Evaluating the association between household air pollution and oral cancer

Raj, A Thirumal; Patil, Shankargouda; Sarode, Sachin C.; Sarode, Gargi S; Rajkumar, Chandini

doi:10.1016/j.oraloncology.2017.11.012

Cited by 10 publications

(7 citation statements)

References 6 publications

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“…Moreover, alternative etiological factors, such as drug consumption (23), household air pollution (24), occupation (25), have been proposed to explain oral cancer not related to tobacco/alcohol habits, but require validation in large prospective cohorts of patients. In contrast, some factors, such as the regular consumption of fruits and vegetables could play a role in reducing oral cancer risk (26).…”

Section: Extrinsic Risk Factorsmentioning

confidence: 99%

Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients

et al. 2020

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In some western countries, an increasing incidence of oral squamous cell carcinoma (OSCC) has been observed in non-smoker non-drinker patients (NSND), mostly in women with HPV-negative OSCC. In the context of the unknown etiology and mechanisms of tumorigenesis of OSCC in NSND, we discuss data supporting the hypothesis of a viral origin not related to HPV. OSCC from NSND are characterized by an antiviral DNA methylation and gene expression signature. Based on the similar increasing incidence of oral tongue SCC (OTSCC) and oropharyngeal SCC (OPSCC) in young women and men respectively, we hypothesize that changes in sexual behaviors may lead to an increasing incidence of herpesvirus in the oral cavity, especially HSV-2, similarly to what has already been described in HPV-positive OPSCC. Because viral genome integration has not been detected in OSCC from NSND, a "hit and run" viral mechanism involving epigenome deregulation could therefore play a key role at early steps of oral carcinogenesis in this population of patients. In conclusion, epidemiological, clinical and molecular data supports a "hit and run" viral origin of OSCC from NSND.

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Section: Extrinsic Risk Factorsmentioning

confidence: 99%

Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients

et al. 2020

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“…Except for age and sex, commonly recognized etiologic factors for oral carcinoma include smoking, drinking, 2 HPV 3 and betel quid consumption 4 . In addition to those traditional risk factors, other putative environmental exposure risks have been reported in recent studies 5,6 . Among those, trace elements have attracted interest.…”

Section: Introductionmentioning

confidence: 99%

Association between serum arsenic and oral cancer risk: A case‐control study in southeast China

Chen

Qiu

Cai

et al. 2021

Comm Dent Oral Epid

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Objectives Evidence on serum arsenic and oral cancer risk was limited. We aimed to evaluate the association between serum arsenic and the risk of oral cancer in a southeast China population. Methods Serum arsenic was determined for 325 oral cancer patients and 648 controls using inductively coupled plasma‐mass spectrometry (ICP‐MS). Logistic regression and restricted cubic spline were analysed the association between serum arsenic level and oral cancer risk, and crude and adjusted odds ratios (aOR) with 95% confidence interval (95% CI) were calculated. Factors adjusted for included age, gender, BMI, smoking, drinking, education, residence, marital status and dietary factors. Stratification analysis was further performed according to drinking, smoking and dietary characteristics. Results Serum arsenic level was lower in the case group (P50 = 19.2μg/L, IQR = 11.6 ~ 26.4μg/L) than in the control group (P50 = 30.2 μg/L, IQR = 25.0 ~ 36.4 μg/L). An inverse but nonlinear association was observed between arsenic level and oral cancer risk by restricted cubic spline. These with moderate serum arsenic levels had a lower risk of oral cancer than those with low levels (OR = 0.11; 95%CI: 0.07‐0.18), after adjusting for demographic and dietary intake factors. We also kept serum arsenic as a continuous variable in a regression model, where a similar inverse association between arsenic and oral cancer was observed, with OR = 0.86 (95%CI: 0.84‐0.88). Stratification analysis revealed no significant multiplicative interactions between serum arsenic and smoking, drinking or dietary intake. Conclusion Serum arsenic is inversely related to oral cancer risk. Relative to those with low levels of arsenic, people with moderate serum arsenic levels had a lower risk of oral cancer. If confirmed, serum arsenic level may be a useful predictive marker for oral cancer risk.

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“…Cases of OSCC presenting with no history of known risk factors have often been attributed to these potential risk factors ranging from environmental factors such as household air pollution to infections, immune status, genetic profile, etc. ( 9 - 15 ). Among this much importance is being given to microbial agents as they have shown to possess the carcinogenic potential (presence of oncogenes) and have shown to have a causal association with other forms of carcinoma including HPV with cervical and oropharyngeal cancer and EBV with nasopharyngeal cancer ( 35 - 38 ).…”

Section: Discussionmentioning

confidence: 99%

“…Unlike tobacco, and alcohol the causal nature of potential risk factors including environmental agents (e.g., household air pollution), infections (e.g., HPV, EBV, candida); immune status, etc. to oral cancer remains controversial ( 9 - 15 ). Studies have shown contrasting results which in turn is largely attributed to the variations in the sensitivity and specificity of the diagnostic tools used.…”

Section: Introductionmentioning

confidence: 99%

Assessing the potential association between Epstein-Barr virus and oral squamous cell carcinoma: a systematic review and meta- analysis

Sivakumar¹,

Gupta²,

Rosdy³

et al. 2020

Transl Cancer Res TCR

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Background This study aims to qualitatively and quantitatively review the association between Epstein-Barr virus (EBV) and oral squamous cell carcinoma (OSCC). Methods PubMed, Scopus, and Web of Science databases were searched using the keywords “EBV or Epstein Barr virus and Oral cancer or Oral squamous cell carcinoma” for published case-control studies in the English language upto August 2019. Results The search yielded 985 articles out of which 966 articles were excluded by screening their titles and abstracts as they were irrelevant or duplicates. Based on the full-text assessment of the remaining 19 articles, only 7 satisfied the inclusion criteria and were included in the qualitative analysis, out of which only 4 were compatible to be included in the meta-analysis. The diagnostic modalities used included immunohistochemistry, in situ hybridization and polymerase chain reaction. The diagnostic targets included latent membrane protein (LMP)-1, EBV determined nuclear antigen-1, EBV-encoded small non-polyadenylated RNA-2. The meta-analysis showed that there is an association between the EBV and OSCC. Conclusions Determining the association of EBV with OSCC is highly tedious due to the contrasting data obtained from individuals’ studies which in turn is due to the wide variations in the sensitivity and specificity of the diagnostic modalities used and diagnostic targets selected. Although the meta-analysis revealed an association between EBV and OSCC, the number and the quality of the studies included in the meta-analysis are limited, thus the association requires further validation for any conclusive inference.

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Evaluating the association between household air pollution and oral cancer

Cited by 10 publications

References 6 publications

Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients

Arguments to Support a Viral Origin of Oral Squamous Cell Carcinoma in Non-Smoker and Non-Drinker Patients

Association between serum arsenic and oral cancer risk: A case‐control study in southeast China

Assessing the potential association between Epstein-Barr virus and oral squamous cell carcinoma: a systematic review and meta- analysis

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