Evaluating the efficacy of Etoricoxib in reducing post-operative pain associated with minor oral surgery. A randomized clinical trial

AL-MUKHTAR, Yusra Hameed; DELEME, Zaid Hazim; KHUDHUR, Ahmed Salih

doi:10.4322/bds.2023.e3854

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…The study showed no statistically significant difference in either group after patients were administered drugs 30 minutes before the procedure. The study suggested that etoricoxib can be used as a preemptive medication to reduce pain [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Nationwide Etoricoxib Injection Clinical Experience (NICE): Real-World Evidence in Indian Patients

Shetty,

Neema,

Muthu

et al. 2024

Cureus

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Introduction Pain is a major health issue globally. Etoricoxib, a highly selective COX-2 inhibitor, given orally, has been found to be efficacious and safe in the management of acute and chronic pain. Oral etoricoxib has been extensively studied; however, there is a lack of research exploring the use of etoricoxib via alternative routes, specifically intramuscular (IM) injection. This study aimed to evaluate the effectiveness and safety of an innovative and novel formulation of IM etoricoxib injection 90 mg/mL in the management of patients with acute pain in India. Method This was a real-world, multicenter, retrospective, observational study to investigate the effectiveness and safety of IM etoricoxib injection in the management of patients with acute pain in India (outpatient setting). The clinical data of 383 patients from 42 centers across India were collected from November 2022 to April 2023. Following approval from the site investigator, comprehensive patient-level information encompassing demographic and clinical variables as well as comorbidities was collected and entered into a case report form. Approval from the Independent Ethics Committee (IEC) and Institutional Review Board (IRB) was sought. The safety and effectiveness at 30 minutes and 60 minutes of IM etoricoxib injection were then analyzed. Results Among the studied patients, etoricoxib was used for the management of knee arthritis, fracture, post-traumatic pain, postoperative cases, acute back pain, back injury, torn ligament, and muscle strain and sprain. Of 383 patients, 98.17% had moderate-to-severe pain at baseline on the visual analogue scale (VAS) (0 being no pain and 10 being severe unbearable pain). The percentage of patients with severe pain reduced to only 6.78% and 4.17% at 30 minutes and 60 minutes, respectively. The improvement in the VAS score was statistically significant from baseline to 30 minutes and 60 minutes, and at 60 minutes compared to 30 minutes (p < 0.0001). More than half the patients (56.91%) had no pain at the site of the injection. Most of the doctors (70.23%) opined that the IM etoricoxib injection was better than their currently used NSAID injections for pain relief. Only 12.79% of patients required rescue analgesia post-IM etoricoxib injection. IM etoricoxib injection was well tolerated as 98.69% of the patients did not experience or report any adverse events post-IM injection. Conclusion This real-world, multicenter, retrospective, observational study across India demonstrated that the innovative and novel formulation of etoricoxib (90 mg/mL IM injection) was effective and well-tolerated in the management of acute pain. Overall, this study provides valuable insights into the real-world effectiveness and safety of IM etoricoxib injections, suggesting it could be a promising therapy for the management of acute pain for optimal patient benefit.

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Section: Introductionmentioning

confidence: 99%

Nationwide Etoricoxib Injection Clinical Experience (NICE): Real-World Evidence in Indian Patients

Shetty,

Neema,

Muthu

et al. 2024

Cureus

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Anesthetic effect of lidocaine injection for maxillary teeth with or without tetracaine gel as topical agent during dental extraction in sensitive patients

H Al-Mukhtar,

Hamid,

H Deleme

2024

Edorium J Dent

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Aims: Anxiety and fear from dental injections are common and particularly tense features in dental treatment. The direct sense of pain during the injection technique contributes significantly to this dread. The aim of the study was to assess the anesthetic effectiveness and pain of injectable buffered lidocaine with epinephrine with topical tetracaine gel (1%, 1.5%, and 2%) and placebo gel before injection. Methods: A randomized clinical trial was conducted patients attending the integrated clinics of the dentistry at Mosul University who needed dental surgical treatment. A total of 96 adult patients participated in the study, including 51 males and 45 females. Participants were randomly allocated into four groups, 24 for each one. The injection site was dried with gauze and approximately 0.2 mL of topical anesthetic agent with different concentrations utilized, then after 2 minutes’ local anesthesia, lidocaine with adrenaline with needle gauge 27 was applied for maxillary premolars and molars for infiltration technique and using pain scores as a parameter to assess pain and anxiety sensation. Therefore, the study involves 4 groups. Group A 1%, group B 1.5%, group C 2% tetracaine gel, and group D placebo (ultrasonic gel) as the control group, the data collected and analyzed. Results: From 96 participants (53.13% male and 46.87% female), there was a highly statistically significant difference between groups regarding pain sensation at time of injection, especially group C with 2% concentration of tetracaine in comparison with other groups. Conclusion: Topical anesthetics considerably lessened injection and needle insertion pain as compared to the placebo group, also topical anesthesia has a significant psychological impact on patients’ attitudes toward dental treatment, with most patients demanding topical anesthesia before dental injections in order to reduce their level of anxiety and fear toward dental injections.

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Evaluating the efficacy of Etoricoxib in reducing post-operative pain associated with minor oral surgery. A randomized clinical trial

Cited by 2 publications

References 27 publications

Nationwide Etoricoxib Injection Clinical Experience (NICE): Real-World Evidence in Indian Patients

Nationwide Etoricoxib Injection Clinical Experience (NICE): Real-World Evidence in Indian Patients

Anesthetic effect of lidocaine injection for maxillary teeth with or without tetracaine gel as topical agent during dental extraction in sensitive patients

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