and evolutionary standpoint, it is evident that it is insufficient to solve the antibiotic dilemma through the use of antibiotics themselves. In this review, we summarized recent advances in antibiotic-based, antibiotic-free and ethnomedical treatments against MRSA wound infections to identify new clues to solve the antibiotic dilemma. One potential solution is to use ethnomedical drugs topically. Some ethnomedical drugs have been demonstrated to be effective antimicrobials against MRSA. A decline in antibiotic resistance can therefore be expected, as has been demonstrated when antibiotic-free treatments were used to limit the use of antibiotics. It is also anticipated that these drugs will have low resistance potential, although there is only minimal evidence to support this claim to date. More clinical trials and animal tests should be conducted on this topic.

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Evaluating Sarconesiopsis magellanica blowfly-derived larval therapy and comparing it to Lucilia sericata-derived therapy in an animal model

Cited by 31 publications

References 48 publications

The maggot therapy supply chain: a review of the literature and practice

The maggot therapy supply chain: a review of the literature and practice

Terapia Larval con Musca Domestica en el Tratamiento de la úlcera Leishmánicaen un Modelo Murino

New Is Old, and Old Is New: Recent Advances in Antibiotic-Based, Antibiotic-Free and Ethnomedical Treatments against Methicillin-Resistant Staphylococcus aureus Wound Infections

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