Evaluating the effectiveness of the influenza vaccine during respiratory outbreaks in Singapore’s long term care facilities, 2017

Ng, Yixiang; Nandar, Khine; Chua, Lily Ai Vee; Mak, Tze Minn; Foo, Kelly; Muhammad, Imran Roshan; Low, Constance; Ma, Stefan; Ooi, Steven Peng-Lim; Lin, Raymond Tzer Pin; James, Lyn; Lee, Vernon Jian Ming

doi:10.1016/j.vaccine.2019.03.054

Cited by 13 publications

(17 citation statements)

References 16 publications

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“…37 Further studies should be conducted to determine the optimal vaccination schedule in countries with yearround influenza activity, especially when there is growing evidence of waning vaccine effectiveness. 38 The estimated proportion of P&I hospitalisations attributable to influenza was the highest for the youngest age group but, in contrast, was the lowest for the oldest age group. These results suggested that while both the young and the elderly were more prone to influenza-attributed hospitalisations, 10,11,39 older people were also particularly at risk of developing severe symptoms, and requiring hospitalisations, from other pathogens.…”

Section: Discussionmentioning

confidence: 96%

“…This shows that we may also have to vaccinate during the middle of the year, in addition to the recommendation by a WHO study to vaccinate in October . Further studies should be conducted to determine the optimal vaccination schedule in countries with year‐round influenza activity, especially when there is growing evidence of waning vaccine effectiveness …”

Section: Discussionmentioning

confidence: 99%

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Estimates of influenza‐associated hospitalisations in tropical Singapore, 2010‐2017: Higher burden estimated in more recent years

Chua

et al. 2019

Influenza Resp Viruses

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Background We previously estimated Singapore's influenza‐associated hospitalisation rate for pneumonia and influenza (P&I) in 2010‐2012 to be 29.6 per 100 000 person‐years, which corresponds to 11.2% of all P&I hospitalisations. Objectives This study aims to update Singapore's estimates of the influenza‐associated pneumonia and influenza (P&I) hospitalisation burden using the latest data from 2010 to 2017. Methods We estimated the number of P&I hospitalisations associated with influenza using generalised additive models. We specified the weekly number of admissions for P&I and the weekly influenza positivity in the models, along with potential confounders such as weekly respiratory syncytial virus (RSV) positivity and meteorological data. Results In 2010‐2017, 16.3% of all P&I hospitalisations in Singapore were estimated to be attributed to influenza, corresponding to an excess influenza‐associated P&I hospitalisation rate of 50.1 per 100 000 person‐years. Higher excess rates were estimated for children aged 0‐4 years (186.8 per 100 000 person‐years) and elderly aged ≥ 65 years (338.0 per 100 000 person‐years). Higher influenza‐associated hospitalisation rates were estimated for 2016 and 2017 (67.9 and 75.1 per 100 000 persons, respectively) years when the influenza A(H3N2) subtype was dominant. Conclusion Influenza burden in Singapore has increased since 2010. Influenza vaccination programmes should continue to be prioritised for the young and the elderly.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Estimates of influenza‐associated hospitalisations in tropical Singapore, 2010‐2017: Higher burden estimated in more recent years

Chua

et al. 2019

Influenza Resp Viruses

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“…45 A TND study conducted in long-term care facilities in Singapore reported an adjusted VE of 59.3% (95% CI: 18.0-79.8%) against all influenza in the 15-180 days post-vaccination, but no significant VE for 181-365 days after vaccination. 46 While no randomized clinical trials have directly addressed how protection changes with time following vaccination, waning efficacy was reported from a clinical trial of a liveattenuated influenza vaccination in children conducted in Asia, and of inactivated influenza vaccine and LAIV in healthy adults (aged 18-49 years). 47,48 Taken together, the results of these studies suggest that to maximize VE influenza vaccination should be administered as close as possible to season onset.…”

Section: Duration Of Clinical Protectionmentioning

confidence: 99%

“… 45 A TND study conducted in long-term care facilities in Singapore reported an adjusted VE of 59.3% (95% CI: 18.0–79.8%) against all influenza in the 15–180 days post-vaccination, but no significant VE for 181–365 days after vaccination. 46 …”

Section: Influenza Vaccination Strategies In Asiamentioning

confidence: 99%

“…NS = not significant, *p ≤ 0.05. Day 21–42 (Seroconversion) Day 180 Day 360 No Study Type IIV3 Comparator IIV3 Comparator IIV3 Comparator High dose influenza vaccine (Fluzone HD) 1 Nace, 2011–12 46 A/H1 27.4 78.2* 28.3 59.7 - - A/H3 10.2 26.2* 9.4 22.3* - - B 14.3 25.6* 15.4 22.9 - - 2 a Nace, 2012-13 46 A/H1 50 45.6 51.8 46.8 - - A/H3 14.2 23.4* 13.4 24.7* - - B 17.4 26.0* 18.9 25.3 - …”

Section: Influenza Vaccination Strategies In Asiamentioning

confidence: 99%

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Influenza in temperate and tropical Asia: a review of epidemiology and vaccinology

Young

Chen

2020

Human Vaccines & Immunotherapeutics

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The impact of seasonal influenza has been under-appreciated in Asia and surveillance data lags in most other regions. The variety of influenza circulation patterns in Asialargely due to the range of climateshas also only recently been recognized and its effect on the burden of disease is not fully understood. Recent reports that clinical protection wanes in the weeks after influenza vaccination emphasize the importance of optimally timing vaccination to local epidemiology. It also raises questions as to whether influenza vaccines should be administered more frequently than annually and what may be the benefits in Asia of access to new vaccines with enhanced immunogenicity and effectiveness. This review will summarize influenza surveillance data from Asian countries over 2011-2018, and consider the implications for vaccination strategies in different parts of Asia.

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Cold chain transportation decision in the vaccine supply chain

Zhao

Lev

2020

European Journal of Operational Research

122

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Evaluating the effectiveness of the influenza vaccine during respiratory outbreaks in Singapore’s long term care facilities, 2017

Cited by 13 publications

References 16 publications

Estimates of influenza‐associated hospitalisations in tropical Singapore, 2010‐2017: Higher burden estimated in more recent years

Estimates of influenza‐associated hospitalisations in tropical Singapore, 2010‐2017: Higher burden estimated in more recent years

Influenza in temperate and tropical Asia: a review of epidemiology and vaccinology

Cold chain transportation decision in the vaccine supply chain

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