Evaluating the Effect of a Novel Molluscicide in the Endemic Schistosomiasis Japonica Area of China

Xia, Jing; Yuan, Yong; Xu, Xingjian; Wei, Feili; Liu, Guiling; Liu, Min; Li, Jianqiang; Chen, Rujuan; Zhou, Zhengping; Nie, Shaoping

doi:10.3390/ijerph111010406

Cited by 26 publications

(20 citation statements)

References 17 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hubei has been an endemic hotspot for schistosomiasis, which may be related to its lake and marshland regions [ 42 ] and other biological and social factors that facilitate the transmission of S. japonicum [ 43 ]. In the present study, we found that Hubei accounted for >50 % of all human S. japonicum infections in China during 2009–2014, which indicates that better control strategies and measures are needed in Hubei.…”

Section: Discussionmentioning

confidence: 99%

A spatial analysis of human Schistosoma japonicum infections in Hubei, China, during 2009–2014

Zhu

Cai

et al. 2016

Parasites Vectors

Self Cite

View full text Add to dashboard Cite

BackgroundThe province of Hubei is located in the middle of China, near the middle and lower reaches of the River Yangtze, and is an area where schistosomiasis is endemic. It is challenging to control this disease in this environment, and it would be useful to identify clusters of infection and transmission, as well as their distributions during recent years. Therefore, this study aimed to analyze the spatial distribution of schistosomiasis in Hubei, in order to facilitate the effective control and elimination of this disease.MethodsWe collected schistosomiasis surveillance data from all endemic counties in Hubei during 2009–2014. A geographical information system (ArcGIS, version 10.1) was used to link the counties’ geographical data with the epidemiological data, and the spatial scanning method (FleXScan v3.1.2) was used to identify spatial clusters of human infections with Schistosoma japonicum.ResultsIn Hubei, patients who exhibited stool test results that were positive for S. japonicum accounted for > 50 % of all cases in China during 2009–2014. However, each endemic county in Hubei exhibited a declining trend in the number of human S. japonicum infections during the study period. The ArcGIS analyses revealed that the middle reaches of the River Yangtze were highly endemic for S. japonicum infections. Spatial scan analyses revealed the following infection clusters: two clusters in ten counties during 2009, two clusters in nine counties during 2010, three clusters in 12 counties during 2011, two clusters in 12 counties during both 2012 and 2013 and two clusters in ten counties during 2014. Most of the cluster regions were located in the lake and marshland regions along the basins of the River Yangtze.ConclusionWe successfully identified schistosomiasis clusters at the county level in Hubei during 2009–2014, and our results revealed that the clusters were typically located in lake and marshland regions. These data may be useful for controlling and eliminating schistosomiasis in other high-risk areas.

show abstract

Section: Discussionmentioning

confidence: 99%

A spatial analysis of human Schistosoma japonicum infections in Hubei, China, during 2009–2014

Zhu

Cai

et al. 2016

Parasites Vectors

Self Cite

View full text Add to dashboard Cite

show abstract

“…In China, some molluscicides have also been reported as effective and less toxic, such as the suspension concentrate of niclosamide [ 50 ]. A promising study was conducted by Xia et al [ 51 ] using a novel molluscicide derivative from niclosamide, named LDS (salt of quinoid-2′, 5-dichloro-4′-nitrosalicylanilide). To assess the effects of large-scale field applications of LDS, tests were done in 15 counties in the endemic S. japonica areas of Hubei province, China.…”

Section: Introductionmentioning

confidence: 99%

“…To assess the effects of large-scale field applications of LDS, tests were done in 15 counties in the endemic S. japonica areas of Hubei province, China. However, despite showing good results of mollusc mortality, these studies also need to clarify its impact on the environment [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

Critical analysis of molluscicide application in schistosomiasis control programs in Brazil

Coelho

Caldeira

2016

Infect Dis Poverty

View full text Add to dashboard Cite

In Brazil, Biomphalaria glabrata, B. tenagophila, and B. straminea are naturally infected by the trematode Schistosoma mansoni, the causative agent of schistosomiasis. Despite decades of governmental efforts through official control programs, schistosomiasis remains an important public health problem in the country: thousands of people are infected with the trematode each year and millions live in endemic areas. The World Health Organization recommends using a combination of molluscicide (niclosamide) and mass chemotherapy to control the transmission of schistosomiasis, with this treatment successfully reducing the morbidity of the disease. In the past, niclosamide has been used in official schistosomiasis control programs in Brazil. However, as B. glabrata recolonizes even after molluscicide application, the use of molluscicides has gradually decreased in the country until they were discontinued in 2002, mainly due to the rising global pressure to preserve the environment and the difficulties of obtaining licenses from the Brazilian Ministry of Environment to use toxic substances in aquatic ecosystems. Therefore, the discovery of new molluscicides, which could be more selective to Biomphalaria species and less harmful to the aquatic ecosystem, is necessary. In addition, political efforts to sensitize funders to provide grants for this field of research are required. In this context, this article aims to make a critical analysis of molluscicide application in schistosomiasis control programs in Brazil.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-016-0153-6) contains supplementary material, which is available to authorized users.

show abstract

“…Niclosamide was selected as a molluscicide in the 1950s after screening of well over 20,000 compounds for toxicity against the schistosome-transmitting snail Biomphalaria glabrata [ 7 ]. Currently, Bayluscide, containing niclosamide or its ethanolamine salt, is still being applied in many endemic areas, mostly in Africa and Asia [ 8 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide

et al. 2015

View full text Add to dashboard Cite

In view of the call by the World Health Organization (WHO) for elimination of schistosomiasis as a public health problem by 2025, use of molluscicides in snail control to supplement chemotherapy–based control efforts is likely to increase in the coming years. The mechanisms of action of niclosamide, the active ingredient in the most widely used molluscicides, remain largely unknown. A better understanding of its toxicology at the molecular level will both improve our knowledge of snail biology and may offer valuable insights into the development of better chemical control methods for snails. We used a recently developed Biomphalaria glabrata oligonucleotide microarray (31K features) to investigate the effect of sublethal exposure to niclosamide on the transcriptional responses of the snail B. glabrata relative to untreated snails. Most of the genes highly upregulated following exposure of snails to niclosamide are involved in biotransformation of xenobiotics, including genes encoding cytochrome P450s (CYP), glutathione S-transferases (GST), and drug transporters, notably multi-drug resistance protein (efflux transporter) and solute linked carrier (influx transporter). Niclosamide also induced stress responses. Specifically, six heat shock protein (HSP) genes from three super-families (HSP20, HSP40 and HSP70) were upregulated. Genes encoding ADP-ribosylation factor (ARF), cAMP response element-binding protein (CREB) and coatomer, all of which are involved in vesicle trafficking in the Golgi of mammalian cells, were also upregulated. Lastly, a hemoglobin gene was downregulated, suggesting niclosamide may affect oxygen transport. Our results show that snails mount substantial responses to sublethal concentrations of niclosamide, at least some of which appear to be protective. The topic of how niclosamide’s lethality at higher concentrations is determined requires further study. Given that niclosamide has also been used as an anthelmintic drug for decades and has been found to have activity against several types of cancer, our findings may be of relevance in understanding how both parasites and neoplastic cells respond to this compound.

show abstract

Evaluating the Effect of a Novel Molluscicide in the Endemic Schistosomiasis Japonica Area of China

Cited by 26 publications

References 17 publications

A spatial analysis of human Schistosoma japonicum infections in Hubei, China, during 2009–2014

A spatial analysis of human Schistosoma japonicum infections in Hubei, China, during 2009–2014

Critical analysis of molluscicide application in schistosomiasis control programs in Brazil

Altered Gene Expression in the Schistosome-Transmitting Snail Biomphalaria glabrata following Exposure to Niclosamide, the Active Ingredient in the Widely Used Molluscicide Bayluscide

Contact Info

Product

Resources

About