Evaluating the Effects of Methanolic Leaf Extract of Neem Plant and Hog Plum on the Liver Histology of Zidovudine Induced-Oxidative Stress Wistar Rats

Ubah, Chidera; Asuquo, Olaitan R.; Oko, Gregory Elayeche; Ewaa, O. I.; Eluwa, Mokutima A.

doi:10.9734/jocamr/2018/46306

JOCAMR

2019

DOI: 10.9734/jocamr/2018/46306

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Evaluating the Effects of Methanolic Leaf Extract of Neem Plant and Hog Plum on the Liver Histology of Zidovudine Induced-Oxidative Stress Wistar Rats

Chidera Ubah

Olaitan R. Asuquo

Gregory Elayeche Oko

et al.

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2024

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Protective Effects of Plum on Liver and Gut Injury in Metabolic Dysfunction-Associated Fatty Liver Disease

Kim,

Hong,

Kim

et al. 2024

Nutrients

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Metabolic dysfunction-associated fatty liver disease (MASLD), a persistent liver condition associated with metabolic syndrome, is primarily caused by excessive fructose intake and a typical Western diet. Because there is currently only one approved treatment, lifestyle and dietary interventions are crucial. This study assessed the effects of dietary intervention involving freeze-dried plum (FDP), a natural source of antioxidants containing diverse polyphenols. This study aimed to assess its potential as a protective agent against the gut–liver axis and its therapeutic effects on liver injury and gut permeability issues associated with MASLD. We indicate that 10% FDP intake restored gut barrier proteins and reduced serum endotoxin levels in the MASLD mouse models. Additionally, 10% FDP intake significantly reduced hepatic oxidative stress, lipid metabolism, and fibrosis marker levels. Interestingly, FDP intake significantly reduced the levels of inflammatory cytokine tumor necrosis factor-α and markers of liver damage, such as serum alanine aminotransferase/aspartate aminotransferase and hepatic triglycerides. These results highlight that dietary intervention with FDP that acts as a natural antioxidant may be a significant protective and therapeutic agent against liver and gut damage caused by MASLD.

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Protective Effects of Plum on Liver and Gut Injury in Metabolic Dysfunction-Associated Fatty Liver Disease

Kim,

Hong,

Kim

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

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Evaluating the Effects of Methanolic Leaf Extract of Neem Plant and Hog Plum on the Liver Histology of Zidovudine Induced-Oxidative Stress Wistar Rats

Cited by 1 publication

References 9 publications

Protective Effects of Plum on Liver and Gut Injury in Metabolic Dysfunction-Associated Fatty Liver Disease

Protective Effects of Plum on Liver and Gut Injury in Metabolic Dysfunction-Associated Fatty Liver Disease

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