Evaluating the HLA-G (rs1063320) genetic variant and risk of human papillomavirus infection: a meta-analysis of 953 cases and 877 controls

Moossavi, Maryam; Shojaee, Majid; Mousavi, Mahdieh; Alaei, Maryam; Mohammadoo‐Khorasani, Milad

doi:10.1080/01443615.2021.1965103

Cited by 1 publication

(2 citation statements)

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“…More studies are needed to decipher the pathways associated with cervix infections and cervical cancer. A recent meta‐analysis by Moossavi et al 53 has investigated HLA‐G +3142 C/G genetic variant and the risk of human papillomavirus infection, but they did not found any significant association. However, more studies still needed to confirm this finding since cancer is a multifactorial disease, and persistent viral infections would increase considerably cancer susceptibility and/or progression.…”

Section: Discussionmentioning

confidence: 94%

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The relationship of 3′UTR HLA‐G14‐bp insertion/deletion and +3142 C/G polymorphisms and soluble HLA‐G expression with gynecological cancers: An updated meta‐analysis

Tizaoui

Jalouli

Boujelbène

et al. 2022

Immunity Inflam & Disease

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Objectives Human leukocyte antigen‐G (HLA‐G) is implicated in several cancers and is considered to be an immune checkpoint regulator. We determined the association between polymorphisms in the 3′ untranslated region of HLA‐G and soluble HLA‐G (sHLA‐G) expression with gynecological cancers (GCs). Methods A meta‐analysis was conducted to examine the association between HLA‐G14‐bp insertion ( I )/ deletion ( D ) and +3142C/G polymorphism in GC and to evaluate sHLA‐G expression Results We revealed a significant association between the +3142C/G polymorphism and invasive cervical cancer (ICC) based on the allelic model G versus C (odds ratio [OR] = 0.738, 95% confidence interval [CI] = 0.563–0.966, p = 0.027), dominant GG+GC versus CC (OR = 0.584, 95% CI = 0.395–0.862, p = 0.007), and codominant GG versus CC (OR = 0.527, 95% CI = 0.312–0.891, p = 0.017) models, suggesting that the G allele and GG genotype are protective against ICC. In gynecological precancerous patients with human papillomavirus (HPV) infection, we found that the 14‐bp I/D under the codominant DD versus DI model (OR = 0.492, 95% CI = 0.241–1.004, p = 0.051) was of borderline significance. Soluble HLA‐G levels were significantly higher in patients compared with healthy controls (standardized mean differences [SMD] = 1.434, 95% CI = 0.442–2.526, p = 0.005). Stratification by cancer type revealed that the sHLA‐G levels were significantly increased in cervical cancer (SMD = 4.889, 95% CI = 0.468–9.310, p = 0.030) and in subjects of Asian ethnicity (SMD = 4.889, 95% CI = 0.467–9.309, p = 0.030). Conclusions HLA‐G14‐bp I/D and +3142 C/G polymorphisms are associated with GC and HPV‐associated cervical cancer. In addition, we found significantly increased sHLA‐G levels in cancer patients. These results provide a basis for further studies in diagnostics and immunotherapy of GC.

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Section: Discussionmentioning

confidence: 94%

“…More studies are needed to decipher the pathways associated with cervix infections and cervical cancer. A recent meta-analysis by Moossavi et al 53 has investigated HLA-G +3142 C/G genetic variant and the risk of human papillomavirus infection, but they did not found any significant association.…”

Section: Odds Ratio Heterogeneitymentioning

confidence: 94%