Evaluating the impacts of some environmentally relevant factors on the availability of bisphenol A with negligible-depletion SPME

Hu, Xialin; Peng, Jinfeng; Liu, Jingfu; Jiang, Guibin; Jönsson, Jan Åke

doi:10.1016/j.chemosphere.2006.07.028

Cited by 25 publications

(9 citation statements)

References 31 publications

(39 reference statements)

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“…There are procedural differences between the two studies that may explain some, but not all, of the discrepant findings. First, in the Doerge study, DMSO was used as a solvent and water as the vehicle for BPA delivery as opposed to EtOH as solvent and oil as vehicle in the present study and BPA release and absorption can differ with these variables [36, 37]. It is possible that relative to an oil depot, BPA is more rapidly released from water resulting in different absorption kinetics, particularly with the s.c. route which would explain the extreme peak after s.c. injection in the Doerge study.…”

Section: 4 Discussionmentioning

confidence: 99%

Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague–Dawley rats

Prins

Birch

et al. 2011

Reproductive Toxicology

134

103

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The present study examines BPA pharmacokinetics in neonatal rats following s.c. injection or oral delivery of 10μg BPA/kg BW and compares susceptibility to estrogen-induced prostate intraepithelial neoplasia (PIN) following either exposure route. Serum BPA in PND3 rats was measured using HPLC-MS-MS. Free and total BPA at Cmax were 1.77 and 2.0 ng/ml, respectively following injection and 0.26 and 1.02 ng/ml, respectively following oral exposure. The AUC0-2 for free and total BPA was 4.1-fold and 1.8-fold greater, respectively, in s.c. versus oral delivery. While exposure route affected BPA metabolism, internal dosimetry following s.c. injection of 10μg BPA/kg BW is similar to BPA levels observed in humans. Prostates from aged rats given s.c. or oral BPA neonatally and T+E implants as adults exhibited nearly identical, heightened susceptibility to PIN incidence and score as compared to neonatal oil-controls. These findings on prostate health are directly relevant to humans at current BPA exposure levels.

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Section: 4 Discussionmentioning

confidence: 99%

Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague–Dawley rats

Prins

Birch

et al. 2011

Reproductive Toxicology

134

103

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“…The effects of CNMs on the uptake of a compound might thus be better explained via the C free that can be measured with negligible depletion solid-phase microextraction (nd-SPME) (Mayer et al, 2000a,b;Hu et al, 2006;Yang et al, 2008). The C free of polycyclic aromatic hydrocarbons (PAHs) in nC 60 suspensions was measured in our previous study (Hu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of organochlorine compounds in aqueous suspensions of fullerene: Evaluated with medaka (Oryzias latipes) and negligible depletion solid-phase microextraction

Liu

Zhou

et al. 2010

Chemosphere

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a b s t r a c tThe wide application of engineered nanomaterials, such as fullerene (C 60 ), will inevitably lead to their release into the aqueous environment, which may alter the bioavailability of organic compounds to aquatic organisms. Negligible depletion solid-phase microextraction (nd-SPME) together with medaka (Oryzias latipes) bioaccumulation were used to study the effects of aqueous suspensions of fullerene (nC 60 ) on the bioavailability of eight organochlorine compounds (OCCs) (log K OW 3.76-6.96). Freely dissolved concentrations of OCCs decreased by 11.5-88.4% at addition of 5 mg L À1 nC 60 as indicated by reduced equilibrium concentrations in the SPME fiber coating, the highest reduction being observed for the most hydrophobic OCCs. Medaka bioaccumulation study demonstrated that at the kinetic uptake regime, nC 60 significantly decreased the bioaccumulation of the high hydrophobic OCCs (log K OW > 6), but slightly enhanced the bioaccumulation of the less hydrophobic OCCs (log K OW < 6). The OCC concentrations in medaka (C fish ) at the kinetic uptake regime linearly correlated with that in nd-SPME fiber (C fiber ) without nC 60 (p = 0.007-0.013, R 2 = 0.666-0.723), but this correlation deteriorated with the presence of nC 60 (p = 0.073-0.081, R 2 = 0.423-0.440). These results suggest that in nC 60 the uptake mechanism of OCCs to medaka is different from that to nd-SPME fiber. While only the freely dissolved OCCs are available to nd-SPME fiber, both the freely dissolved and the nC 60 associated OCCs contributed to the accumulation of OCCs to medaka.

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“…This slight enhancement of C free with DOC concentration, however, should not be neglected. This phenomenon also was observed for other polar compounds, such as dinitrophenolic compounds [32], bisphenol A [33], and alkylphenols [17]. Biological exposure experiments indicated that statistically, the bioavailability of ATR was not affected by the DOM [28,29], but enhanced uptake by Daphnia magna was observed in cases with low DOC concentrations [28].…”

Section: Resultsmentioning

confidence: 78%

Development of negligible depletion hollow fiber–protected liquid‐phase microextraction for sensing freely dissolved triazines

Liu

Jönsson

et al. 2009

Enviro Toxic and Chemistry

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Abstract-A new sampling method, termed negligible depletion hollow fiber-protected liquid-phase microextraction, was developed for sensing the freely dissolved concentration (C free ) and evaluating the availability of atrazine (ATR), desethyl atrazine (DEA), and simazine (SIM) in water. The sampling device was prepared by impregnating 1-octanol to both the pores and the lumen of a piece of polypropylene microporous hollow fiber membrane. After equilibrium and negligible depletion extraction, the 1-octanol in the lumen of the hollow fiber (10 l) was collected for determination of triazines. Determination of C free and the distribution coefficient to 1-octanol (D OW ) can be performed with this technique. A wide linear working range (1-200 g/L) and low detection limits (0.1-1 g/L) were obtained for triazines. Measured log D OW values of DEA (1.44 Ϯ 0.04), SIM (2.06 Ϯ 0.06), and ATR (2.33 Ϯ 0.05) agreed well with those reported in the literature. The measured D OW values were independent of the chemical concentration and sample pH (pH 3-10) and negligibly affected by the sample salinity (0-500 mM), suggesting that environmentally relevant pH and salinity have no significant effects on the availability of triazines. Although a slight (Յ31%) increase of C free was observed, one-way analysis of variance indicated the C free of triazines were not significantly affected by the presence of Aldrich humic acid, Acros humic acid, and bovine albumin V (dissolved organic carbon [DOC], 0-100 mg/L). From 3 to 36% of the spiked triazines, however, were found to associate with the dissolved organic matter (DOM) in surface-water samples (DOC, 32.0-61.9 mg/L), suggesting the origin of the DOM is a key parameter in determining its association with and, thus, the availability of triazines.

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Evaluating the impacts of some environmentally relevant factors on the availability of bisphenol A with negligible-depletion SPME

Cited by 25 publications

References 31 publications

Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague–Dawley rats

Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague–Dawley rats

Bioavailability of organochlorine compounds in aqueous suspensions of fullerene: Evaluated with medaka (Oryzias latipes) and negligible depletion solid-phase microextraction

Development of negligible depletion hollow fiber–protected liquid‐phase microextraction for sensing freely dissolved triazines

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