Maxim GarifullinGE Healthcare 540 W Northwest Hwy, Barrington, IL 60010, USA Wait or queuing time is a principal performance measure for many discrete-event simulation (DES) models in healthcare. However, variation in wait time is often caused by both occupied downstream servers (e.g., beds) and organizational and human transition processes. DES models that attribute wait solely to occupied servers, ignoring transition process variability, face challenges in adequate baseline validation. Embedding regression models for survival data in DES to estimate patient wait times is a method capable of integrating the effects of transition processes with queuing. Developing these models as a sUb-component is further valuable in understanding the socio-technical system factors that drive pro longed waits. These general methods are exhibited in a DES for a large urban hospital with a primary output of wait time in the emergency department (ED) for transfer to an inpatient bed (boarding time). Simulated boarding time is compared before and after accounting for transition processes using survival analysis. 1 978-1-4673-9743-8/15/$31.00 ©2015 IEEE