Evaluating the effect of piceatannol in cardiac hypertrophy in human stem-cell-derived cardiomyocytes

Falconer, Kerry; Zhelev, Nikolai

doi:10.7750/biodiscovery.2015.16.2

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“…Differentiated cells derived from pluripotent cells are very valuable in modern research as a model system for the mechanisms of cell proliferation, migration, differentiation, cell-cell and cell-matrix interactions, cellular senescence and death under physiological and pathological conditions, and they have high potential for future clinical applications (Trifonov et al 2013, Falconer and Zhelev 2015. Nevertheless, to date very few cell products derived by differentiation of pluripotent cells have been used in any type of officially approved treatment or a clinical trial, mainly because of the inherent risk for induction of cancer growth in the recipient, originating from trace amounts of undifferentiated cells in the cell product (Schwartz et al 2015, Schulz 2015.…”

Section: The Role Of Irc In the Establishment Maintenance Of Pluripomentioning

confidence: 99%

The success of stem cell transplantations and the potential post-transplantation complications may be dependent, among other factors, on the capacity of the recipient and the transplanted cells to repair DNA damage

Reynolds¹

2016

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Cell therapy is presently a treatment of choice for many types of haematological and metabolic diseases and is likely to become a therapeutic option for other severe human diseases and conditions in the near future. The success of cell transplantation depends on a variety of factors, including the degree of HLA match between the donor and the recipient, the infectious burden of the graft, cell dosage, age, general state of the recipient and other incompletely characterised features of the donor and the recipient. It is likely that the individual capacity for identification and repair of DNA damage and maintenance of genomic integrity may account, at least in part, for these elusive factors that modulate transplantation outcome in terms of success rate and both long and short term posttransplantation complications. This paper outlines the role of individual repair capacity of the donor and recipient in cell transplantations, summarising the little knowledge already accumulated in the field whilst analysing the known major issues of the use of different types of stem cells. Attention will be given to their capacity to maintain the integrity of their genome, the ability to renew their own population, differentiate into various cell types and in ‡

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Section: The Role Of Irc In the Establishment Maintenance Of Pluripomentioning

confidence: 99%

The success of stem cell transplantations and the potential post-transplantation complications may be dependent, among other factors, on the capacity of the recipient and the transplanted cells to repair DNA damage

Reynolds¹

2016

View full text Add to dashboard Cite

show abstract

Evaluating the effect of piceatannol in cardiac hypertrophy in human stem-cell-derived cardiomyocytes

Cited by 1 publication

References 0 publications

The success of stem cell transplantations and the potential post-transplantation complications may be dependent, among other factors, on the capacity of the recipient and the transplanted cells to repair DNA damage

The success of stem cell transplantations and the potential post-transplantation complications may be dependent, among other factors, on the capacity of the recipient and the transplanted cells to repair DNA damage

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