Evaluating the Impact of a Pharmacist-Led Antiretroviral Stewardship Program on Reducing Drug Interactions in HIV-Infected Patients

Billedo, Julie Anne S.; Berkowitz, Leonard; Cha, Agnes

doi:10.1177/2325957415600700

Cited by 21 publications

(20 citation statements)

References 9 publications

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“…A majority (91.7%) of the pharmacist interventions for the problems identified during the study were accepted by the physicians (23). Billedo et al showed that the clinical pharmacist's participation in the Antiretroviral Stewardship Program contributed to a reduction of drug-related errors and improvement of drug safety in patients (24). Evaluation of patients' treatments and recommendations to physicians and patients during ART by pharmacists have been reported by numerous studies in literature (10,22,25).…”

Section: Discussionmentioning

confidence: 92%

Polypharmacy and drug-related problems among people living with HIV/AIDS: a single center experience

Kara¹,

İnkaya²,

Haklı³

et al. 2019

Turk J Med Sci

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Background/aim: The HIV-infected population is aging, and the concomitant comorbidities increase the likelihood of polypharmacy. There is a scarcity of data for determining drug-related problems in people living with HIV/AIDS (PLWHA). Materials and methods: This cross-sectional study was carried out between September 1, 2015, and July 1, 2016. All patients underwent a face-to-face interview with a clinical pharmacist. The 'PCNE Classification V 7.0.' was used classify incident drug-related problems (DRPs). Results: The mean age of the patients was 40.4±13.06 years. The rate of polypharmacy was 66.1% in patients with comorbidities and 12.3% in those without comorbidities (p<0.001). DRPs were more prominent in older patients (46 vs. 37 years, p<0.001), with longer duration of antiretroviral therapy (ART) (45 vs. 27 months, p=0.014), and with lower education level (p=0.013). Receiving >3 ART drugs was associated with more DRPs in the logistic regression model (odds ratio: 8.299, 95% confidence interval: 1.924–35.803). Fifty-eight interventions were performed in 45 (24.9%) patients. Clinical pharmacist interventions were performed in 18.9% of patients without polypharmacy and in 38.9% of patients with polypharmacy (p<0.001). Conclusion: DRPs and polypharmacy are common among elderly PLWHA. More interventions are warranted to boost the quality of life in aging PLWHA. Keywords: human immunodeficiency virus, polypharmacy, drug-related problems

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Section: Discussionmentioning

confidence: 92%

Polypharmacy and drug-related problems among people living with HIV/AIDS: a single center experience

Kara¹,

İnkaya²,

Haklı³

et al. 2019

Turk J Med Sci

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“… 1 Pharmacist interventions in patients infected with HIV can contribute to the maintenance of antiretroviral therapy and improvement in clinical outcomes. 2 Partial adherence or non-adherence to ART is one of the main barriers to its effectiveness. 3 , 4 In this context, studies that identify the benefits of different pharmaceutical care practices in supporting adherence to antiretroviral therapy are necessary.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of a Pharmaceutical Care Model on Adherence to Antiretroviral Therapy: A SAME-Based Cohort Study in Brazil

Gerenutti¹,

Martinez²,

Bergamaschi³

2017

Adv Pharm Bull

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Purpose: To verify the effectiveness of a pharmaceutical care model developed by the Specialized Municipal Assistance Service in Sorocaba, Brazil, on adherence to ART among patients infected with HIV.Methods: A cohort study compared adherence to ART in two groups of patients: intervention group (patients assisted with pharmaceutical care, n=130) and non-intervention group (patients attended by the habitual dispensing process, n=229). Antiretroviral adherence was measured by the number of pharmacy refill records in a six-month period. The relationship between the use of other drugs for the treatment of opportunistic infections and the adherence rate in the intervention group and the correlation between adherence and viral load and CD4 lymphocytes were also assessed.Results: Higher adherence rates were observed in the intervention group (p<0.05). The use of others drugs did not influence adherence to ART (p=0.30). There was a positive correlation between adherence and the percentage of patients in the intervention group with undetectable viral loads (p=0.0004) and higher levels of CD4 lymphocytes (p=0.0024).Conclusion: The pharmaceutical care model developed by the SAME improved patient adherence to ART as well as clinical outcomes.

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“…l virus de la inmunodeficiencia humana (VIH), es uno de los principales problemas de salud pública y para el 2016 había aproximadamente 36,7 millones de personas infectadas 1 . La terapia anti-retroviral combinada (TARc) ha permitido un control en la progresión de la infección, ya que contribuye a la disminución de la morbi-mortalidad y al aumento de la esperanza de vida en los pacientes infectados 2, 3 .…”

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Relevancia clínica de las interacciones medicamentosas en pacientes infectados con el virus de la inmunodeficiencia humana: actualización 2015-2017

Pino-Marín

et al. 2019

Rev. chil. infectol.

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Evaluating the Impact of a Pharmacist-Led Antiretroviral Stewardship Program on Reducing Drug Interactions in HIV-Infected Patients

Abstract: An ARVSP is critical in the prevention of CSDDIs and errors to improve safety in HIV-infected patients.

Cited by 21 publications

References 9 publications

Polypharmacy and drug-related problems among people living with HIV/AIDS: a single center experience

Polypharmacy and drug-related problems among people living with HIV/AIDS: a single center experience

The Effectiveness of a Pharmaceutical Care Model on Adherence to Antiretroviral Therapy: A SAME-Based Cohort Study in Brazil

Relevancia clínica de las interacciones medicamentosas en pacientes infectados con el virus de la inmunodeficiencia humana: actualización 2015-2017

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