Evaluating the efficacy and safety of antidepressants in patients with bipolar disorder

Cheniaux, Elie; Nardi, Antônio Egídio

doi:10.1080/14740338.2019.1651291

Cited by 13 publications

(5 citation statements)

References 135 publications

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“…This may be due to prevasive residual symptoms ( 44 ) and/or clinicians’ beliefs and patients’ anticipatory anxiety regarding medication cessation ( 28 ). However, they have been associated with a wide range of adverse features in BD, including manic symptoms and rapid cycling for antidepressants ( 45 ) and cognitive impairment and addictive disorders for benzodiazepines ( 23 ). Additionally, both the possible causes and consequences of prescribing antidepressants and/or benzodiazepines in BD have been associated with SUD comorbidity in BD ( 46 , 47 ), further warranting the focus on these medication classes as proposed in the current study.…”

Section: Methodsmentioning

confidence: 99%

Preventive Medication Patterns in Bipolar Disorder and Their Relationship With Comorbid Substance Use Disorders in a Cross-National Observational Study

et al. 2022

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ObjectiveThe potential role of sub-optimal pharmacological treatment in the poorer outcomes observed in bipolar disorder (BD) with vs. without comorbid substance use disorders (SUDs) is not known. Thus, we investigated whether patients with BD and comorbid SUD had different medication regimens than those with BD alone, in samples from France and Norway, focusing on compliance to international guidelines.MethodsSeven hundred and seventy patients from France and Norway with reliably ascertained BD I or II (68% BD-I) were included. Medication information was obtained from patients and hospital records, and preventive treatment was categorized according to compliance to guidelines. We used Bayesian and regression analyses to investigate associations between SUD comorbidity and medication. In the Norwegian subsample, we also investigated association with lack of medication.ResultsComorbid SUDs were as follows: current tobacco smoking, 26%, alcohol use disorder (AUD), 16%; cannabis use disorder (CUD), 10%; other SUDs, 5%. Compliance to guidelines for preventive medication was lacking in 8%, partial in 44%, and complete in 48% of the sample. Compliance to guidelines was not different in BD with and without SUD comorbidity, as was supported by Bayesian analyses (highest Bayes Factor = 0.16). Cross national differences in treatment regimens led us to conduct country-specific adjusted regression analyses, showing that (1) CUD was associated with increased antipsychotics use in France (OR = 2.4, 95% CI = 1.4–3.9, p = 0.001), (2) current tobacco smoking was associated with increased anti-epileptics use in Norway (OR = 4.4, 95% CI = 1.9–11, p < 0.001), and (3) AUD was associated with decreased likelihood of being medicated in Norway (OR = 1.2, 95% CI = 1.04–1.3, p = 0.038).ConclusionSUD comorbidity in BD was overall not associated with different pharmacological treatment in our sample, and not related to the level of compliance to guidelines. We found country-specific associations between comorbid SUDs and specific medications that warrant further studies.

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Section: Methodsmentioning

confidence: 99%

Preventive Medication Patterns in Bipolar Disorder and Their Relationship With Comorbid Substance Use Disorders in a Cross-National Observational Study

et al. 2022

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“…The landscape of psychiatric pharmacotherapy has evolved over time, witnessing a surge in the number of approved drugs and the introduction of novel classes into clinical practice [28][29][30][31]. This trend is particularly notable in the treatment of depression and schizophrenia, where the absence of universally safe and effective drugs persists [32][33][34][35][36]. Additionally, off-label utilization of antidepressants and antipsychotics has been observed among patients with dementia and other neuro-cognitive disorders [37][38][39][40][41], contributing to an upward trajectory in psychiatric drug consumption [42,43].…”

Section: Research Context and Objectivesmentioning

confidence: 99%

Neuroleptic malignant syndrome and serotonin syndrome: a comparative bibliometric analysis

Sweileh

2024

Orphanet J Rare Dis

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Objective This study aimed to analyze and map scientific literature on Neuroleptic Malignant Syndrome (NMS) and Serotonin Syndrome (SS) from prestigious, internationally indexed journals. The objective was to identify key topics, impactful articles, prominent journals, research output, growth patterns, hotspots, and leading countries in the field, providing valuable insights for scholars, medical students, and international funding agencies. Methods A systematic search strategy was implemented in the PubMed MeSH database using specific keywords for NMS and SS. The search was conducted in the Scopus database, renowned for its extensive coverage of scholarly publications. Inclusion criteria comprised articles published from 1950 to December 31st, 2022, restricted to journal research and review articles written in English. Data were analyzed using Microsoft Excel for descriptive analysis, and VOSviewer was employed for bibliometric mapping. Results The search yielded 1150 articles on NMS and 587 on SS, with the majority being case reports. Growth patterns revealed a surge in NMS research between 1981 and 1991, while SS research increased notably between 1993 and 1997. Active countries and journals differed between NMS and SS, with psychiatry journals predominating for NMS and pharmacology/toxicology journals for SS. Authorship analysis indicated higher multi-authored articles for NMS. Top impactful articles focused on review articles and pathogenic mechanisms. Research hotspots included antipsychotics and catatonia for NMS, while SS highlighted drug interactions and specific medications like linezolid and tramadol. Conclusions NMS and SS represent rare but life-threatening conditions, requiring detailed clinical and scientific understanding. Differential diagnosis and management necessitate caution in prescribing medications affecting central serotonin or dopamine systems, with awareness of potential drug interactions. International diagnostic tools and genetic screening tests may aid in safe diagnosis and prevention. Reporting rare cases and utilizing bibliometric analysis enhance knowledge dissemination and research exploration in the field of rare drug-induced medical conditions.

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“…Some improve signi cantly, while others, especially those with concomitant manic symptoms, have had previous episodes of treatment-emergent mania or are rapid cyclers, exhibit manic switches or cycle acceleration [12]. The one of methods in avoidance switch was use of mood stabilizer,especially lithium carbonate [3,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

“…However, these medications should be used only in the short term because prolonged use is associated with an increased risk of treatmentemergent mania or hypomania [10].It had been found switch rate of bipolar depression had very higher than that in "nuipolar"depression [11].Patients with bipolar depression present very heterogeneous responses to the use of ADs. Some improve signi cantly, while others, especially those with concomitant manic symptoms, have had previous episodes of treatment-emergent mania or are rapid cyclers, exhibit manic switches or cycle acceleration [12]. The one of methods in avoidance switch was use of mood stabilizer,especially lithium carbonate [3,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

How About Effect of Lithium Carbonate on Preventive Switch Induced by Antidepressants in Patients With Depressive Episode? Chinese Data Analysis

Lv¹,

Tao

Sun

et al. 2021

Preprint

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Background: Although mania or hypomania was defined as indispensable for bipolar disorder, depressive episodes are more common and impairing, with proven response to treatments.So the prevention switch was a important affair in clinical psychiatryMethods: We searched CBM, CNKI, WANFANG and CSSCI in Chinese to find literature from July 1 2000 to July 31 2020 related to the study in model of “comparison of switch rate between combination treatment of lithium and antidepressant and monotherapy of antidepressant in patients with depressive episode”, among which results such as comments, letters, reviews and case reports were excluded. The rate of switch between groups was synthesized and discussed. Result: A total of 695 subjects were included in 9 studies. Random effect model is used to account for the data by Revman 5.2. The results showed that the switch rate of lithium carbonate was 8.28%(29/350),switch rate of antidepressant was 25.29%(87/344), which was very different in switch rate(OR=0.25, 95% CI: 0.16–0.39) and also indicated that lithium reduced switch rate was 67.25%(25.29%-8.28%/25.29%). In bipolar depression group, lithium reduced switch rate was 68.11%(25.84%-8.24%/25.84%). In depression group, lithium reduced switch rate was 67.34%(25.29%-8.26%/25.29%). In group of patients treated by SSRI, lithium reduced switch rate was 60.3%(29.85%-11.85%/29.85%).In group of patients treated by TCA, lithium reduced switch rate was 73.14%(22.28%-6.01%/22.28%). Conclusion: As typical mood stabilizer, lithium carbonate can reduced switch rate related to antidepressant in patients with depressive episode.

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Evaluating the efficacy and safety of antidepressants in patients with bipolar disorder

Cited by 13 publications

References 135 publications

Preventive Medication Patterns in Bipolar Disorder and Their Relationship With Comorbid Substance Use Disorders in a Cross-National Observational Study

Preventive Medication Patterns in Bipolar Disorder and Their Relationship With Comorbid Substance Use Disorders in a Cross-National Observational Study

Neuroleptic malignant syndrome and serotonin syndrome: a comparative bibliometric analysis

How About Effect of Lithium Carbonate on Preventive Switch Induced by Antidepressants in Patients With Depressive Episode? Chinese Data Analysis

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