Evaluating the impact of the hexosamine biosynthesis pathway and O-GlcNAcylation on glucose metabolism in bovine granulosa cells

Maucieri, Abigail M; Townson, David H.

doi:10.1016/j.mce.2023.111863

Cited by 3 publications

(2 citation statements)

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“…A critical interaction occurs between the HBP and the highly active glycolytic pathway in cancer cells. Recent findings by Maucieri et al revealed that suppression of O-GlcNAcylation in Granulosa cells impaired the expression of hexokinase and pyruvate kinase [ 30 ]. Furthermore, HBP-mediated protein O-GlcNAcylation can influence the stability and function of glycolytic enzymes, thereby impacting their enzymatic activity.…”

Section: Introductionmentioning

confidence: 99%

“…The interplay between the HBP and other metabolic pathways, such as glycolysis and the pentose phosphate pathway (PPP), offers additional targets for potential interventions. Modulating key enzymes or regulators involved in metabolic cross-talk, such as phosphofructokinase, pyruvate kinase, and pyruvate dehydrogenase in aerobic glycolysis, could impact HBP activity, influencing lung cancer cell metabolism and survival [ 30 ]. This modulation may help restore metabolic homeostasis, inhibit tumor growth, and overcome drug resistance.…”

Section: Introductionmentioning

confidence: 99%

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Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer

Zou,

Liu,

Liu

et al. 2023

World J Surg Onc

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Lung cancer is a highly prevalent malignancy characterized by significant metabolic alterations. Understanding the metabolic rewiring in lung cancer is crucial for the development of effective therapeutic strategies. The hexosamine biosynthesis pathway (HBP) is a metabolic pathway that plays a vital role in cellular metabolism and has been implicated in various cancers, including lung cancer. Abnormal activation of HBP is involved in the proliferation, progression, metastasis, and drug resistance of tumor cells. In this review, we will discuss the function and regulation of metabolic enzymes related to HBP in lung cancer. Furthermore, the implications of targeting the HBP for lung cancer treatment are also discussed, along with the challenges and future directions in this field. This review provides a comprehensive understanding of the role and intervention of HBP in lung cancer. Future research focusing on the HBP in lung cancer is essential to uncover novel treatment strategies and improve patient outcomes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%