2023
DOI: 10.1021/acsomega.3c06111
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Evaluating the Antischistosomal Activity of Dehydrodieugenol B and Its Methyl Ether Isolated from Nectandra leucantha─A Preclinical Study against Schistosoma mansoni Infection

Vinicius C. Rocha,
Rayssa A. Cajas,
Allan I. Andrade-de-Siqueira
et al.

Abstract: Schistosomiasis, a parasitic disease affecting nearly 250 million individuals globally, poses a significant health challenge. With praziquantel being the sole available treatment and its limited efficacy in early stage infections, the identification of novel bioactive compounds becomes imperative. This study examines the potential of dehydrodieugenol B (1) and its methyl ether (2), derived from the leaves of the Brazilian Nectandra leucantha plant (Lauraceae), in combatting Schistosoma mansoni infections throu… Show more

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Cited by 6 publications
(2 citation statements)
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“…Concentration–response curves were generated using nonlinear regression in GraphPad Prism software 8.0, with EC 50 values and respective 95% confidence intervals estimated as described previously. 40 , 41 …”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Concentration–response curves were generated using nonlinear regression in GraphPad Prism software 8.0, with EC 50 values and respective 95% confidence intervals estimated as described previously. 40 , 41 …”
Section: Methodsmentioning
confidence: 99%
“…The larvae were analyzed using a fluorescence inverted biological microscope INV100-FL (BEL Engineering). Concentration–response curves were generated using nonlinear regression in GraphPad Prism software 8.0, with EC 50 values and respective 95% confidence intervals estimated as described previously. , …”
Section: Methodsmentioning
confidence: 99%