Evaluating the effects of ivacaftor exposure on Staphylococcus aureus small colony variant development and antibiotic tolerance
Gretchen E Bollar,
Kendall M Shaffer,
Johnathan D Keith
et al.
Abstract:Background
Ivacaftor exhibits anti-staphylococcal properties but does not clear Staphylococcus aureus from the lungs of people with cystic fibrosis (pwCF). We assessed whether exposure to therapeutic concentrations of ivacaftor could allow S. aureus to form small colony variants (SCVs), a phenotype commonly associated with bacterial persistence.
Methods
Humanized G551D-CFTR (hG551D) rats were treated with ivacaftor for 7 days… Show more
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