Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus

Yousefi, Maryam; Mozafari, Nikoo; Hosseini, Mahshid; Gholamin, Sharareh; Razavi, Seyed Mostafa; Namazi, Mohammad Reza; Younespour, Shima

doi:10.1111/ijd.13199

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…The role of various cytokines such as leptin (Mozafari, Robati, & Younespour, ) and interleukins 4 (Tavakolpour & Tavakolpour, ), 35 (Tavakolpour et al, ), and 21 (Tavakolpour, ) as well as sex hormones (Yousefi et al, ) and vitamin D (Moravvej, Mozafari, & Younespour, ) in the pathogenesis of pemphigus have also been noted in previous studies .…”

Section: Discussionmentioning

confidence: 62%

The elevated level of osteopontin in patients with pemphigus vulgaris: A cytokine‐like protein with a therapeutic potential

Ketabi

Nasiri

Kheirodin

et al. 2019

Dermatologic Therapy

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Background Pemphigus vulgaris (PV) is a life‐threatening autoimmune disease with no certain treatment. Anticytokine therapy is being increasingly discussed in multiple autoimmune diseases. Osteopontin (OPN) is a glycoprotein produced by a variety of immune cells. Increased OPN serum levels have been reported in several autoimmune diseases, with targeting OPN considered as a promising therapy in these diseases. However, the role of OPN in PV has not been well studied so far. Objective To investigate whether OPN level is elevated in PV patients in the active stage of the disease and to examine its possible relationship with disease severity and anti‐desmoglein (anti‐Dsg) antibodies levels. Materials and Methods This study included 53 consecutive subjects affected by PV and 38 age‐ and sex‐matched healthy controls. Clinical characteristics and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) were assessed. Serum OPN levels (pg/mL) and anti‐Dsg antibodies were also measured. Results The serum OPN level of the patient group proved to be statistically higher than that of the control group (11.08 ± 5.24 vs 8.47 ± 5.68; p = .02). No significant relationship were detected between the serum OPN level and anti‐Dsg1 or anti‐Dsg3 antibodies (r = 0.1, p = .2 and r = 0.1, p = .4), respectively. In addition, no correlation was found between serum OPN levels and severity of PV as measured by ABSIS (r = 0.08 and p = .5). Conclusion The growth observed in OPN levels in pemphigus patients suggests the role of OPN in pemphigus pathogenesis, but there is a need for more extensive studies to show how OPN can be associated with the PV pathogenesis and whether OPN could be used as an important therapeutic target in pemphigus disease.

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Section: Discussionmentioning

confidence: 62%

The elevated level of osteopontin in patients with pemphigus vulgaris: A cytokine‐like protein with a therapeutic potential

Ketabi

Nasiri

Kheirodin

et al. 2019

Dermatologic Therapy

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“…No statistical difference was noted in between two groups (P>0.05). Yousefi et al 20 found mean serum prolactin level in male patient was 185.4mIU/L and in female patient was 197.5mIU/L. There was no statistical difference between the two groups.…”

Section: Resultsmentioning

confidence: 90%

Serum Prolactin Concentration in Patients with Pemphigus Vulgaris

Sayem,

Hoq,

Ahmed

et al. 2023

Mugda Med. Coll. J.

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Background: Pemphigus vulgaris (PV) is an autoimmune bullous disorder characterized clinically by blisters and erosions of the skin and/or mucous membranes. Serum prolactin plays a role in the pathogenesis of pemphigus vulgaris. Objective: The study aims to observe the serum prolactin concentration in patients with pemphigus vulgaris. Methods: This cross-sectional study was conducted at the Department of Dermatology & Venereology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, between May 2017 and April 2018. A total of 35 patients were included in the study. A consecutive type of sampling technique was used. The dermatological examination was done to ascertain the extent of involvement of the disease. Results: Among 35 patients, 31.4% belonged to 30-50 years age group, while 62.9% belonged to >50 years and 5.7% patients belonged to <30 years ae group. The mean age was found 42.7±11.8 years with ranged from 19-65 years. The majority of the patients (57.1%) were male, and 42.9% patients were female. It was observed that 30(85.7%) had vesicles, 25(71.4%) had bulla, 35(100%) had erosions and 6(17.1%) had other types of lesions. 28 patients (80.0%) had scalp, 32(91.4%) had extremity, 35(100.0%) had trunk and 31(88.6%) had mucous membrane as the sites of involvement. The mean duration of disease was 9.0±12.7 months with a range from 0.5 to 36 months. It was observed that 9 patients (25.7%) had hyperprolactinemia, while 26 patients (74.3%) had normal levels of prolactin. The mean serum prolactin level was found 28.7±16.7 ng/ml with a range from 1.64 to 51.04 ng/ml. Conclusion: Since serum prolactin plays a role in the pathogenesis of pemphigus vulgaris, it may offer a novel therapeutic target for treatment of PV. Thus, we may reduce morbidity and mortality rate in PV patients by modifying their serum prolactin levels. Mugda Med Coll J. 2023; 6(1): 20-24

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“…The decline in the concentration of DHEAS is a phenomenon accompanying many autoimmune disorders such assystemic lupus erythematosus (SLE), rheumatoid arthritis (RA), 9 and pemphigus disease. 10 Androgen deficiency especially DHEA and DHEAS have also been reported in many patients with FFA, suggesting a new growing concept of the low androgen level theory in the pathogenesis of FFA. 11 DHEA and DHEAS are the most abundant circulating steroid hormones in humans which have many regulatory effects on the immune system, fat metabolism, and even fibrous pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Our study revealed that serum levels of DHEAS and androstendion were significantly lower in FFA patients compared to controls. The decline in the concentration of DHEAS is a phenomenon accompanying many autoimmune disorders such assystemic lupus erythematosus (SLE), rheumatoid arthritis (RA), 9 and pemphigus disease 10 . Androgen deficiency especially DHEA and DHEAS have also been reported in many patients with FFA, suggesting a new growing concept of the low androgen level theory in the pathogenesis of FFA 11 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum level of sex hormones in women with frontal fibrosing alopecia in comparison to healthy controls

Nasiri

Dadkhahfar

Mansouri

et al. 2020

Dermatologic Therapy

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The pathogenesis of frontal fibrosing alopecia (FFA) is still unknown while hormonal factors have been postulated to play a role. There is scarce evidence with divergent results on the role of sex hormones in FFA. To evaluate the possible association between sex hormone levels and FFA, this study included 30 female cases of FFA and 34 healthy controls. Serum free testosterone, dehydroepiandrosterone sulfate (DHEAS), Luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17-OH progesterone, androstenedione, and prolactin levels were measured in all subjects. Median and interquartile ranges of DHEAS and androstenedione were 79.26 (52.91-195.50) and 1.41 (0.90-2.29) in patients and 152.34 (81.72-218.63) and 2.31 (1.54-2.84) in healthy controls, respectively. The serum levels of DHEAS and androstenedione were significantly lower in FFA patients in comparison with healthy controls (P-value = .038 and .012, respectively). There were no significant differences in serum levels of free testosterone, LH, FSH, 17-OH progesterone, and prolactin between the FFA group and the control group The lower serum levels of DHEAS and androstenedione in FFA patients compared to controls is supporting a new growing concept of the low androgen level theory in the pathogenesis FFA, while the exact mechanism, clinical significance, and also the potential therapeutic effects of these hormones in FFA remain to be determined in future studies. K E Y W O R D S dehydroepiandrosterone sulfate, frontal fibrosing alopecia, sex hormones 1 | INTRODUCTION Frontal fibrosing alopecia (FFA) is a form of primary lymphocytic cicatricial alopecia with a distinctive clinical pattern of the frontotemporal hairline recession and eyebrow loss. 1,2 FFA is considered a variant of lichen planopilaris (LPP) which like LPP the infundibulo isthmic (bulge) region of the hair follicles is attacked by T-lymphocytic dominant inflammatory infiltrates. 1 In FFA, preferentially vellus like hairs are involved and permanently replaced by a scar-like fibrous tissue. 1 Although autoimmune, genetic, environmental, and hormonal factors have been proposed, the etiopathogenesis of FFA remains to be elucidated. The role of hormonal factors in the disease pathogenesis has been postulated based on the high prevalence of FFA in postmenopausal women, the association with early menopause, and androgenic alopecia 2 in some patients and the response to 5α reductase inhibitors. 3 In a multicenter study on 355 cases, Vañó-Galván et al found a high rate of women with FFA is presenting with early menopause or having undergone hysterectomy. 2 Ranasinghe et al in a retrospective study of 168 patients with LPP found androgen deficiency to be prevalent in many patients with FFA subtype. 4 In a case-control study on hormonal Soheila Nasiri and Sahar Dadkhahfar contributed equally to this study.

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Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus

Cited by 9 publications

References 20 publications

The elevated level of osteopontin in patients with pemphigus vulgaris: A cytokine‐like protein with a therapeutic potential

The elevated level of osteopontin in patients with pemphigus vulgaris: A cytokine‐like protein with a therapeutic potential

Serum Prolactin Concentration in Patients with Pemphigus Vulgaris

Evaluation of serum level of sex hormones in women with frontal fibrosing alopecia in comparison to healthy controls

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