Evaluating the Effect of Utrogestan on Idiopathic Intrauterine Growth Retardation

Mohammadi, Belgheis; Matinfar, Marzieh; Yaagoub, Driss; Shabanian, Sheida

doi:10.4103/abr.abr_27_20

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Endocrine regulation of normal human fetal growth involves interactions between the mother, the placenta, and the fetus. (1,2) Furthermore, one of the main causes of intrauterine growth restriction (IUGR) is a disrupted interaction between the three components, some of the risk factors for IUGR related to the mother include advanced maternal age, nutritional status during pregnancy, genetics, and health status before pregnancy (3,4) Some of the fetal causes of IUGR are aneuploidy, congenital malformations, fetal infection, and genetics, among others. (4) Mother and fetus are physiologically interrelated by the placenta, the essential organ that regulates the exchange of nutrients and gases and the removal of cell detritus in this binomial.…”

Section: Introductionmentioning

confidence: 99%

Interspecies pregnancy between Ovis canadensis mexicana and Ovis aries with reduced placental P450scc expression and intrauterine growth restriction

García,

Cabrera-Reyes,

Molina-Salinas

et al. 2024

Vet Mex OA

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The present study aimed to assess the steroidogenic process in the placenta of hybrids Ovis canadensis mexicana × Ovis aries, particularly, to determine the plasma lipid profile and the relative abundance of proteins related to the steroidogenesis, to elucidate in part the mechanism of progesterone deficiency in hybrids. Plasma lipoproteins and placental cholesterol were determined by dry chemical colorimetric assays. Steroidogenic acute regulatory protein (STARD1), StAR-related lipid transfer domain protein 3 (STARD3), cholesterol side-chain cleavage enzyme (P450ssc), and 3β-hydroxysteroid dehydrogenase (3β-HSD) were evaluated by Western blot. In addition, STARD3 was also investigated by immunohistochemical experiments in sheep placenta. Results indicated that cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL) plasma levels were similar between hybrid and control pregnancy groups. Conversely, intracellular cholesterol was increased (P ˂ 0.05) in the placenta tissue of hybrids. No significant differences in the relative abundance of both STARD3, STARD1, and 3β-HSD enzyme were observed in the placenta of hybrids compared to control animals, while the relative abundance of cytochrome P450scc was lower in hybrids than in control animals (P = 0.0279). The presence of STARD3 was observed in the cytoplasmic and perinuclear regions of mononucleate and binucleate cells of the trophoblast in the sheep placenta. The significant decrease in the abundance of P450scc in hybrids’ placenta may explain the decrease in progesterone biosynthesis, which has been related to intrauterine growth restriction (IUGR) in these animals previously.

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