Sustainable building involves reducing negative environmental impacts with a simultaneous increase in life quality. The aim is to optimize building performances while considering all aspects of sustainability: environmental, economic, and social. The building structure determines the building’s performances, and it should be designed and evaluated as a subsystem of the building, in line with the objectives of the system–building. This paper investigates structural design based on integrated design objectives within the criterion of social benefits for users throughout the use phase of the building, focusing on protection and safety, aspects of comfort, spatial organization, spatial adaptability, and maintenance. The problem was studied using integrative literature review methodology and system theory. The main findings of the research are a review and critical analysis of the representative literature and the derived conceptual framework for structural design based on the criterion of social benefits for building users, which should support more comprehensive and more efficient decision-making during systemic design and optimization of buildings. The presented integrated literature review indicates the need for the application of a systemic approach to structural design in order to create sustainable buildings.